Method for constructing oral implant high-occlusion animal model
A technology for oral implants and animal models, which is applied in the fields of treatment of animal teeth, medical science, veterinary instruments, etc., can solve the problems of insufficient sample size, high price, poor repeatability, etc., and achieves low drug cost and repeatability. High, high success rate effect
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[0030] Embodiment 1: Model construction method and model verification of the present invention
[0031] 1. Animal preparation
[0032] In the present invention, 30 5-week-old BALB / C mice were selected, and all animal experiments were supported by the Stanford Animal Research Ethics Committee, free to eat and drink, and the rhythm of life followed the circadian rhythm.
[0033] 2. Surgery and model building process
[0034] 2.1 tooth extraction
[0035] The reason why the present invention chooses 5 weeks as the tooth extraction time is that after the age of the mice exceeds this time, the cementum gradually accumulates in the apical area, which increases the difficulty of tooth root extraction and is prone to root fracture. After intraperitoneal anesthesia of 5-week-old mice, the bilateral maxillary first molars (mxM1) were extracted using fine toothed forceps. The whole operation needs to be completed within 3-5 minutes, and the bleeding can be stopped by local compression...
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