A preparation method of temperature-responsive bacterial cellulose antibacterial nanogel

A bacterial cellulose and temperature-responsive technology, which is applied in the direction of antibacterial drugs, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc. Inconvenience and other problems, to achieve good biocompatibility and temperature-sensitive reactivity, to achieve long-term release, high antibacterial efficiency

Active Publication Date: 2021-11-02
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve at least one of the above problems, the present invention provides a method for preparing a temperature-responsive bacterial cellulose antibacterial nanogel, which uses the temperature-sensitive characteristics of the antibacterial nanogel to achieve precise coverage of antibacterial materials at specific locations and antibacterial agents The sustained-release effect of the drug can solve the shortcomings of inconvenient drug administration at some bacterial infection sites, easy loss of liquid medicine and low utilization rate of antibacterial agents

Method used

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  • A preparation method of temperature-responsive bacterial cellulose antibacterial nanogel
  • A preparation method of temperature-responsive bacterial cellulose antibacterial nanogel
  • A preparation method of temperature-responsive bacterial cellulose antibacterial nanogel

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Embodiment 1

[0050] A method for preparing a temperature-responsive bacterial cellulose antibacterial nanogel, comprising the steps of:

[0051] (1) The preparation method of bacterial cellulose nano whisker suspension:

[0052] Take the bacterial cellulose suspension with a solid content of 2.11% and freeze-dry (-60°C for 24h) to obtain bacterial cellulose; then add 1g of bacterial cellulose to 100mL 70% sulfuric acid solution and stir at 60°C for 12 hours, and the solution after stirring Dialyze with water (molecular cut-off value 8000u, dialysis for 3 days), after dialysis, freeze-dry (freeze at -60°C for 24h) to obtain bacterial cellulose nano-whisker powder; weigh bacterial cellulose nano-whisker powder and disperse it in water and stir Uniformly prepare bacterial cellulose nano-whisker suspensions with a solid content of 0.75% bacterial cellulose nano-whiskers;

[0053] (2) Tris (hydroxymethyl) aminomethane buffer solution is added in the bacterial cellulose nano whisker suspension ...

Embodiment 2

[0057] A method for preparing a temperature-responsive bacterial cellulose antibacterial nanogel, comprising the steps of:

[0058] (1) The preparation method of bacterial cellulose nano whisker suspension is:

[0059] The bacterial cellulose suspension with a solid content of 2.11% was freeze-dried (-60°C for 24h) to obtain bacterial cellulose; 1g of bacterial cellulose was added to 100mL of 50% sulfuric acid solution and stirred at 60°C for 12 hours. After stirring, the solution was Water dialysis (molecular cut-off value 8000u, dialysis for 3 days), after dialysis, freeze-dry at -60°C for 24 hours to obtain bacterial cellulose nano-whisker powder; weigh bacterial cellulose nano-whisker powder and disperse in water and stir evenly to obtain bacterial fiber Suspension of bacterial cellulose nano-whiskers with a solid content of 0.5%.

[0060] (2) Tris (hydroxymethyl) aminomethane buffer solution is added in the bacterial cellulose nano whisker suspension in 10mL step (1), wh...

Embodiment 3

[0064] A method for preparing a temperature-responsive bacterial cellulose antibacterial nanogel, comprising the steps of:

[0065] (1) The preparation method of bacterial cellulose nano whisker suspension is:

[0066] The bacterial cellulose suspension with a solid content of 2.11% was freeze-dried (-60°C for 24h) to obtain bacterial cellulose; 1g of bacterial cellulose was added to 100mL of 50% sulfuric acid solution and stirred at 60°C for 6 hours. After stirring, the solution was Water dialysis (molecular cut-off value 8000u, dialysis for 3 days), after dialysis, freeze-dry at -60°C for 24 hours to obtain bacterial cellulose nano-whisker powder; weigh bacterial cellulose nano-whisker powder and disperse in water and stir evenly to obtain bacterial fiber Suspension of bacterial cellulose nano-whiskers with a solid content of 0.2%.

[0067] (2) Tris (hydroxymethyl) aminomethane buffer solution is added in the bacterial cellulose nano whisker suspension in 10mL step (1), whe...

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Abstract

The invention discloses a method for preparing a temperature-responsive bacterial cellulose antibacterial nanogel, which belongs to the field of nanomaterial preparation. The method for preparing temperature-responsive bacterial cellulose antibacterial nanogel of the present invention is based on bacterial cellulose nano-whiskers, by mixing bacterial cellulose nano-whisker suspensions loaded with haloamine antibacterial agents on the surface with temperature-sensitive It is prepared by uniformly mixing permanent poly N-isopropylacrylamide. The method of the invention is simple and easy, and the prepared gel exhibits different antibacterial agent release effects and rheological properties at different temperatures, and has good application prospects in the field of biomedical materials, especially injectable gel materials.

Description

technical field [0001] The invention relates to a method for preparing a temperature-responsive bacterial cellulose antibacterial nanogel, which belongs to the field of nanomaterial preparation. Background technique [0002] For the treatment of bacterial infections in some body organs that are not easy to administer, such as ear, nose, mouth and bacterial infections in the body, it is necessary to design appropriate antibacterial drug carriers to achieve effective therapeutic effects. Designing antibacterial carriers with specific sensitivity to achieve accurate release of antibacterial drugs at the infection site can not only improve bioavailability but also reduce the impact of antibacterial materials on normal tissues outside the infection site. [0003] Responsive nanoscale smart materials have great application potential in the field of biomedical materials. Nanogel is a kind of nanomaterial with high specific surface area, and its nanostructure helps to realize the e...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K47/38A61K47/32A61K31/4166A61P31/04
CPCA61K9/0014A61K9/0019A61K9/0043A61K9/0046A61K9/0053A61K9/06A61K31/4166A61K47/32A61K47/38A61P31/04
Inventor 任学宏张淑敏刘颖李蓉栗志广
Owner JIANGNAN UNIV
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