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Nanoparticles comprising aromatic plant active ingredient

A technology of aromatic plants and active ingredients, applied in the direction of nanotechnology, nanotechnology, nanotechnology for materials and surface science, etc., can solve the problems of low encapsulation rate, incomplete encapsulation, strong and pungent smell, etc., and achieve Effects of improving sleep quality and improving depressive symptoms

Inactive Publication Date: 2021-02-26
北京银谷芳香科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned nano-encapsulation technology generally needs to use lecithin, chitosan, cyclodextrin, etc. as nano-carrier materials for forming nanoparticles, so there will be problems such as incomplete encapsulation and low encapsulation efficiency, which cannot be fully achieved. Application requirements of plant essential oils in certain fields
[0004] Therefore, there is a need for a method for preparing nanoparticles containing aromatic plant active ingredients, which can not only solve the problems of extremely unstable, highly volatile, strong and pungent smell of plant active ingredients with aromatic odors at room temperature, but also solve the problem of In the prior art, there are problems such as incomplete encapsulation and low encapsulation rate in nano-encapsulation technology, which can expand the application scope of this plant active ingredient in food, cosmetics, health and other fields

Method used

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  • Nanoparticles comprising aromatic plant active ingredient
  • Nanoparticles comprising aromatic plant active ingredient
  • Nanoparticles comprising aromatic plant active ingredient

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0095] Embodiment 1: the preparation of the nanosuspension of rose essential oil

[0096] First, weigh 40 mg of Poloxamer 407 (purchased from Shanghai Yien Chemical Technology Co., Ltd.) as a steric stabilizer and 80 mg of Tween 80 (purchased from Shanghai Yien Chemical Technology Co., Ltd.) as a charge stabilizer at room temperature. The two are placed in 10mL of distilled water, stirred at 500rpm for 3 hours, the stabilizer is completely swollen, and the water phase is prepared; secondly, accurately weigh 40mg of rose essential oil (made by a method well known to those skilled in the art) and dissolve in In absolute ethanol, it was dissolved completely by ultrasonic to prepare the organic phase; then, under the stirring condition of 500rpm, the organic phase was slowly added dropwise at the speed of 0.1mL for 10 seconds, and then stirred and reacted at 500rpm for 3 hours to make it The reaction is complete, and the residual organic solvent is removed; the opalescent suspensi...

Embodiment 2

[0101] Example 2: Preparation of solid nanoparticles of rose essential oil and its reconstitution

[0102] On the basis of the nanosuspension of rose essential oil prepared according to the preparation method described in Example 1, 5% sucrose was added under clean conditions as a freeze-drying protection agent, after mixing evenly, it was placed in a vial, and the Freeze-dry at -60°C to finally obtain solid nanoparticles (lyophilized powder) of rose essential oil.

[0103] The solid nanoparticle (freeze-dried powder) of the rose essential oil obtained is redissolved in the same volume of distilled water used in Example 1 to obtain the nanocrystal suspension of the rose essential oil after reconstitution, and utilize the Malvern nano particle size analyzer again and Zeta potential meter to measure the particle size properties of the nanocrystal suspension of rose essential oil, see appendix image 3 and Table 1 above. It can be seen that, in the nanocrystal suspension of ros...

Embodiment 3

[0105] Embodiment 3: the preparation of the nanosuspension of rose essential oil

[0106] First, weigh 80 mg of poloxamer 188 (purchased from Shanghai Yien Chemical Technology Co., Ltd.) as a steric stabilizer and 200 mg of sodium dodecylsulfonate as a charge stabilizer at room temperature, and place the two in 10mL of distilled water was stirred at 700rpm for 3 hours to completely swell the stabilizer to prepare an aqueous phase; secondly, accurately weigh 40mg of rose essential oil and dissolve it in absolute ethanol, and dissolve it completely by ultrasonic to prepare an organic phase; then , under the condition of stirring at 700rpm, add the organic phase dropwise at a speed of 1mL in 2 seconds, and then stir the reaction at 700rpm for 2 hours to make it react completely and remove the residual organic solvent; the formed opalescent The suspension was continued to be ultrasonicated for 30 minutes under ultrasonic conditions to fully stabilize the system to obtain a nanosus...

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Abstract

The invention provides a method for directly preparing aromatic plant active ingredients into solid nano particles without a nano carrier material, and the nano particles prepared by the method. According to the method disclosed by the invention, a nano-carrier material is not needed, so that the active ingredients of the aromatic plants are not restricted by the encapsulation efficiency any more,and finally, the application limitation of the active ingredients of the liquid aromatic plants in a special scene is solved, and the application range of the aromatic plant active ingredients in food, cosmetics, depression symptom improvement, sleep quality improvement and other large health fields is effectively expanded.

Description

technical field [0001] The invention relates to the field of nanotechnology of aromatic plants, in particular, the invention relates to a method for preparing nanoparticles containing active ingredients of aromatic plants and the nanoparticle containing active ingredients of aromatic plants prepared therefrom. Background technique [0002] Aromatic plants have been widely developed and applied in traditional food, medicine, daily necessities, and human health care. The active ingredients of aromatic plants are generally applied in the form of their plant extracts, for example in the form of plant essential oils known as "liquid gold". Take rose essential oil as an example. It is extracted from rose flowers. It is known as the "king of essential oils" of flowers. It has the functions of removing organ hardening and repairing cells, and is not only widely used in cosmetic fields such as beauty, skin care, and hair care, but also in the fields of medicine and food. However, m...

Claims

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Application Information

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IPC IPC(8): C11B9/00B01F13/10B01F3/22B82Y30/00B82Y40/00B01F23/80
CPCC11B9/00B82Y30/00B82Y40/00B01F23/804B01F23/809B01F33/80
Inventor 霍铭朱月星熊江辉
Owner 北京银谷芳香科技有限公司
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