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Cell sorter based on inclined optical fiber grating optical tweezers

A technology of tilting fiber grating and cell sorting instrument, which is applied in the fields of biomedical photonics and cell analysis, can solve the problems of unstable mechanical strength, easily affected by the environment, fragile micro-nano fiber structure, etc., and achieves high stability. , the effect of simple structure

Active Publication Date: 2021-01-29
NANKAI UNIV
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the structure of micro-nano fiber is fragile, its mechanical strength is unstable, and its performance is easily affected by the environment.
At present, there is no stable structure and stable performance of a large number of particle capture solutions to achieve high-efficiency particle sorting

Method used

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  • Cell sorter based on inclined optical fiber grating optical tweezers
  • Cell sorter based on inclined optical fiber grating optical tweezers
  • Cell sorter based on inclined optical fiber grating optical tweezers

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Embodiment

[0034] The working wavelength band of the light source 2 is 1550nm. The working band of the erbium-doped fiber amplifier 3 is 1500-1600nm, and the average gain is 20dB. The central wavelength of the electro-optic modulator 4 is 1550 nm, the modulation bandwidth is 20 GHz, the modulation frequency is 100 MHz, and the extinction ratio is 250:1. The central wavelength of the polarization controller 5 is 1550 nm, and the insertion loss is 0.7 dB. The central wavelength of the large-angle tilted fiber Bragg grating 9 is 1550 nm, and the spatial diffraction efficiency of the central wavelength is >15 dB.

[0035] In practical application, the polarization controller 5 is adjusted to make the light emitted by the light source 2 produce the highest diffracted light efficiency when the fiber Bragg grating 9 is tilted at a large angle. Adjust the erbium-doped fiber amplifier 3 so that the output power of the diffracted light trap is higher than the capture threshold of cells with a sp...

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Abstract

The invention belongs to the field of biomedical photonics, and particularly relates to a cell sorter based on inclined optical fiber grating optical tweezers. The cell sorter comprises a computer, alight source, an erbium-doped fiber amplifier, a modulator, a polarization controller, a micro-driver, a microscope, a micro-flow control chip and an inclined Bragg fiber grating, light emitted by thelight source is amplified in energy through the erbium-doped fiber amplifier, the light intensity is controlled through the modulator, then the light enters the inclined Bragg fiber grating through apolarization controller for filtering polarized light, the light forms a light trap through the inclined Bragg fiber grating, the micro-flow control chip is arranged at the light trap generation position, the microscope is used for observing the micro-flow control chip, and the computer is used for controlling the light source, the erbium-doped fiber amplifier, the modulator, the polarization controller and the micro-driver.

Description

technical field [0001] The invention belongs to the field of biomedical photonics, and more specifically relates to a cell sorter based on inclined fiber grating optical tweezers, especially for cell sorting of multi-cell samples in the field of biomedicine, and can be used for cell analysis and disease diagnosis and other fields. Background technique [0002] Cell sorting is the separation of one type of cell from a multicellular sample. Cell sorting is a very important and indispensable basic technology in cell biology. Cell sorting has been widely used in drug screening and intracellular gene expression in the field of cell analysis, which has important practical significance for biological research and medical clinical testing. [0003] At present, there are various technical means for cell sorting, including fluorescence activated cell sorting, magnetic manipulation sorting, two-dimensional electrophoresis sorting, optical tweezers sorting, ultrasonic sorting, mechani...

Claims

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Application Information

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IPC IPC(8): C12M1/00C12M1/36B01L3/00
CPCC12M23/16C12M41/06B01L3/502761
Inventor 林炜孙心昀刘波战晓寒李保洁刘海锋张昊
Owner NANKAI UNIV
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