Flexible brain electrode with electrochemistry and electrophysiology detection functions and preparation method of flexible brain electrode

Abstract

The invention discloses a flexible brain electrode with electrochemistry and electrophysiology detection functions and a preparation method of the flexible brain electrode. The flexible brain electrode comprises a first electrode, a first silk protein layer, a metal wiring layer, a second silk protein layer, a second electrode and a third silk protein layer which are sequentially arranged, whereinthe first electrode is used for carrying out electrochemistry detection, the second electrode is used for carrying out electrophysiology detection, and the first electrode and the second electrode are respectively located on two opposite surfaces of the flexible brain electrode; and the metal wiring layer is located between the first electrode and the second electrode, the first silk protein layer is arranged between the metal wiring layer and the first electrode, the second silk protein layer is arranged between the metal wiring layer and the second electrode, and the third silk protein layer is located on the second silk protein layer. According to the flexible brain electrode, ''super-flexibility, high-resolution, high-integration-density and long-term in vivo'' nerve electrophysiology / neurotransmitter electrochemistry synchronous recording can be realized.

Description

technical field [0001] The invention relates to the technical field of brain function detection, in particular to a flexible brain electrode with electrochemical and electrophysiological detection functions and a preparation method thereof. Background technique [0002] Brain-computer interface is a multidisciplinary interdisciplinary technology involving neuroscience, signal detection and signal processing. It has important research significance and great application potential in the fields of biomedicine, neurorehabilitation and intelligent robots. It establishes a direct communication and control channel between the human brain and computers or other electronic devices, collects EEG signals from the cerebral cortex, and converts them into signals that can be recognized by the computer after amplification, filtering, and A / D conversion. The signal is preprocessed, the characteristic signal is extracted, and then these characteristics are used for pattern recognition, and f...

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Problems solved by technology

[0005] However, the implantable brain-computer interface in the prior art still has some deficiencies: 1) Most of the existing brain-computer interfaces have a single function, such as only measuring neurophysiological signals, but cannot measure the concentration of other important neurochemical substances. Synchronous real-time monitoring; 2) The electrochemical detection of non-electrically active neurotransmitters requires the use of enzymes (such as glutamate oxidase, acetylcholinesterase, etc.), which have problems such as instability and active degradation, and require complex immobilization protocol, which is an important factor limiting the in vivo time of neural electrode implantation for detecting electrochemical signals

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