Application of iota-calaratetraose in alleviating metabolic syndrome and preparing related products

A technology for metabolic syndrome and carrageenan, which is applied in the application field of ι-carrageenan in alleviating metabolic syndrome and preparing related products, can solve the problems of biological activity limitation, low bioavailability of ι-carrageenan, and the like, Achieve the effect of improving metabolic syndrome, inhibiting islet β-cell apoptosis, and reducing lipid disorders

Active Publication Date: 2022-01-04
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the low bioavailability of iota-carrageenan, the development of its biological activity has been limited

Method used

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  • Application of iota-calaratetraose in alleviating metabolic syndrome and preparing related products
  • Application of iota-calaratetraose in alleviating metabolic syndrome and preparing related products
  • Application of iota-calaratetraose in alleviating metabolic syndrome and preparing related products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The efficacy of iota-calaratetraose was evaluated in a mouse model of metabolic syndrome induced by a high-sugar and high-fat diet, and it was clarified that it has the effects of lowering blood sugar, improving islet damage, and lowering blood lipids.

[0037] Experimental method: Male C57BL / 6J mice, 6-8 weeks old, 16-18g, were induced by a high-sugar and high-fat diet to establish a model of metabolic syndrome. After 1 week of adaptive feeding, the mice were randomly divided into 4 groups (8 mice in each group): normal group (N, normal saline), model group (M, normal saline), low-dose ι-carotetraose intervention group (ιCTs -L, 30mg / kg.bw), the high-dose ι-carotetraose intervention group (ιCTs-H, 90mg / kg.bw). The normal group was given a low-sugar and low-fat diet (LFSD), and the rest of the group was given a high-sugar and high-fat diet (HFSD). All mice were intervened by intragastric administration (the dose was 10 mL / kg, once a day), and the experimental period wa...

experiment example 2

[0049] Using iota-calaratetraose as the efficacy factor, it is compatible with other oligosaccharides or polysaccharides that have the effects of lowering blood sugar and promoting intestinal peristalsis, and designing 1 or 2 kinds of compositions that can improve insulin resistance.

[0050] Design basis: ① ι-cararatetraose, which has the effect of improving insulin resistance according to Example 1; ② oligochitosaccharides, derived from the shells of shrimp, crab and other crustaceans in nature. The degree of polymerization is 6-8, the molecular weight is 1500Da, good water solubility, easy to be absorbed, and has been proved by research to have the effect of lowering blood sugar; ③Fucoidan (molecular weight 200KDa), widely distributed in kelp, hijiki, rat tail Grass is a water-soluble heteropolysaccharide containing fucose and sulfate groups, which has the effect of regulating blood lipid and blood sugar. ④Inulin (polymerization degree 2-60), a chain-like fructan, is widely...

Embodiment 3

[0056] The efficacy of the composition obtained in Example 2 was verified by a mouse model of metabolic syndrome.

[0057] Experimental method: Male C57BL / 6J mice, 6-8 weeks old, 16-18g, were induced by a high-sugar and high-fat diet to establish a mouse model of metabolic syndrome. After adaptive feeding for 1 week, mice were randomly divided into 4 groups (5 in each group): normal group (N, normal saline), model group (M, normal saline), composition 1 group (composition 1,58mg / kg.bw), composition 2 group (composition 1, 58mg / kg.bw). The normal group was given a low-sugar and low-fat diet (LFSD), and the rest of the group was given a high-sugar and high-fat diet (HFSD). All mice were intervened by intragastric administration (the dose was 10 mL / kg, once a day), and the experimental period was 16 weeks.

[0058] At the 15th week of the experiment, the mice were fasted for 8 hours and administered glucose (2 g / kg·bw) for oral glucose tolerance testing. At the 16th week of t...

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Abstract

The invention discloses an application of iota-calaratetraose and a composition containing iota-calaratetraose in improving metabolic syndrome. The iota-calaratetraose can alleviate metabolic syndrome by improving blood sugar homeostasis, inhibiting the apoptosis of pancreatic beta cells, and reducing lipid disorders. The composition contains marine active oligosaccharides or polysaccharides such as iota-calaratetraose, chitooligosaccharides, and fucoidan, as well as dietary fibers such as inulin and fructooligosaccharides, which can synergistically lower blood sugar and effectively relieve metabolic syndrome. The iota-carrageenan and the composition thereof described in the present invention are safe, effective and inexpensive in improving metabolic syndrome, and at the same time realize the high-value development and utilization of the iota-carrageenan.

Description

technical field [0001] The invention belongs to the technical field of functional foods, and specifically relates to the application of iota-calaratetraose in alleviating metabolic syndrome and preparing related products. Background technique [0002] Metabolic syndrome is a metabolic disorder syndrome with insulin resistance, lipid abnormalities (hypercholesterolemia and dyslipidemia), hypertension, and inflammation as the main risk factors. Metabolic syndrome is an epidemic disease that poses a major threat to global public health, especially in developing countries, due to dramatic changes in dietary patterns and lifestyles, such as excessive intake of high-sugar and high-fat foods, sedentary inactivity, irregular Unhealthy lifestyles such as work and rest, the above factors have caused the incidence of metabolic syndrome to continue to rise. At present, the prevalence rate of metabolic syndrome in our country can reach 21.9%. Metabolic syndrome is combined with other d...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/702A61K31/722A61K31/715A61K31/733A61P3/00A61P3/06A61P9/12A61P5/50A61P29/00
CPCA61K31/702A61K31/722A61K31/715A61K31/733A61P3/00A61P3/06A61P9/12A61P5/50A61P29/00A61K2300/00
Inventor 王静凤李延琪田迎樱常耀光张雷
Owner OCEAN UNIV OF CHINA
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