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Application of anemoside B4 in preparation of drugs for treating ulcerative colitis

A technology of ulcerative colitis and Pulsatilla saponin, which is applied in the application field of Pulsatilla saponin B4 in the preparation of medicines for treating ulcerative colitis, can solve the problems that the therapeutic effect has not been reported, and achieve low toxic and side effects, definite curative effect, and solve the curative effect Insufficient effect

Pending Publication Date: 2020-12-22
SOUTH CHINA UNIV OF TECH
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  • Claims
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AI Technical Summary

Problems solved by technology

Pulsatilla saponin B4 (Anemoside B4, AB4) is the main component of Pulsatilla genus Pulsatilla, Ranunculaceae. It has anti-inflammatory, anti-cytotoxic, anti-tumor and other biological activities, but its therapeutic effect on UC has not been reported yet.

Method used

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  • Application of anemoside B4 in preparation of drugs for treating ulcerative colitis
  • Application of anemoside B4 in preparation of drugs for treating ulcerative colitis
  • Application of anemoside B4 in preparation of drugs for treating ulcerative colitis

Examples

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Effect test

Embodiment 1

[0026] 1. Mice (purchased from Hunan Slack Jingda Experimental Animal Co., Ltd., Changsha, China) were randomly divided into 7 groups, with 4 mice in each group. Dextran sulfate (DSS) was used to induce symptoms of ulcerative colitis in mice, and then the mice were administered in groups, and the relief and therapeutic effects of the drugs in each group were investigated with the relief of inflammation in the mice after administration as an index. The experimental settings for each group are as follows:

[0027] (1) Normal group: during the experiment period (18 days), they were given free drinking water, and no drugs were added to the diet.

[0028] (2) Model group (DSS group): Use 2% (w / v) DSS circulation to induce ulcerative colitis in mice. Modeling method: Dissolve DSS in drinking water at a concentration of 2% (w / v) , wherein, the 1st-4, 8-11 and 15-18 days give 2% (w / v) DSS solution respectively; The 5th-7 and 12-14 days give water, the 19th day finishes experiment ( ...

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Abstract

The invention discloses application of anemoside B4 in preparation of drugs for treating ulcerative colitis. The anemoside B4 can be used for remarkably relieving symptoms of a model mouse suffering from the ulcerative colitis, has an action superior to that of a latest UC Western medicine Tofacitinib and that of a traditional Chinese medicine monomer berberine having a relatively large treatmentprospect to the UC, cannot cause spleen swelling accompanying during treatment on the UC by the two kinds of medicines, has a certain relieving action on the spleen swelling and meanwhile is free of structural impairment to other internal organs. The anemoside B4 is definite in UC treatment effect, low in toxic or side effects and high in safety and is advantageously applied to clinical treatmenton the UC, and problems of the existing medicines that the treatment effect is insufficient, side effects are high, and the toxicity is high are solved.

Description

technical field [0001] The invention relates to the application of Pulsatilla saponin B4, in particular to the application of Pulsatilla saponin B4 in the preparation of medicines for treating ulcerative colitis. Background technique [0002] Ulcerative colitis (Ulcerative colitis, UC) is a chronic inflammatory bowel disease that occurs in the colon. The pathogenesis of ulcerative colitis is unknown, involving genetic susceptibility, epithelial barrier defects, immune response dysregulation, and environmental factors. Clinical treatment drugs are mainly anti-inflammatory drugs, corticosteroids, biological agents and immunosuppressants. However, most of these drugs have serious side effects, and the patient's cure rate is low and easy to repeat. Tumor necrosis factor TNF-α antibody has been widely used in the past two decades, but there are problems such as high toxicity and side effects, high price, and the route of administration is intramuscular or subcutaneous injection....

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P1/00A61P1/04
CPCA61K31/704A61P1/00A61P1/04
Inventor 李艳红韩倩唐华争邹敏
Owner SOUTH CHINA UNIV OF TECH
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