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Enteric coating material and its preparation method and enteric products

An enteric coating material and coating material technology are applied in the coating of sugar-coated pills, pharmaceutical formulas, and food, and can solve the problems of high weight gain rate, low production efficiency, and increased production cost.

Active Publication Date: 2021-07-02
QINGDAO SHENGBANG HEALTH FOOD CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Sodium alginate is also disclosed in the prior art as an enteric coating material. For example, Chinese patent application CN104857520A discloses a sodium alginate coating liquid composition and a coating method thereof, and the weight gain rate of the enteric layer is 7%. -10%, high weight gain rate, long production cycle, low production efficiency and increased production cost

Method used

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  • Enteric coating material and its preparation method and enteric products
  • Enteric coating material and its preparation method and enteric products
  • Enteric coating material and its preparation method and enteric products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: Selection experiment of coating material of isolation layer

[0027] 1. Prepare five kinds of isolation layer coating materials according to the following prescriptions:

[0028] Prescription 1: 1.5 parts by weight of hydroxypropyl methylcellulose, 3 parts by weight of polyacrylic resin II, 2 parts by weight of polyacrylic resin III, 0.5 parts by weight of talcum powder, and 3 parts by weight of polyethylene glycol, dissolved in 80v / v% ethanol solution 90 parts by weight, standby.

[0029] Prescription 2: 4 parts by weight of shellac, 0.5 parts by weight of hydroxypropyl methylcellulose, 2 parts by weight of magnesium stearate, 7 parts by weight of polyethylene glycol, dissolved in 120 parts by weight of 80v / v% ethanol solution, and set aside.

[0030] Prescription 3: 4 parts by weight of corn protein, 0.5 parts by weight of hydroxypropyl methylcellulose, 2 parts by weight of magnesium stearate, 7 parts by weight of polyethylene glycol, dissolved in 120...

Embodiment 2

[0053] Example 2: Experiment on selection of enteric outer coating material

[0054] 1. Formula composition and dosage of coated vegetarian tablet (pueraria tuckahoe pressed tablet candy): 0.5kg kudzu root powder, 0.5kg poria cocos powder, 0.2kg medlar powder, 5kg sodium bicarbonate, Potassium citrate 1kg, xylitol 1.6kg, corn starch 1.1kg, magnesium stearate 0.1kg. Accurately weigh the above-mentioned ingredients in the formula, and go through processes such as granulation, drying, granulation and general blending, and tabletting to obtain a plain tablet with a specification of 0.5 g for future use.

[0055] 2. Prepare the coating material of the isolation layer according to the following formula: 4 parts by weight of shellac, 0.5 parts by weight of hydroxypropyl methylcellulose, 2 parts by weight of magnesium stearate, 7 parts by weight of polyethylene glycol, dissolved in 80v / 120 parts by weight of v% ethanol, for subsequent use.

[0056] 3. Prepare three kinds of enter...

Embodiment 3

[0110] Embodiment 3: the selection experiment of the consumption of parameter in the coating material of isolation layer

[0111] 1. Formula composition and dosage of coated vegetarian tablet (pueraria tuckahoe pressed tablet candy): 0.5kg kudzu root powder, 0.5kg poria cocos powder, 0.2kg medlar powder, 5kg sodium bicarbonate, Potassium citrate 1kg, xylitol 1.6kg, corn starch 1.1kg, magnesium stearate 0.1kg. Accurately weigh the above-mentioned ingredients in the formula, and go through processes such as granulation, drying, granulation and general blending, and tabletting to obtain a plain tablet with a specification of 0.5 g for future use.

[0112] 2. Prepare three kinds of isolation layer coating materials according to the following formula:

[0113] Formula 1: 2 parts by weight of shellac, 0.3 parts by weight of hydroxypropyl methylcellulose, 0.2 parts by weight of magnesium stearate, 4 parts by weight of polyethylene glycol, and 60 parts by weight of 80v / v% ethanol s...

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Abstract

The invention relates to an enteric coating material, a preparation method thereof and an enteric product. The enteric coating material of the present invention includes an isolation layer coating material and an enteric outer layer coating material for wrapping the material to be coated in sequence, wherein, in parts by weight, the isolation layer coating material includes: 2-8 parts of glue; 0.1-2 parts of hydroxypropyl methylcellulose or sodium carboxymethyl cellulose; 0.1-2 parts of magnesium stearate; glycerin, propylene glycol, polyethylene glycol, sorbitol, triethyl citrate 1-10 parts of one or more of esters, mannitol and isomalt; 40-180 parts of 75v / v%-85v / v% ethanol. The raw material cost of the coating material of the invention is low, the preparation method is simple, and the coated product can meet the use requirements of not disintegrating in simulated gastric juice for 2 hours and disintegrating in intestinal juice within 1 hour.

Description

technical field [0001] The invention belongs to the field of food technology, and in particular relates to an enteric coating material, a preparation method thereof and an enteric product containing the enteric coating material. Background technique [0002] At present, the common enteric coating materials are mainly shellac, cellulose acetate phthalate, alginate, polyvinyl alcohol acetate phthalate, acrylic resin, hydroxypropyl methylcellulose phthalate, etc. Among them, Most of them are only of pharmaceutical grade, limited to the enteric coating of drugs, and cannot be used for food coating, or there is a maximum usage limit when used as a food additive in food production, which cannot meet the needs of food production. [0003] At present, sodium alginate is used in enteric-coated hard capsules for many studies, and many patent applications are published. For example, Chinese patent application CN103877587A discloses a plant polysaccharide medicinal enteric-coated hard-s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23P20/10A23G3/54A61K9/36
CPCA23G3/54A61K9/286A61K9/2866A23P20/10A23P20/105
Inventor 徐杜渐王军德
Owner QINGDAO SHENGBANG HEALTH FOOD CO LTD
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