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Novel application of Lijiashou tablets in prevention and treatment of senile dementia

A technology for senile dementia and traditional Chinese medicine, which is applied in the directions of medical preparations containing active ingredients, plant raw materials, and pill delivery, and can solve problems such as unsatisfactory treatment effects.

Inactive Publication Date: 2021-03-05
GUANGZHOU BAIYUSN GUANGHUA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, cholinesterase inhibitors have serious side effects such as liver toxicity, gastrointestinal reactions and bronchospasm, etc. At the same time, long-term use of antipsychotic drugs may cause mental dependence, and these drugs cannot reverse neurological and organic symptoms. Sexual damage, resulting in unsatisfactory treatment effect, so the prevention and treatment of senile dementia is particularly important

Method used

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  • Novel application of Lijiashou tablets in prevention and treatment of senile dementia
  • Novel application of Lijiashou tablets in prevention and treatment of senile dementia
  • Novel application of Lijiashou tablets in prevention and treatment of senile dementia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1: Long-term toxicity test of Lijiashou Tablets on rats

[0029] 1. Experimental materials

[0030] 1.1 Experimental animals

[0031] 120 SD rats, male and female, SPF grade, body weight 230-250g, provided by Guangdong Medical Experimental Animal Center, SYXK (Guangdong) 2018-0002). The rats were raised under the conditions of the second-level experimental animal laboratory, the indoor temperature was 19-22° C., and the relative humidity was 40%-50%. There were 5 animals in each cage, and they were given pellet feed, free to eat and drink. Start the experiment one week after the experimental animals adapt to the new environment, and take appropriate measures to reduce the damage to the animals during the experiment.

[0032] 1.2 Experimental drugs

[0033] Test drug: Lijiashou Tablets (Guangzhou Baiyunshan Guanghua Pharmaceutical Co., Ltd.; Z44020199; specification: 0.34g; dosage: 3 tablets at a time, 2 times a day.)

[0034] Preparation of medicinal solu...

Embodiment 2

[0070] Example 2: Effect of Lijiashou Tablets on Learning and Memory Impairment in Aβ1-42-Induced Dementia Model Rats

[0071] The present invention uses the SD rat model of senile dementia to conduct experiments, and finds that Lijiashou Tablets can significantly reduce the level of free radicals in the body and reduce the cytotoxicity of free radical accumulation, that is, discover the use of Lijiashou Tablets to improve oxidative stress damage.

[0072] The use of Lijiashou Tablets in improving oxidative stress damage is further illustrated by the following specific examples:

[0073] 1. Experimental materials

[0074] 1.1 Experimental animals

[0075] 120 SD rats, half male and half male, SPF grade, weighing 220-240 g, provided by Guangdong Medical Experimental Animal Center, SYXK (Guangdong) 2018-0002). The rats were raised under the conditions of the second-level experimental animal laboratory, the indoor temperature was 19-22° C., and the relative humidity was 40%-50%...

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Abstract

The invention relates to novel application of Lijiashou tablets in prevention and treatment of senile dementia. The Lijiashou tablets can reduce the level of free radicals in the body, reduce cytotoxicity of free radical accumulation and improve oxidative stress injury, thereby improving senile dementia behaviors caused by amyloid peptide A beta accumulation. The Lijiashou tablets can also obviously restore the AChE and ChAT contents in the hippocampus of the body and relieve cholinergic system injury. The Lijiashou tablets do not have toxic or harmful effects on the body after being taken fora long time, and can achieve the goal of preventing and treating senile dementia after being taken for a long time.

Description

technical field [0001] The invention relates to a new application of Lijiashou tablets, a traditional Chinese medicine composition, in the prevention and treatment of senile dementia, belonging to the field of Chinese patent medicines. Background technique [0002] Alzheimer's disease usually refers specifically to Alzheimer's disease, which is a neurodegenerative disease with insidious onset and progressive development. Patients may have clinical manifestations such as memory impairment, aphasia, apraxia, agnosia, impairment of visuospatial ability, impairment of abstract thinking and calculation, and changes in personality and behavior. The degree of deterioration of the patient is severe, the course of the disease is not stable, and the patient may have different degrees of mental retardation, which seriously endangers the health of the patient. [0003] At present, the pathogenesis of Alzheimer's disease includes gene mutation, excessive aggregation of amyloid Aβ, hyper...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61K36/65A61K9/20A61P25/28A61K31/355
CPCA61K9/20A61K31/355A61K36/074A61K36/254A61K36/258A61K36/296A61K36/481A61K36/65A61K36/71A61P25/28A61K2300/00
Inventor 马蓉刘宏李玉辉郑如文江志强张俊华杜海泳
Owner GUANGZHOU BAIYUSN GUANGHUA PHARMA
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