Composition for improving side effects of oral bowel cleansing or intestinal tract preparation agent electrolyte disorders

Abstract

The present invention relates to a composition for improving the side effects of oral gut purging or intestinal preparation agent electrolyte disorders. Specifically, the invention provides a composition which comprises arabinose, sodium sulfate, sodium chloride, potassium chloride and sodium bicarbonate. The invention finds that oral administration of arabinose, sodium sulfate, sodium chloride, potassium chloride and sodium bicarbonate can effectively improve the side effects of electrolyte disorder, intestinal mucosa permeability increase, intestinal mucosa injury, intestinal mucosa barrierdamage and the like caused in the intestinal tract preparation process of the bowel cleansing agent or the intestinal tract preparation agent; therefore, side effects caused by oral administration ofthe gut purge or the intestinal tract preparation are improved, and health recovery of intestinal tract preparation of a patient is improved.

Description

technical field [0001] The invention relates to the field of medicaments, in particular to a composition for improving the side effects of oral bowel cleansing or intestinal preparation preparation electrolyte disturbance. Background technique [0002] Electrolytes are widely distributed inside and outside cells, participate in various important metabolic activities in the body, and play a very important role in maintaining normal life activities. Disturbance of electrolyte metabolism can cause corresponding obstacles to the physiological functions of various organ systems, especially the cardiovascular system and nervous system, and the substance metabolism of the body. In severe cases, it can lead to animal death. Potassium ions in serum electrolytes can maintain the normal physiological activities of the body, ensure cell metabolism, especially the electrical activity of cardiomyocytes, normal functions of nerves and muscles, maintain normal acid-base balance, and stabili...

AI Technical Summary

Problems solved by technology

However, magnesium sulfate often causes rapid loss of electrolytes in the digestive juice during intestinal preparation, and at the same time reduces the effective absorption of supplemented electrolytes, resulting in electrolyte disturbances such as hyponatremia and hypokalemia, which are harmful to patients with intestinal preparation health hazard

And studies have also shown that intestinal cleansing agents such as magnesium sulfate often lead to increased intestinal mucosal permeability, intestinal mucosal damage, and intestinal mucosal barrier damage during intestinal preparation.

Therefore, the electrolyte disturbance, intestinal mucosal permeability increase, intestinal mucosal damage and intestinal mucosal barrier damage caused by bowel cleansing agents seriously affect the patient's psychology of bowel preparation before colonoscopy and greatly reduce the patient's compliance. , and adversely affect the recovery of the patient's health

Images