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Preparation method of phenylacetic acid

A production method and technology of phenylacetic acid, applied in the preparation of carboxylate salts, chemical instruments and methods, and the preparation of organic compounds, etc., can solve the problem of low atom utilization in synthesis methods, increased reaction pressure conditions, equipment, and increased demand for high-pressure resistance, etc. problems, achieve good recycling performance, solvent recyclability, and reduce usage

Pending Publication Date: 2021-02-19
NINGBO FREE TRADE ZONE HUAMENG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the existing synthetic methods for the synthesis of phenylacetic acid with industrial value, either highly toxic raw materials are selected to cause doubts about possible residues of highly toxic chemicals, or extremely high reaction pressure conditions are selected to increase the demand for high-pressure resistance of equipment and at the same time increase Unsafe factors in the production process, or low utilization of atoms in the selected synthetic method, so developing a new green and safe synthetic method for the production of phenylacetic acid is an important research direction for pharmaceutical intermediates and pesticide intermediates

Method used

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  • Preparation method of phenylacetic acid
  • Preparation method of phenylacetic acid
  • Preparation method of phenylacetic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A kind of preparation of catalyst for the production process of phenylacetic acid, comprising:

[0034] S1: Weigh the monomer N-vinylimidazole and L-α-phosphatidylcholine-β-arachidonoyl-γ-stearoyl (the mass ratio of the two is 1: 2.47) and dissolve it in DMF (with the monomer The liquid-solid ratio of N-vinylimidazole is 44.1mL: 1g), add AIBN (the mass ratio of monomer N-vinylimidazole is 0.12:1), stir mechanically at room temperature for 3h, and transfer the mixture to 50mL of high-pressure In a reaction kettle, conduct a hydrothermal reaction at 100°C for 24 hours; vacuum-dry at 40°C until the solvent is completely evaporated, and grind the obtained solid into powder to obtain the product M;

[0035] S2: Dissolve the product M in ethanol (the solid-to-liquid ratio is 1g: 25ml), and add n-bromoheptane (the product M and its solid-to-liquid ratio is 1g: 2.5mL) in the dark, and centrifuge after 12h under magnetic stirring Wash with a large amount of ethanol to remove ex...

Embodiment 2

[0041] A kind of phenylacetic acid production process is identical with embodiment 1 with the preparation of catalyst.

[0042] The difference between the production of phenylacetic acid and Example 1 is that in the Friedel-Crafts alkylation reaction, the mass ratio of benzene, product A, and catalyst is 1:3.86:0.43.

Embodiment 3

[0044] A kind of phenylacetic acid production process is identical with embodiment 1 with the preparation of catalyst.

[0045]The difference between the production of phenylacetic acid and Example 1 is that in the Friedel-Crafts alkylation reaction, the mass ratio of benzene, product A, and catalyst is 1:3.8:0.3.

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Abstract

The invention discloses a preparation method of phenylacetic acid, and relates to the technical field of organic synthesis. The preparation method of phenylacetic acid specifically comprises the following steps of: carrying out sulfonation reaction on alcohol, namely carrying out sulfonation treatment on 2-butyne-1, 4-diol by using p-toluenesulfonyl chloride to obtain a product A; carrying out Friedel-Crafts alkylation reaction, namely reacting benzene with the product A under the catalytic action of a polymerization ionic liquid catalyst to obtain a product B; and oxidizing alkyne, namely, bytaking tetrabutylammonium bromide as PCT and m-CPBA as an oxidizing agent, treating the product B to obtain phenylacetic acid. According to the preparation method of phenylacetic acid provided by theinvention, the prepared phenylacetic acid is high in yield, the operation is simple, the reaction conditions are easy to operate, and the safety is high.

Description

technical field [0001] The invention belongs to the technical field of organic synthesis, and in particular relates to a preparation method of phenylacetic acid. Background technique [0002] Phenylacetic acid is an important organic chemical raw material. It is mainly used in the production of penicillin, dimethazole and other drugs in the pharmaceutical industry; phenylacetic acid is chlorinated and esterified to obtain ethyl chlorophenylacetate, which is used for broad-spectrum organophosphorus The production of insecticides Daofengsan and Ethyl Daofengsan itself is also a pesticide plant growth stimulant; phenylacetic acid has a sweet honey taste at low concentrations, and phenylacetic acid and its esters are widely used as fixatives or modifiers. For the fragrance industry. [0003] The production process of phenylacetic acid mainly includes the acid hydrolysis method of benzyl nitrile, the alkaline hydrolysis method of benzyl nitrile, the styrene method, the carbonyla...

Claims

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Application Information

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IPC IPC(8): C07C51/285C07C57/32B01J31/06C07C1/32C07C15/46C08F230/02C08F226/06
CPCC07C51/285B01J31/06C07C1/322C08F230/02B01J2231/4205C07C2531/06C07C57/32C07C15/46C08F226/06
Inventor 陶虹
Owner NINGBO FREE TRADE ZONE HUAMENG BIOTECH
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