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Biebersteinia heterostemon Maxim extract and application thereof in preparation of anticonvulsants

A technology of anticonvulsants and smoked cows, which is applied in the field of medicine, can solve problems such as being in the blank, and achieve the effects of reducing equipment investment and energy consumption, reducing the number of convulsions/convulsion rate, and having a wide range of applications

Active Publication Date: 2021-02-09
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few reports on the pharmacodynamic substance basis of smoked cattle, especially the research on active ingredients for anticonvulsants is basically blank
[0005] At present, there is no report on the use of Geraniaceae (Geraniaceae) to fumigate Bovine (Biebersteinia) plants or their extracts to prepare highly active anticonvulsants

Method used

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  • Biebersteinia heterostemon Maxim extract and application thereof in preparation of anticonvulsants
  • Biebersteinia heterostemon Maxim extract and application thereof in preparation of anticonvulsants
  • Biebersteinia heterostemon Maxim extract and application thereof in preparation of anticonvulsants

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] The preparation of embodiment 1 Tibetan medicine smoked cattle extract

[0041] ⑴ After manual selection, cleaning, and impurity removal of the whole herb of smoked beef, it is dried in the shade indoors, crushed and passed through a 40-mesh sieve to obtain smoked beef medicinal powder;

[0042] (2) Heat and extract the above-mentioned smoked bovine medicinal material powder and ethanol with a volume fraction of 95% in a water bath at a temperature of 20°C at a solid-liquid ratio of 1:5 (g / mL), and obtain an extract after 48 hours;

[0043] (3) After the extract is ground 10 times by a colloid mill, it is homogenized under a pressure of 1Mpa, and the supernatant is obtained after centrifugation;

[0044] (4) Separating and removing impurities from the supernatant through a ceramic membrane with a pore size of 10 μm at a flow rate of 0.1 t / h at a temperature of 75° C. and a pressure of 3 MPa to obtain a filtrate, which is concentrated under reduced pressure and then smoked...

Embodiment 2

[0047] The preparation of embodiment 2 Tibetan medicine smoked cattle extract

[0048] ⑴ After manual selection, cleaning, and impurity removal of the whole herb of smoked beef, it is dried in the shade indoors, crushed and passed through a 300-mesh sieve to obtain smoked beef medicinal powder;

[0049] (2) Heat and extract the above-mentioned smoked bovine medicinal material powder and ethanol with a volume fraction of 10% in a water bath at a temperature of 80°C at a solid-liquid ratio of 1:80 (g / mL), and obtain an extract after 0.5 h;

[0050] (3) After the extract is ground once by a colloid mill, it is homogenized under a pressure of 200Mpa, and the supernatant is obtained after centrifugation;

[0051] (4) The supernatant is separated and removed by a ceramic membrane with a pore size of 0.01 μm at a flow rate of 10 t / h at a temperature of 15° C. and a pressure of 0.005 Mpa to obtain a filtrate, which is concentrated under reduced pressure to obtain smoked beef Extract ...

Embodiment 3

[0054] The preparation of embodiment 3 Tibetan medicine smoked cattle extract

[0055] ⑴ After the whole herb of smoked beef is manually selected, cleaned and removed, it is dried in the shade indoors, crushed and passed through a 60-mesh sieve to obtain smoked beef medicinal powder;

[0056] (2) Heat and extract the above-mentioned smoked bovine medicinal material powder and ethanol with a volume fraction of 90% in a water bath at a temperature of 60°C at a solid-liquid ratio of 1:30 (g / mL), and obtain an extract after 4 hours;

[0057] (3) After the extract is ground 3 times by a colloid mill, it is homogenized under a pressure of 50Mpa, and the supernatant is obtained after centrifugation;

[0058] (4) The supernatant is separated and removed through a ceramic membrane with a pore size of 0.2 μm at a flow rate of 1 t / h at a temperature of 55° C. and a pressure of 1 Mpa to obtain a filtrate, which is then concentrated under reduced pressure to obtain a smoked cow dip paste ...

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Abstract

The invention discloses a Biebersteinia heterostemon Maxim extract and an application thereof in preparation of anticonvulsants. The Biebersteinia heterostemon Maxim extract can obviously reduce the convulsion number / convulsion rate of mice, remarkably shorten the convulsion duration of the mice and remarkably prolong the convulsion incubation period, has a good anticonvulsion effect, and can prevent / treat symptoms such as febrile convulsion, convulsion and spasm. The provided Biebersteinia heterostemon Maxim extract has a broad application prospect in preparation of safe and high-activity anticonvulsants.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a smoked bovine extract and its application in the preparation of anticonvulsants. Background technique [0002] Convulsion is a symptom caused by brain dysfunction, manifested as muscle twitching with loss of consciousness, mostly caused by high fever, and most of the seizures are accompanied by paroxysmal abnormal high-frequency discharges caused by excessive excitability of neurons in local brain lesions , and spread to the surrounding, and then a syndrome of transient brain dysfunction. Convulsion is a common emergency in pediatrics and the most common neurological symptom in children. It is a common acute and severe disease in childhood. It is mainly characterized by rhythmic movements of limbs (convulsions), convulsions, and coma. The common name is "convulsion" or "convulsion". It can occur in any season, and it is generally seen in infants and young children. The inc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P25/08
CPCA61K36/185A61P25/08A61K2236/333A61K2236/51A61K2236/53A61K2236/55
Inventor 刘增根岳会兰邵贇陶燕铎
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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