Controllable preparation method of modified hydroxyapatite powder based on microfluidic control and hydroxyapatite nano particles

A hydroxyapatite and nanoparticle technology, applied in nanotechnology, nanotechnology, nanotechnology and other directions for materials and surface science, can solve problems such as reducing skin feel effect, poor dispersibility, etc., and achieve rich sources and particle size. Small, highly biocompatible effect

Active Publication Date: 2020-09-25
HUNAN YUJIA COSMETICS MFG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In contrast, the existing cosmetic hydroxyapatite powders on the market have a particle size of micron or hundreds of nanometers, and poor dispersion, which reduces the skin feel and efficacy as an active substance in skin care products.

Method used

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  • Controllable preparation method of modified hydroxyapatite powder based on microfluidic control and hydroxyapatite nano particles
  • Controllable preparation method of modified hydroxyapatite powder based on microfluidic control and hydroxyapatite nano particles
  • Controllable preparation method of modified hydroxyapatite powder based on microfluidic control and hydroxyapatite nano particles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Preparation of Nanometer Hydroxyapatite Nuclei

[0041] First prepare CaCl with a concentration of 0.01M 2 aqueous solution, adding a sodium polyacrylate aqueous solution with a molecular weight of 30,000 Da, and stirring and mixing the two for 6 hours. At the same time, the preparation concentration of 0.006M (NH 4 ) 2 HPO 4 aqueous solution, and adjust the pH to 10 with ammonia water. Three groups of parallel experiments were done, and the added sodium polyacrylate aqueous solution was 0-4 mg / mL.

[0042] refer to figure 1 As shown, the oil phase solution is configured as the continuous phase of the microfluidic system, and the oil phase is composed of mineral oil, oleic acid and Span-80, and the ratio is 98:1:1. Place phase A and phase B of the calcium and phosphorus precursor solution in the two water phase channels of the microfluidic system, place C phase mineral oil in the oil phase channel, and simultaneously use air pressure to squeeze the two phases A an...

Embodiment 2

[0052] Preparation of Nanometer Hydroxyapatite Nuclei

[0053] First prepare CaCl at a concentration of 0.01M to 0.04M 2 aqueous solution, adding a sodium polyacrylate aqueous solution with a molecular weight of 30,000 Da and a final concentration of 4 mg / mL, and stirring and mixing the two for 6 hours. At the same time, the preparation concentration of 0.006M (NH 4 ) 2 HPO 4 aqueous solution, and adjust the pH to 10 with ammonia water. The oil phase solution was configured as the continuous phase of the microfluidic system, and the oil phase was composed of mineral oil, oleic acid and Span-80 at a ratio of 98:1:1. Place A and B phases of calcium and phosphorus precursors in the two water phase channels of the microfluidic system, and place C phase mineral oil in the oil phase channel. At the same time, the two phases A and B are extruded into the reaction system by air pressure, and the primary crystal nucleus of calcium phosphate is formed at the intersection of the two...

Embodiment 3

[0056] Preparation of nano-hydroxyapatite

[0057] First prepare CaCl with a concentration of 0.01M 2 aqueous solution, adding a sodium polyacrylate aqueous solution with a molecular weight of 30,000 Da and a final concentration of 4 mg / mL, and stirring and mixing the two for 6 h. At the same time, the preparation concentration of 0.006M (NH 4 ) 2 HPO 4 aqueous solution, and adjust the pH to 10 with ammonia water. Aqueous solution of sodium polyacrylate was added.

[0058] The oil phase solution was configured as the continuous phase of the microfluidic system, and the oil phase was composed of mineral oil, oleic acid and Span-80 at a ratio of 98:1:1. Place A and B phases of calcium and phosphorus precursors in the two water phase channels of the microfluidic system, and place C phase mineral oil in the oil phase channel. At the same time, the two phases A and B are extruded into the reaction system by air pressure, and the primary crystal nucleus of calcium phosphate is...

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Abstract

The invention discloses a controllable preparation method of modified hydroxyapatite powder based on microfluidic control. A micro-channel chip with a Y-shaped structure is used as a reaction container; mineral oil / oleic acid / Span-80 is used as an oil phase containing an emulsifier; an inorganic calcium ion / sodium polyacrylate aqueous solution and an ammonia water / phosphate ion aqueous solution are used as aqueous phases, calcium phosphate crystal nucleuses are formed in the micro-flow droplets and further grow to spherical / shuttle-shaped hydroxyapatite nano particles, the obtained hydroxyapatite nano particles are controllable in particle size, and the particle size of the hydroxyapatite nano particles ranges from 3 nm to 80 nm. The prepared hydroxyapatite nano particles have high dispersity and good biocompatibility, and can be applied to multiple fields of cosmetic sun-screening agents, abrasives, concealer, and the like.

Description

【Technical field】 [0001] The invention relates to the technical field of inorganic material preparation technology, in particular to a controllable preparation method of modified hydroxyapatite powder based on microfluidics and hydroxyapatite nanoparticles. 【Background technique】 [0002] Hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 , Hydroxyapatite, HAP) is the main inorganic component in human hard tissue. This ingredient has good biocompatibility to the human body, and has the advantages of no immunogenicity, no tumorigenicity, and no teratogenicity. It is first widely used in the field of hard tissue repair, such as dental implant coating, bone repair, etc. bracket etc. When hydroxyapatite reaches the nanoscale, it has excellent biodegradability. The degradation products are phosphate and calcium ions, both of which are inorganic salts required by the human body. In particular, calcium ions have a stimulating and repairing effect on skin tissue. At the same time, recent...

Claims

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Application Information

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IPC IPC(8): C01B25/32B82Y30/00B82Y40/00
CPCC01B25/325B82Y30/00B82Y40/00C01P2004/02C01P2004/04C01P2002/72C01P2004/64
Inventor 戴跃锋何广文颜少慰马晓瑜
Owner HUNAN YUJIA COSMETICS MFG CO LTD
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