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Oral care composition comprising organophosphate and humulus lupulus extract

The technology of hop extract and organophosphate ester is applied in the field of oral care, which can solve the problems of low bioavailability of active ingredients, affecting the retention amount and retention time of hop extract, and achieve the effect of increasing the retention amount.

Active Publication Date: 2021-02-02
HAWLEY & HAZEL BVI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Although hop extracts have been frequently used in oral care compositions, existing oral care products, such as toothpaste, mouthwash, etc., generally only have a use time of 1-3 minutes, and active ingredients such as hop extracts will also disappear after use. Washed away with toothpaste paste or mouthwash, this way of use affects the amount and residence time of hop extract on the tooth surface, making the bioavailability of active ingredients extremely low

Method used

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  • Oral care composition comprising organophosphate and humulus lupulus extract
  • Oral care composition comprising organophosphate and humulus lupulus extract
  • Oral care composition comprising organophosphate and humulus lupulus extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-4、 comparative example 1-4

[0104] An oral care composition comprising organophosphate and hop extract, including the raw materials in the following table 1 ratio, the total amount is prepared into toothpaste by 100 parts;

[0105] Table 1:

[0106]

[0107]

[0108] The above-mentioned 8 corresponding toothpastes were detected according to the residual active ingredient of the above-mentioned hop extract, and the data are shown in Table 2 below:

[0109] Table 2:

[0110]

[0111] It can be seen from the above Table 1 and Table 2 that when organic phosphate is added to the oral care composition, the retention amount of the hop extract on the tooth surface can be significantly increased.

Embodiment 5-9、 comparative example 5-6

[0113] An oral care composition comprising hop extracts, including the raw materials in the following table 3 proportioning, the total amount is prepared into toothpaste by 100 parts;

[0114] table 3:

[0115]

[0116] The toothpaste prepared in Table 3 is detected according to the residual active ingredient of the above-mentioned hop extract, and the data are shown in Table 4 below:

[0117] Table 4:

[0118]

[0119] Can find out from above-mentioned table 3 and table 4: when adding organophosphate ester in oral care composition, can significantly improve the retention amount of hop extract on tooth surface; And, when the content ratio of organophosphate ester and hop extract is greater than When the content ratio is 22:3, the increase in retention is more significant; when the content ratio is greater than 40:3, the increase in retention is extremely significant; when the content ratio is greater than 20:1, the increase in retention is most significant.

Embodiment 10-15、 comparative example 7-8

[0121] An oral care composition comprising hop extracts, including the raw materials in the following table 5 ratio, the total amount is prepared into toothpaste by 100 parts;

[0122] table 5:

[0123]

[0124] The toothpaste prepared in Table 5 is detected according to the residual active ingredient of the above-mentioned hop extract, and the data are shown in Table 6 below:

[0125] Table 6:

[0126]

[0127] As can be seen from the above Table 5 and Table 6: when organic phosphate is added to the oral care composition, and when the content ratio of organic phosphate and hop extract is less than 5:1, the retention of beta acid is not significantly improved; When the content ratio is greater than 5:1, the retention capacity increases significantly; when the content ratio is greater than 10:1, the retention capacity increases extremely significantly; when the content ratio is greater than 20:1, the retention capacity increases most significantly.

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Abstract

The invention discloses an oral care composition comprising an organophosphate and humulus lupulus extract. The oral care composition comprises the humulus lupulus extract, the organophosphate and anorally acceptable carrier; an organic acid ester compound has the following general structure, where R1 represents alkyl with 6 to 16 carbon atoms; m is 2 or 3, and n is 1 to 4; and Z2 or Z3 can be the same or different and are respectively selected from hydrogen, alkali metal or ammonium. The oral care composition provided by the invention can significantly improve the retention amount of the humulus lupulus extract on the tooth surface.

Description

technical field [0001] The present invention relates to the technical field of oral care, in particular to an oral care composition comprising organophosphate and hop extract. Background technique [0002] Hops are from Cannabaceae (Humulus lupulus Linn.) and belong to the genus Mulberry. It is a perennial entwining herb. Hops are mainly distributed in the northern hemisphere, in the area between 30°-60° north latitude, concentrated in Europe, Asia and North America, and only 1 variant is distributed in Morocco, North Africa. There are also northern and northeastern Asia and eastern America. China is mainly concentrated in Xinjiang, Gansu and other places. Hops extract means an extract obtained from the extraction of dried flowers, vines, vines or other parts of the plant by any method known in the art, or a synthetic or semi-synthetic equivalent of such an extract or its active components thing. Extracts are commercially available, eg, from Steiner, HAAS. [0003] Hops...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/55A61Q11/00
CPCA61K8/9789A61K8/55A61Q11/00
Inventor 黄美艳李艳晓岳红雷丁学芬
Owner HAWLEY & HAZEL BVI
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