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Shape memory polymer material for esophagus stent and its preparation and application method

A memory polymer and control method technology, applied in the field of polymer materials, can solve problems such as difficult implantation positions, precise adjustments, tissue thermal damage, etc., and achieve the effects of simple preparation process, high application prospects, and high tensile stress

Active Publication Date: 2021-09-17
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the shape memory materials reported so far still face many shortcomings, making it difficult to apply to the human body.
First of all, the shape memory response temperature of most current shape memory polymer materials is much higher than the normal body temperature of the human body, so that they cannot be triggered to expand by themselves after being implanted in the human body to realize the support of the esophagus
The use of additional heating methods will not only bring the risk of tissue thermal damage to the patient, but also increase the complexity of the stent implantation process
Secondly, the shape memory behavior of most current shape memory materials is irreversible, which makes it difficult to precisely adjust the implantation position once the material is triggered to self-deploy after being implanted in the human body.

Method used

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  • Shape memory polymer material for esophagus stent and its preparation and application method
  • Shape memory polymer material for esophagus stent and its preparation and application method
  • Shape memory polymer material for esophagus stent and its preparation and application method

Examples

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Effect test

preparation example Construction

[0081] 5. Application of the shape memory polymer material made by the preparation method of the shape memory polymer material

[0082] Application of shape memory polymer materials in esophageal stents.

[0083] Embodiments of the present invention are as follows:

Embodiment 1

[0085] 331.0 mg of polytetrahydrofuran diacrylate, 220.4 mg of polyethylene glycol diacrylate, 45.8 mg of pentaerythritol tetra-3-mercaptopropionate, and 5.5 mg of benzoin dimethyl ether were dissolved in 1.1 ml of chloroform solution. After ultrasonically obtaining a uniform transparent precursor solution, inject the precursor solution into the transparent mold, remove air bubbles, and seal. Place the mold under a 365nm ultraviolet lamp for cross-linking and polymerization for 1.5 hours, then take out the fully cross-linked polymer from the mold and vacuum-dry it in a 40°C oven to constant weight to obtain a two-way reversible shape memory with human body temperature response and human body temperature, Water-responsive triple shape-memory polymer material.

[0086] The polytetrahydrofuran diacrylate used in this example has a molecular weight of 2900 g / mol and a melting point of 26.0 °C. The polyethylene glycol diacrylate used had a molecular weight of 4000 g / mol and a melt...

Embodiment 2

[0095] 275.4 mg of polytetrahydrofuran diacrylate, 274.9 mg of polyethylene glycol diacrylate, 43.9 mg of pentaerythritol tetra-3-mercaptopropionate, and 5.5 mg of benzoin dimethyl ether were dissolved in 1.1 ml of chloroform solution. After ultrasonically obtaining a uniform transparent precursor solution, inject the precursor solution into the transparent mold, remove air bubbles, and seal. Place the mold under a 365nm ultraviolet lamp for cross-linking polymerization for 1.5 hours, then take out the fully cross-linked polymer from the mold and vacuum-dry it in a 40°C oven to constant weight to obtain a two-way reversible shape memory with human body temperature response and human body temperature, Water-responsive triple shape memory polymer material. The material exhibits good two-way shape memory properties between -20 °C and 37 °C, with a reversible strain of 9.73%.

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Abstract

The invention discloses a shape-memory polymer material used for esophageal support and a preparation method thereof. The present invention is prepared by polymerizing a hydrophilic crystallizable macromonomer, a hydrophobic crystallizable macromonomer and a cross-linking agent, and the mass ratio of the three is: 30-60, 40-70, ~10 parts; the hydrophilic crystallizable macromer is polyethylene glycol diacrylate, and the hydrophobic crystallizable macromonomer is polytetrahydrofuran diacrylate; the crosslinking agent is pentaerythritol tetra-3-mercapto propionate. The material of the invention is simple to prepare, light and soft in texture, and degradable. When used as an esophageal stent material, it has the ability of self-deployment, adjustment, and sustained drug release in the human body environment, showing high application prospects.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to a shape-memory polymer material used for esophageal stents, a preparation method and an application method thereof. Background technique [0002] Esophageal cancer is a cancer with a high incidence in my country, and the five-year survival rate of patients is less than 15%. Esophageal stent implantation is an important means of palliative treatment for patients with advanced esophageal cancer. However, traditional esophageal stent materials commonly used in clinical practice are mostly metal materials, which will cause greater pain to patients because of their high rigidity after being implanted into the human body. Metal stents are difficult to degrade and face problems of rectification and recycling once released in the human body. In addition, the traditional esophageal stent can only play a simple supporting role, and can only relieve the symptoms of e...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/06A61L31/14C08F299/02
CPCA61L31/06A61L31/14A61L2400/16C08F2/48C08F299/024C08F299/028C08L71/02
Inventor 俞豪杰梁瑞雪王立
Owner ZHEJIANG UNIV
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