Weeding composition containing trifluoromethyl pyridazinol compound, and application of weeding composition
A technology of trifluoromethylpyridazinol and herbicidal composition, which is applied in the field of pesticides and can solve the problems of reducing the amount of application and expanding the herbicidal spectrum
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[1031] (1) Preparation of intermediates
[1032]
[1033] (1.1) Dissolve compound C-1 in dioxane solution, add sodium methoxide solution (30% content, 1.5eq) and raise the temperature to 100 degrees to react for 16-18 hours, and monitor the completion of the reaction through liquid phase. Cool the reaction solution to room temperature, remove the solvent with concentrated acid, dissolve it with 1M hydrochloric acid solution, extract with ethyl acetate until the aqueous phase has no product, concentrate the organic phase to obtain a solid, petroleum ether: ethyl acetate = 10:1, beat and purify , and filtered to obtain product C-2.
[1034] (1.2) Dissolve compound C-2 in DCE, add phosphorus oxychloride (3eq) and DMF (2%), and react at 100°C for 16-18 hours. Liquid phase monitoring After the reaction is completed, the reaction solution is cooled and concentrated, and the obtained product is added to water under temperature control. A large amount of solids will precipitate ou...
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