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Application of thymosin or derivative thereof and medicine for treating depression

A technology of thymosin and derivatives, applied in the field of pharmacy, can solve the problems of death, acute poisoning, difficulty and so on

Active Publication Date: 2020-10-27
SHENZHEN INST OF GUANGDONG OCEAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the drugs used to treat depression are mainly monoamine reuptake inhibitors, such as bupropion, duloxetine, fluoxetine, etc., but these drugs can cause tachycardia, drowsiness, and constipation , dysuria, urinary retention and other serious cardiovascular side effects, and overdose can cause acute poisoning or even death

Method used

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  • Application of thymosin or derivative thereof and medicine for treating depression
  • Application of thymosin or derivative thereof and medicine for treating depression
  • Application of thymosin or derivative thereof and medicine for treating depression

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Experimental program
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Effect test

Embodiment

[0025] 1. Experimental animals

[0026]Sexually mature female C57BL / 6 mice, body weight (20-22 g), were purchased from Shandong Experimental Animal Center (animal quality certificate: No. 37009200018914, license number: SCXK (Lu) 2014000). Breeding environment: 4 mice per cage, 22±1°C temperature, 50±10% humidity, 12h light-dark cycle, free to eat and drink. The feeding and operation of experimental animals complied with the relevant regulations on the feeding and use of experimental animals of Guangdong Ocean University.

[0027] Thymosin β4: purchased from Guangzhou Binshang Biotechnology Co., Ltd.

[0028] Rats and mice maintained powder feed: provided by Guangdong Experimental Animal Center.

[0029] Behavioral instruments: Shanghai Xinruan Information Technology Co., Ltd.

[0030] 2. Experimental plan

[0031] After the animals were repurchased and adapted to the laboratory for one week, they were randomly numbered and grouped into 3 groups, as shown in Table 1:

[0...

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Abstract

The invention belongs to the field of pharmacology, discloses an application of thymosin or a derivative thereof and a medicine for treating depression, and particularly discloses an application of the thymosin or the derivative thereof in preparation of the medicine for treating the depression. The invention also discloses a pharmaceutical composition for treating the depression, and the pharmaceutical composition comprises a treatment effective dose of the thymosin or the derivative thereof. In the technical scheme of the invention, the systemic administration of the thymosin or the derivative thereof, especially thymosin [beta]4 or a derivative thereof, is safe, and the thymosin or the derivative thereof has a good curative effect on the depression and is tolerated by animals includinghuman beings.

Description

technical field [0001] The application relates to the field of pharmacology, specifically, the application of thymosin and its derivatives and the medicine for treating depression. Background technique [0002] Depression is a common mental illness with main symptoms: low mood, loss of interest in things, anhedonia; hopelessness and helplessness; anxiety; sleep and appetite disorders; memory loss and poor learning ability; severe cases may even commit suicide tendencies or behaviors. The core symptoms are anhedonia and helpless behavior. According to data from the World Health Organization, the number of depression patients worldwide exceeds 340 million, and the number of depression patients in China is nearly 100 million, and the incidence rate is significantly higher than that in foreign countries. Depression is expected to become the second leading disease worldwide by 2020. Although medicine has certain treatment measures for depression, due to the complex pathologica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/22A61P25/24
CPCA61K38/2292A61P25/24
Inventor 宋采张才李晓红张永平张翼
Owner SHENZHEN INST OF GUANGDONG OCEAN UNIV
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