Medicine for treating degenerative arthritis and preparation method thereof

A degenerative arthritis and drug technology, applied in the field of drugs for the treatment of degenerative arthritis and their preparation, can solve problems such as restricting the application of glucocorticoids, accelerating joint degeneration, articular cartilage damage, etc., improving histological scores, reducing The effect of burst release and uniform particle size distribution

Pending Publication Date: 2020-10-23
SHANDONG GUYUCHUN BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Glucocorticoids are the preferred drug for intra-articular injection recommended by the 2018 edition of the "Guidelines for the Diagnosis and Treatment of Osteoarthritis". It quickly disappears in the joint space, which greatly limits the clinical application of glucocorticoids

Method used

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  • Medicine for treating degenerative arthritis and preparation method thereof
  • Medicine for treating degenerative arthritis and preparation method thereof
  • Medicine for treating degenerative arthritis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Weigh 85 g of lactide monomer and 15 g of glycolide monomer, add 47 mg of stannous chloride as a catalyst, and 0.5 g of anhydrous ethanol as a blocking agent. React at 175°C for 24 hours. After the reaction is complete, add dichloromethane to dissolve. Anhydrous methanol was used for precipitation, the supernatant was discarded, and a white viscous product was obtained by repeating 3 times, which was dried in vacuum at 50°C to constant weight to obtain linear PLGA (85:15) with a molecular weight Mw of 48821.

Embodiment 2

[0025] Weigh 75 g of lactide monomer and 25 g of glycolide monomer, add 56 mg of stannous chloride as a catalyst, and 0.5 g of cyclohexanol as a blocking agent. React at 170°C for 24 hours. After the reaction is complete, add dichloromethane to dissolve , Precipitation with anhydrous methanol, discarding the supernatant, repeated 3 times to obtain a white viscous product, and vacuum drying at 50°C to a constant weight to obtain a six-arm PLGA (75:25) with a molecular weight Mw of 43526.

Embodiment 3

[0027] Weigh 85 g of lactide monomer and 15 g of glycolide monomer, add 41 mg of stannous chloride as a catalyst, and 0.5 g of cyclohexanol as a blocking agent. React at 175°C for 24 hours. After the reaction is complete, add dichloromethane to dissolve , Precipitation with anhydrous methanol, discarding the supernatant, repeating 3 times to obtain a white viscous product, and vacuum drying at 50°C to constant weight to obtain a six-arm PLGA (85:15) with a molecular weight Mw of 42290.

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Abstract

The invention belongs to the technical field of medicine preparation, and particularly relates to a medicine for treating degenerative arthritis and a preparation method thereof. The medicine is a micro-capsule formed by wrapping a glucocorticoid medicine with a biodegradable material; and the mass ratio of the biodegradable material to the glucocorticoid medicine is (4-2): (1-3). The biodegradable material is six-armed polylactide-glycolide, and the glucocorticoid medicine is triamcinolone acetonide. The medicine obtained by adopting the method can better control burst release of a combined medicine, the drug loading capacity is improved, and the effective components can be stably and slowly released.

Description

Technical field [0001] The invention belongs to the technical field of medicine preparation, and specifically relates to a medicine for treating degenerative arthritis and a preparation method thereof. Background technique [0002] With the increase of age and the loss of calcium, human bones slowly appear degenerative diseases. Among them, the first degenerative diseases appear, usually the waist and knees. Osteoarthritis is an arthritis disease characterized by cartilage destruction and caused by mechanical, metabolic, inflammatory, and immune factors. It occurs in weight-bearing parts of the human body, such as knee joints, hip joints, and spine, among which knee joints are most likely to occur. Glucocorticoids are the first choice for intra-articular injection in the 2018 edition of the "Guidelines for the Diagnosis and Treatment of Osteoarthritis". However, due to the high local drug concentration in the joint cavity, potential damage to articular cartilage, accelerated joi...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K31/58A61K9/50A61K47/34A61P19/02A61P29/00C08G63/08
CPCA61K45/06A61K31/58A61K9/5031A61K9/5089A61P19/02A61P29/00C08G63/08
Inventor 苏红清李建袁文博褚吉阳
Owner SHANDONG GUYUCHUN BIOTECHNOLOGY CO LTD
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