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Zinc-doped porous bioactive glass ceramic and preparation method thereof

A bioactive glass and ceramic technology, applied in tissue regeneration, medical science, prosthesis, etc., can solve the problems of secondary fracture, elevation, change, etc., to promote the formation of new bone, improve the mechanical strength, and accelerate the reconstruction process Effect

Pending Publication Date: 2021-01-01
GANNAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the existing calcium-magnesium-silicon bioactive glass ceramics have insufficient biological activity, and the degradation rate is too fast. The degraded position of the material is filled with a large amount of granulation tissue without load-bearing capacity, which easily causes secondary fractures.
[0005] In addition, the existing calcium-magnesium-silicon bioactive glass-ceramic materials cause a rapid increase in pH when degraded in vivo and in vitro, resulting in changes in the pH of the surrounding microenvironment, which is not conducive to the growth of surrounding tissues and cells

Method used

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  • Zinc-doped porous bioactive glass ceramic and preparation method thereof
  • Zinc-doped porous bioactive glass ceramic and preparation method thereof
  • Zinc-doped porous bioactive glass ceramic and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Step S1: Prepare Zn-AW precursor powder (such as figure 1 shown)

[0041] According to the molar ratio of 2.5:1, weigh tetraethyl orthosilicate (TEOS) and triethyl phosphate (TEP) and dissolve them in absolute ethanol solution (the molar ratio of TEOS to absolute ethanol is 6:7), and make it mix well;

[0042] Weigh Mg(NO 3 ) 2 , Ca(NO 3 ) 2 , NH 4 HF 2 and Zn(NO 3 ) 2 , and dissolved in water (water and Ca(NO 3 ) 2 The molar ratio is 6:1) to obtain an inorganic solution, slowly add the inorganic solution dropwise to the above organic solution, and add HNO 3 Adjust the pH value of the mixed solution to 1.0, stir until a stable sol is formed, age at room temperature for 24 hours, put it into liquid nitrogen for rapid cooling, then transfer it to a vacuum freeze dryer, and fully freeze-dry it at -40°C to obtain zinc-containing Xerogel powder. The dry gel powder was calcined at 800°C and ball milled through a 200-mesh sieve to obtain the precursor powder.

[00...

Embodiment 2

[0047] Step S1: Preparation of Zn-AW precursor powder

[0048] According to the molar ratio of 2.5:1, weigh tetraethyl orthosilicate (TEOS) and triethyl phosphate (TEP) and dissolve them in ethanol solution (the molar ratio of TEOS to absolute ethanol is 6:7), and mix them well ;

[0049] Weigh Mg(NO 3 ) 2 , Ca(NO 3 ) 2 , NH 4 HF 2 and Zn(NO 3 ) 2 , and dissolved in water (water and Ca(NO 3 ) 2 The molar ratio is 6:1) to obtain an inorganic solution, slowly add the inorganic solution dropwise to the above organic solution, and add HNO 3 Adjust the pH value of the mixed solution to 1.3, stir until a stable sol is formed, age at room temperature for 24 hours, put it into liquid nitrogen for rapid cooling, then transfer it to a vacuum freeze dryer, and fully freeze-dry at -40°C to obtain zinc-containing dry powder. Gel powder. The dry gel powder was calcined at 800°C and ball milled through a 200-mesh sieve to obtain the precursor powder.

[0050] Step S2: Preparatio...

Embodiment 3

[0054] Step S1: Preparation of Zn-AW precursor powder

[0055] According to the molar ratio of 2.5:1, weigh tetraethyl orthosilicate (TEOS) and triethyl phosphate (TEP) and dissolve them in ethanol solution (the molar ratio of TEOS to absolute ethanol is 6:7), and mix them well ;

[0056] Weigh Mg(NO 3 ) 2 , Ca(NO 3 ) 2 , NH 4 HF 2 and Zn(NO 3 ) 2 , and dissolved in water (water and Ca(NO 3 ) 2 The molar ratio is 6:1) to obtain an inorganic solution, slowly add the inorganic solution dropwise to the above organic solution, and add HNO 3 Adjust the pH value of the mixed solution to 1.3, stir until a stable sol is formed, age at room temperature for 24 hours, put it into liquid nitrogen for rapid cooling, then transfer it to a vacuum freeze dryer, and fully freeze-dry at -40°C to obtain zinc-containing dry powder. Gel powder. The dry gel powder was calcined at 800°C and ball milled through a 200-mesh sieve to obtain the precursor powder.

[0057] Step S2: Preparatio...

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Abstract

The invention discloses a zinc-doped porous bioactive glass ceramic and a preparation method thereof. Zn(NO3)2 serves as a zinc source, and the Zn element participates in a reaction system in the rawmaterial stage, so that uniform distribution of the Zn element in the system is facilitated. Due to the addition of a proper amount of the zinc element in the porous bioactive glass ceramic, the mechanical strength of a porous bioactive glass ceramic material is improved, and after the material is implanted into the body, the Zn element in the material can be continuously and slowly released intosurrounding body fluid and further plays a beneficial role in expression of osteoblast related protein, and finally the formation of new bones is induced and promoted to accelerate the reconstructionprocess of bone defect / injury parts.

Description

technical field [0001] The invention belongs to the field of bone repair medical materials, and in particular relates to a porous bioactive glass ceramic doped with zinc element and a preparation method thereof. Background technique [0002] Bioglass is a silicate-based heterogeneous bone graft material that can form an osseous bond with bone tissue and promote new bone formation. When the bioglass is implanted into the bone defect, a rapid ion exchange reaction will occur between the bioglass and the body fluid, and a carbonate-containing hydroxyapatite layer will be formed on the surface of the bioglass. Through this bone-like hydroxyapatite layer, the material Forms a strong chemical bond with bone. Compared with bioinert ceramics, bioglass has unique biocompatibility, osteogenesis and osteoconduction, but its low mechanical strength and high brittleness limit its application fields to a certain extent. [0003] Bioglass-ceramic composites are composite materials prep...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/10A61L27/56A61L27/54A61L27/02A61L27/50
CPCA61L27/10A61L27/56A61L27/54A61L27/025A61L27/50A61L2430/02A61L2300/102A61L2300/412A61L2300/602
Inventor 张翔甘滔周丽丽李坊佐彭诗珍彭维杰易章林
Owner GANNAN MEDICAL UNIV
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