Acellular matrix-cell composite particles for hair growth and preparation method

Abstract

The invention belongs to the technical field of biological medicines, and particularly relates to acellular matrix-cell composite particles for hair growth and a preparation method. The preparation method comprises the following steps: preparing a dermal acellular matrix microcarrier by using a dermal tissue sample, culturing hair papilla cells into clusters, inoculating epidermal cells, and keeping culturing to prepare the acellular matrix microcarrier-cell composite particles simulating a hair follicle structure. The hair follicle precursor structure is constructed in vitro, and the hair follicle precursor structure is injected into the subcutaneous part of a patient to grow hair, the wound is small, rapid recovery is achieved, the pain time is shortened, and the infection possibility isreduced; the hair density can be obviously increased, and the grown hair can be kept for several years; and the hair follicle precursor structure can be repeatedly applied, the hair density is kept constant, and the problem of insufficient hair in a supply area of an alopecia patient is thoroughly solved.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to an acellular matrix-cell composite particle for hair growth and a preparation method thereof. Background technique [0002] Alopecia disease is common disease, frequently-occurring disease in dermatology, only my country's alopecia population just exceeds 250 million. The survey shows that the age of onset of hair loss in China is between 20 and 40 years old, and the disease progresses fastest when it is about 30 years old. Due to life stress, environmental pollution and changes in dietary structure, compared with the previous generation, the current average age of hair loss is nearly 20 years earlier, and the prevalence rate increases significantly with age. Hair loss can be subdivided into androgenetic alopecia, neurogenic alopecia, nutritional alopecia, chemical alopecia, infectious alopecia, physical alopecia, etc. according to the cause. More than 90% of th...

AI Technical Summary

Problems solved by technology

They all regulate the body's hormones and metabolism levels from the perspective of traditional Chinese medicine, and the effect is not ideal.

The disadvantage of drug therapy is that it needs to be taken for life, and the patient needs to bear a series of adverse reactions

Therefore, the high-generation dermal papilla cells cultured in vitro cannot induce hair follicle regeneration due to the loss of the characteristics of agglutinative growth.

In addition, the position of the dermal papilla is special, and the disadvantages such as difficulty in obtaining it make it difficult to realize the concept of growing new hair by inoculating the dermal papilla.

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