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Phenylephrine hydrochloride and chlorphenamine maleate preparation and preparation method thereof

A technology of renin and preparations, which is applied in the field of renin phenamine preparations and its preparation, can solve the problems of impurities generated by addition reactions, etc., and achieve the effects of fast release speed, high stability, and rapid control of cold symptoms

Inactive Publication Date: 2021-03-12
BRIGHT FUTURE PHARMA LAB LTD (CN)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The object of the present invention is to provide a kind of renin that amine preparation and preparation method thereof, aim at solving existing compound preparation, phenylephrine and chlorpheniramine maleate or brompheniramine maleate add The technical problem of the impurity generated by the reaction

Method used

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  • Phenylephrine hydrochloride and chlorphenamine maleate preparation and preparation method thereof
  • Phenylephrine hydrochloride and chlorphenamine maleate preparation and preparation method thereof
  • Phenylephrine hydrochloride and chlorphenamine maleate preparation and preparation method thereof

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preparation example Construction

[0047] The embodiment of the present invention provides a preparation method of renin iramine preparation, which comprises the following steps:

[0048] S1. Provide a first core, a first coating material, a second core and a second coating material, the first core is phenylephrine or a pharmaceutically acceptable salt thereof and the first pharmaceutically active agent and / or Or the mixture of the first auxiliary material, the second core is a mixture of chlorpheniramine maleate and / or brompheniramine maleate and the second pharmaceutically active agent and / or the second auxiliary material;

[0049] S2. Coating the first core with the first coating material to obtain the first coating;

[0050] S3. Coating the second core with the second coating material to obtain the second coating;

[0051] S4. Mixing the first coating and the second coating to obtain a reniniramine preparation.

[0052] In the preparation method provided by the embodiment of the present invention, the fir...

Embodiment 1

[0065] This embodiment provides a kind of renin iramine preparation (capsule) and preparation method thereof, and the steps are as follows:

[0066] (11) Phenylephrine hydrochloride coating:

[0067] (111) Material pretreatment: 0.5kg phenylephrine hydrochloride, 14kg acetaminophen, 1.5kg caffeine, 0.4kg bromhexine hydrochloride, 1.4kg pregelatinized starch, 0.5kg povidone, 0.7kg corn Starch, 0.25kg crospovidone, and 0.5kg microcrystalline cellulose are respectively passed through a 40-60 mesh sieve;

[0068] (112) Fluidized mixing: when the air inlet temperature is 50-60°C, the air inlet volume is 100-300m 3 Under the condition of / h, the sieved material is sucked into the fluidized bed, and fluidized and mixed for 5 minutes to obtain the material in a fluidized state;

[0069] (113) Spray granulation: when the air inlet temperature is 50-60°C, the atomization pressure is 1.0-3.0bar, and the air inlet volume is 100-300m 3 / h, spray speed is under the condition of 0.1-0.3kg...

Embodiment 2

[0091] This embodiment provides a kind of renin iramine preparation (capsule) and preparation method thereof, and the steps are as follows:

[0092] (21) Phenylephrine hydrochloride coating:

[0093] (211) Material pretreatment: 0.5kg phenylephrine hydrochloride, 12.5kg acetaminophen, 1.5kg caffeine, 0.4kg bromhexine hydrochloride, 1.25kg pregelatinized starch, 0.7kg povidone, 0.7kg Corn starch, 0.25kg croscarmellose sodium, and 0.5kg microcrystalline cellulose are respectively passed through a 40-60 mesh sieve;

[0094] (212) Fluidized mixing: when the air inlet temperature is 50-60°C, the air inlet volume is 100-300m 3 Under the condition of / h, the sieved material is sucked into the fluidized bed, and fluidized and mixed for 5 minutes to obtain the material in a fluidized state;

[0095] (213) Spray granulation: when the air inlet temperature is 50-60°C, the atomization pressure is 1.0-3.0bar, and the air inlet volume is 100-300m 3 / h, spray speed is under the condition ...

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Abstract

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a phenylephrine hydrochloride and chlorphenamine maleate preparation and a preparation method thereof. The phenylephrine hydrochloride and chlorphenamine maleate preparation comprises a mixture formed by a first coating and a second coating, wherein the first coating is composed of a first coreand a first coating film coating the surface of the first core, the second coating is composed of a second core and a second coating film coating the surface of the second core, the first core is a mixture of phenylephrine or a pharmaceutically acceptable salt thereof and a first pharmaceutical active agent and / or a first auxiliary material, and the second core is a mixture of chlorpheniramine maleate and / or bromopheniramine maleate and a second pharmaceutical active agent and / or a second auxiliary material. According to the phenylephrine hydrochloride and chlorphenamine maleate preparation,the first core and the second core are not in contact with each other, so that the phenylephrine is thoroughly isolated from chlorpheniramine maleate and / or bromopheniramine maleate, and the obtainedphenylephrine hydrochloride and chlorphenamine maleate preparation has higher product stability, safety and effectiveness.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a renin pheniramine preparation and a preparation method thereof. Background technique [0002] Flu is a common disease, and clinically at present the treatment of flu is still based on symptomatic treatment. Since a variety of symptoms are produced when a cold occurs, the use of compound preparations can target multiple cold symptoms at the same time, which has the advantage of comprehensive control. The ingredients of common anti-cold medicines mainly include chlorpheniramine maleate / brompheniramine maleate and phenylephrine. Chlorpheniramine maleate and brompheniramine maleate are antihistamines that can relieve symptoms such as runny nose, nasal congestion, and sneezing. Phenylephrine is a potent α-receptor agonist that selectively constricts blood vessels, relieves congestion and swelling of the nasopharyngeal mucosa, and relieves symptoms s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/36A61K9/50A61K47/38A61K47/32A61K45/06A61K31/4402A61K31/137A61P11/00
CPCA61K9/2866A61K9/284A61K9/5084A61K9/5042A61K9/5026A61K45/06A61K31/4402A61K31/137A61P11/00
Inventor 邓家华曾学俊吴涛
Owner BRIGHT FUTURE PHARMA LAB LTD (CN)
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