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A kind of biodegradable crystal gel dressing and its preparation method and application

A biodegradable and crystal glue technology, applied in the field of biomedical materials, can solve the problems of unusable hemostatic materials, massive bleeding, and inability to press, and achieve excellent shape recovery performance, small inflammatory response, and good elasticity.

Active Publication Date: 2021-09-03
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to overcome the shortcomings of the above-mentioned prior art, the object of the present invention is to provide a biodegradable gel dressing and its preparation method and application, so as to solve the problem that existing hemostatic materials cannot be used for deep, narrow and non-compressible hemorrhage technical problems with fatal profuse bleeding

Method used

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  • A kind of biodegradable crystal gel dressing and its preparation method and application
  • A kind of biodegradable crystal gel dressing and its preparation method and application
  • A kind of biodegradable crystal gel dressing and its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0052] Preparation of GT25 / DA0 crystal gel dressing: adding gelatin (GT) to deionized water to configure a 5.0wt% GT solution; adding 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide Hydrochloride (EDC hydrochloride) was added to deionized water to configure a 75mg / mL EDC solution; N-hydroxysuccinimide (NHS) was added to deionized water to configure a 45mg / mL NHS solution; subsequently, Place the GT solution, EDC solution, NHS solution and deionized water in an ice-water mixing bath to fully pre-cool and then fully mix to obtain a final concentration of GT of 2.5wt%, wherein the amino groups on the gelatin, EDC and NHS and the molar The ratio was 1:0.5:0.5, and then the mixture was placed in a low-temperature reactor at -12°C for 36 hours. After the reaction, the crystal gel dressing was thawed, dialyzed in deionized water for 1 day, and freeze-dried at -80°C to obtain the biodegradable crystal gel dressing GT25 / DA0.

Embodiment 2

[0054] Preparation of GT25 / DA2 crystal gel dressing: adding gelatin to deionized water to configure 5.0wt% GT solution; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride Add to deionized water to make 75mg / mL EDC solution; add N-hydroxysuccinimide to deionized water to make 45mg / mL NHS solution; add dopamine hydrochloride to deionized water to make 100mg / mL DA solution; sodium periodate was added to deionized water to form a 37.6 mg / mL SP solution; subsequently, GT solution, EDC solution, NHS solution, DA solution, SP solution and deionized water were placed in an ice-water mixing bath Fully pre-cooled and then fully mixed to obtain a final concentration of GT of 2.5wt%, a final concentration of DA of 2.0mg / mL, wherein, the molar ratio of the amino group on the gelatin, EDC and NHS is 1:0.5:0.5, periodate The molar ratio of sodium to dopamine is 1:1. Then the mixture was placed in a low-temperature reactor at -12°C for 36 hours of reaction. After the reaction, the ...

Embodiment 3

[0056] The final concentration of DA in Example 2 is controlled at 4.0mg / mL, 6.0mg / mL, 8.0mg / mL and 10.0mg / mL respectively, and other conditions are the same as in Example 2, and the biodegradable gel dressing GT25 can be obtained respectively / DA4, GT25 / DA6, GT25 / DA8 and GT25 / DA10.

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Abstract

The invention discloses a biodegradable crystal gel dressing and its preparation method and application, which belong to the technical field of biomedical materials. Amino compounds are selected as the main components. The selected amino compounds have good biocompatibility and can degrades in living organisms. Therefore, the amidation reaction between the amino group and the carboxyl group in the amino compound is catalyzed by EDC hydrochloride and NHS to form the basic network structure of the crystal gel. The crystal gel dressing has interconnected pores in the free state. Compared with the shape free state, the crystal gel dressing shows collapsed and closed pores in the shape-fixed state, but the crystal gel dressing sample still maintains an unbroken network structure. The preparation method of the present invention is simple, low in cost, easy to carry, and biodegradable. The prepared crystal gel dressing can quickly stop bleeding, and has great potential as a new hemostatic agent for promoting wound healing.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to a biodegradable crystal gel dressing and a preparation method and application thereof. Background technique [0002] The occurrence of wars, traffic accidents and natural disasters can easily lead to bleeding in the human body. It has been reported that more than 30% of traumatic deaths worldwide are due to excessive blood loss. Therefore, hemostatic agents with rapid hemostasis are essential for the treatment of severe traumatic bleeding. Although existing hemostatic materials such as cyanoacrylates, glutaraldehyde-crosslinked albumin, zeolite-based QuickClot, or fibrin-based bandages have high hemostatic efficiencies, they often fail to stop deep or narrow wounds , Incompressible bleeding. In particular, surgical sutures are the only clinically available wound closure to stop aortic hemorrhage, which is difficult to apply in emergency situations. [0003] Further...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L26/00A61K38/14A61K31/65A61K31/137A61K41/00A61K9/06A61P7/04A61P17/02A61P31/02A61P31/04A61P39/06C08J3/24C08J9/28
CPCA61K9/0019A61K9/06A61K31/137A61K31/65A61K38/14A61K41/0052A61L26/0004A61L26/0023A61L26/0038A61L26/0061A61L26/0066A61L26/008A61L26/0085A61L26/009A61L2300/404A61L2300/406A61L2300/412A61L2300/418A61L2300/602A61L2400/04A61L2400/06A61P7/04A61P17/02A61P31/02A61P31/04A61P39/06C08J3/246C08J9/28C08J2389/00C08L5/08C08L5/04A61K2300/00
Inventor 郭保林黄颖赵鑫
Owner XI AN JIAOTONG UNIV
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