Ring fiber core beak-shaped optical fiber optical tweezer system with stable capturing function

Abstract

A ring fiber core bird beak-shaped optical fiber optical tweezer system with a stable capturing function is characterized in that optical fiber optical tweezers are composed of a ring fiber core birdbeak-shaped optical fiber probe, a laser device, an adjusting frame, a sample groove, a microscopic imaging system, a Raman laser source and a Raman detector. The bird beak-shaped optical fiber probeis characterized in that evanescent field distribution of the side face of an optical fiber is enhanced by changing the curvature radius of a bent tip area of the optical fiber, gradient force borne by cells is increased, and therefore stable capture of the cells is achieved. Finally, Raman laser is emitted into the bird beak-shaped optical fiber optical tweezers, and corresponding Raman frequencyshift can be acquired through a detector, thereby realizing cell characteristic detection.

Description

[0001] (1) Technical field [0002] The invention relates to a ring fiber core bird's beak optical fiber optical tweezers system with a stable capturing function, which belongs to the technical field of light manipulation. [0003] (2) Background technology [0004] Since the pioneering work of Ashkin et al., optical tweezers have become one of the most important research tools in the field of biological and physical research. Tapered fiber optic tweezers (TOFTs) are an important optical manipulation tool, widely used in the trapping of micro-nano particles and the manipulation of multi-particles, such as the organization of micro-particles and the patterning of cells. In typical TOFTs, fabrication methods such as polishing, thermal drawing, and chemical etching are used to process the fiber tip into a tapered structure. In recent years, a lot of research has been done on the performance of tapered fiber optic tweezers to achieve non-contact trapping, dual particle trapping, a...

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Problems solved by technology

[0007] However, the process difficulty and work efficiency of the above-mentioned optical fiber optical tweezers preparation process cannot meet the requirements at the same time, such as a single optical fiber optical tweezers based on wavelength division multiplexing technology (patent number: CN109254346B) and a single optical fiber based on elliptical core optical fiber Optical tweezers (patent number: CN104698532A), the manufacturing process of the optical fiber optical tweezers in the invention is simple, but it can only achieve cell capture and position adjustment in the axial direction or in front of the fiber tip, and its application range is limited

And a single optical fiber optical tweezers (patent No.: CN103996423A) with a laterally adjustable capture position and a fiber optical tweezers probe with a secondary cone angle prepared by a two-step method (patent No.: CN109212667A) use chemical corrosion to form an optical fiber probe. Needle, the concentration ratio is difficult to control, making it difficult to control the degree of the cone angle, and errors are likely to occur

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