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Drug-loaded nano-robot and preparation method and application thereof

A nano-robot and drug-loaded nano technology, applied in the field of robotics, can solve problems such as cumbersome processes and complex systems, and achieve the effects of efficient treatment, high loading rate, and reduced drug loss

Active Publication Date: 2021-02-23
SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The most representative class is exactly the disulfide bond compound, and the method of introducing disulfide bond usually includes 1) converting amino group, carboxyl group, etc. into sulfhydryl group, and regenerating disulfide bond; The cross-linking of the system introduces disulfide bonds. These methods are complex and inevitably introduce impurities, and the process is cumbersome

Method used

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  • Drug-loaded nano-robot and preparation method and application thereof
  • Drug-loaded nano-robot and preparation method and application thereof
  • Drug-loaded nano-robot and preparation method and application thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0064] In a specific embodiment, an L-shaped robot is used as an example to carry out drug loading, wherein the preparation method of the L-shaped robot includes the following steps:

[0065] (1) Evaporate a 150nm metal aluminum layer on a one-inch silicon wafer by electron beam evaporation.

[0066] (2) On the silicon wafer with a 150nm thick metal aluminum layer on the obtained surface, the electron beam glue of the AR-7520.07 spin coating model is spin coated (the spin coating speed is 3000r / min) for 60s, and the obtained silicon The slices were placed on a hot plate at 90°C and baked for 2 min.

[0067] (3) Put the prepared silicon wafer sample into the electron beam exposure machine, and select the exposure parameter 600uC / cm 2 .

[0068] (4) Take out the written silicon wafer sample from the electron beam exposure machine, put it into a glass vessel filled with electron beam developer, shake the glass vessel for 1min to 2min, take out the sample, put it on a hot plate,...

Embodiment 1

[0080] This embodiment provides a drug-loaded nanorobot, including:

[0081] nanorobots;

[0082] A polymer brush, comprising a hydrophilic end and a hydrophobic end, the hydrophobic end of the polymer brush is grafted on the surface of the nanorobot;

[0083] a drug attached to the hydrophilic end of the polymer brush;

[0084] Among them, the robot is the L-shaped robot prepared above, and the average particle size of the L-shaped robot is 800nm; the drug is doxorubicin; the polymer brush is SS-PAA, and the structural formula is as follows:

[0085]

[0086] Wherein, m:n=3:7, m=1-50.

[0087] This embodiment also provides a method for preparing a drug-carrying robot, figure 1 It is a schematic diagram of the preparation of the drug-loading robot, and the preparation method includes:

[0088] (1) Doxorubicin (10mg) was sonicated in 5% (w / v) PVA aqueous solution (2mL), L-shaped robot (3mg) and SS-PAA (25mg) were dissolved in dichloromethane solution (10mL ), the two so...

Embodiment 2

[0096] This embodiment provides a drug-loaded nanorobot, including:

[0097] nanorobots;

[0098] A polymer brush, comprising a hydrophilic end and a hydrophobic end, the hydrophobic end of the polymer brush is grafted on the surface of the nanorobot;

[0099]a drug attached to the hydrophilic end of the polymer brush;

[0100] Wherein, the robot is the L-shaped robot prepared above, and the average particle size of the L-shaped robot is 1000nm; the drug is doxorubicin; the polymer brush is SS-PAA, and the structural formula is as follows:

[0101]

[0102] Wherein, m:n=2:8, m=1-50.

[0103] This embodiment also provides a preparation method of a drug-loaded robot, the preparation method comprising:

[0104] (1) Doxorubicin (5 mg) was ultrasonically dissolved in 3% (w / v) PVA aqueous solution (2 mL), L-shaped robot (1.5 mg) and SS-PAA (20 mg) were dissolved in dichloromethane solution ( 10 mL), the two solutions were mixed and ultrasonicated for 20 min to form an O / W oil...

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Abstract

The invention provides a drug-loaded nano-robot and a preparation method and application thereof. The drug-loaded nano-robot comprises a nano-robot, a polymer brush and a drug, wherein the polymer brush comprises a hydrophilic end and a hydrophobic end, the hydrophobic end of the polymer brush is grafted to the surface of the nano-robot, and the drug is connected with the hydrophilic end of the polymer brush. According to the drug-loaded robot, the drug is loaded onto the nano-robot through the polymer brush with relatively good biocompatibility, the efficient treatment of the nano-robot on tumors is realized, and the potential medical application of the nano-robot is expanded. The drug-loaded nano-robot can effectively target a tumor and directly reach the deep part of the tumor, so thatthe drug-loaded nano-robot can more accurately and effectively target a focus point, and functions of biodegradation and redox response drug release are achieved. In the preparation process, the drug-loaded nano-robot can be obtained by a simple method, the drug loss can be reduced, a high loading rate can be achieved, and therefore the drug-loaded nano-robot has wide biological application prospects.

Description

technical field [0001] The invention belongs to the field of robots, and relates to a drug-loaded nano-robot and its preparation method and application, in particular to a nano-robot with redox-responsive drug release and its preparation method and application. Background technique [0002] Nano-robots are widely used due to their small size, sensitive movement and powerful functions, especially in biomedicine. At present, although drug-loaded nanoparticles have some clinical effects, there are still many defects in traditional clinical surgery, radiotherapy and chemotherapy, such as easy recurrence, lack of targeting, multidrug resistance and severe side effects that limit its further development. . Because nanoparticles cannot effectively target tumors only by circulation and penetration in the body, and cannot directly reach the depth of tumors. As an emerging interdisciplinary field, nanomedical robots play an important role in targeted drug delivery. Magnetic nanorobo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61K47/34A61P35/00
CPCA61K31/704A61K47/34A61P35/00
Inventor 郑裕基宋小霞江腾郭思琪
Owner SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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