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Magnesium slow-release bone cement with self-curing function and preparation method thereof

A bone cement, self-curing technology, applied in medical science, tissue regeneration, prosthesis, etc., can solve the problems of fast magnesium degradation, poor bone ability, difficult to control the slow release rate of magnesium, etc., to avoid bone cement to promote bone. Poor ability, good biocompatibility, avoiding the effect of calcium phosphate bone cement disintegration

Pending Publication Date: 2020-12-08
THE UNIV OF HONG KONG SHENZHEN HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In view of this, the purpose of the present invention is to provide a magnesium slow-release bone cement with self-curing function, which solves the problem that the degradation rate of magnesium in the existing magnesium-containing bone cement is relatively fast and it is difficult to control the slow-release rate of magnesium, resulting in The calcium phosphate bone cement containing magnesium or magnesium oxide disintegrates quickly in the presence of water and the bone cement has poor bone formation ability

Method used

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  • Magnesium slow-release bone cement with self-curing function and preparation method thereof
  • Magnesium slow-release bone cement with self-curing function and preparation method thereof
  • Magnesium slow-release bone cement with self-curing function and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The magnesium slow-release bone cement with self-curing function provided in Example 1 is made by mixing and solidifying powder and water according to the ratio of mass to volume of 1g:0.5ml. The powder is calculated by mass percentage and includes the following raw materials Components: 2.86g of tetracalcium phosphate, 0.8g of calcium hydrogen phosphate, and 0.34g of magnesium phosphate; the aqueous solution is calculated by mass percentage, and includes the following raw materials: 1g of citric acid, 1g of polyvinylpyrrolidone, and 8ml of deionized water.

[0037] The magnesium slow-release bone cement with self-curing function provided in Example 1 is realized through the following steps:

[0038] S1. Preparation of powder: Weigh 2.92g of tetracalcium phosphate, 1.08g of calcium hydrogen phosphate, and 0.1g of magnesium phosphate in sequence, stir and mix thoroughly to obtain powder;

[0039] S2. Preparation of water preparation: Measure 8ml of deionized water, weigh...

Embodiment 2

[0042] A magnesium slow-release bone cement with self-curing function provided in Example 2 is made by mixing and solidifying powder and water according to the ratio of mass to volume of 1g:0.55ml. The powder is calculated by mass percentage and includes the following raw materials Components: 2.86g of tetracalcium phosphate, 0.8g of calcium hydrogen phosphate, and 0.3g of magnesium hydrogen phosphate; the aqueous solution is calculated by mass percentage, and includes the following raw materials: 1.5g of citric acid, 0.8g of polyvinylpyrrolidone, and 7.7ml of deionized water.

[0043]The magnesium slow-release bone cement with self-curing function provided in Example 2 is realized through the following steps:

[0044] S1. Preparation of powder: Weigh 2.86g of tetracalcium phosphate, 0.8g of calcium hydrogen phosphate, and 0.3g of magnesium hydrogen phosphate in sequence, stir and mix well to obtain powder;

[0045] S2. Preparation of water agent: Measure 7.7ml of deionized wa...

Embodiment 3

[0048] The magnesium slow-release bone cement with self-curing function provided in Example 3 is made by mixing and solidifying powder and water according to the ratio of mass to volume of 1g:1ml. The powder is calculated by mass percentage and includes the following raw material groups Composition: 2.86g of tetracalcium phosphate, 0.8g of calcium hydrogen phosphate, 0.3g of magnesium hydrogen phosphate; the aqueous solution is calculated by mass percentage, and includes the following raw materials: 1.5g of citric acid, 0.8g of polyvinylpyrrolidone, and 7.7ml of deionized water.

[0049] The magnesium slow-release bone cement with self-curing function provided in Example 3 is realized through the following steps:

[0050] S1. Preparation of powder: Weigh 2.86g of tetracalcium phosphate, 0.8g of calcium hydrogen phosphate, and 0.3g of magnesium hydrogen phosphate in sequence, stir and mix well to obtain powder;

[0051] S2. Preparation of water agent: Measure 7.7ml of deionized...

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Abstract

The invention discloses magnesium slow-release bone cement with a self-curing function. The magnesium slow-release bone cement is characterized by being prepared by mixing and curing an aqueous solution and powder, wherein the powder comprises the following raw material components in percentage by mass: 60-95% of a calcium phosphate compound and 5-40% of a magnesium compound; and the aqueous solution comprises the following raw materials in percentage by mass: 10-30% of citric acid, 5-20% of polyvinylpyrrolidone and 40-84% of deionized water. According to the magnesium slow-release bone cementdisclosed by the invention, an organic crosslinking agent and specific magnesium salt are simultaneously added as donors for slow-release magnesium ions, so that the magnesium ions are slowly released, and calcium phosphate bone cement disintegration caused by too fast magnesium degradation in the prior art is avoided. In addition, the magnesium slow-release bone cement disclosed by the inventionhas excellent biocompatibility and a certain osteogenesis promoting ability and can well meet the clinical application requirements.

Description

technical field [0001] The invention belongs to the technical field of medical bone cement, and in particular relates to a slow-release magnesium bone cement with self-curing function and a preparation method thereof. Background technique [0002] Calcium phosphate bone cement is expected to be an ideal bone filler for repairing bone defects because it eventually forms hydroxyapatite similar to natural bone components in the body and has good biocompatibility; however, calcium phosphate bone cement The ability to promote osteogenesis is weak; in calcium phosphate bone cement, after adding magnesium or magnesium oxide, the slow release of magnesium can improve the activity of promoting osteogenesis; but due to the rapid degradation of magnesium or magnesium oxide, it is difficult to control the slow release rate of magnesium, and also It will cause the calcium phosphate bone cement containing magnesium or magnesium oxide to disintegrate quickly in the environment with water; ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/02A61L27/54A61L27/50
CPCA61L27/12A61L27/025A61L27/54A61L27/50A61L2430/02A61L2300/102A61L2300/604
Inventor 黄德民杨伟国刘飞宏吴隽邝冠明
Owner THE UNIV OF HONG KONG SHENZHEN HOSPITAL
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