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Method and device for facilitating biomolecular sensing and biomolecular sensing system

A molecular sensing and biomolecular technology, applied in the analysis of materials, the use of sonic/ultrasonic/infrasonic waves to analyze fluids, instruments, etc. The detection of trace biomolecules and other problems can improve the detection sensitivity and detection speed, shorten the transportation time, and reduce the detection limit.

Active Publication Date: 2020-09-22
TIANJIN UNIV
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Problems solved by technology

For example, in actual detection, the performance of the sensor is limited by the diffusion of biomolecules at the solid-liquid interface, so the sensor faces practical problems such as low molecular adsorption efficiency, slow detection speed, and difficulty in detecting trace biomolecules in complex samples; Heterotropic adsorption will generate strong background noise, which will affect the detection limit, sensitivity, selectivity and device repeatability of target protein detection or generate false positive signals
[0004] Existing enhanced sensing methods, such as optical, electrical and other physical field-driven fluid methods, have the characteristics of poor biocompatibility, complex equipment, and strict requirements on the chargeability of biomolecules or solution transparency, so these methods lack reliability. controllability, versatility and efficiency

Method used

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  • Method and device for facilitating biomolecular sensing and biomolecular sensing system
  • Method and device for facilitating biomolecular sensing and biomolecular sensing system
  • Method and device for facilitating biomolecular sensing and biomolecular sensing system

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Embodiment Construction

[0041] In the following description, references to "some embodiments" describe a subset of all possible embodiments, but it is understood that "some embodiments" may be the same subset or a different subset of all possible embodiments, and Can be combined with each other without conflict.

[0042] In the following description, the terms "first\second\third, etc." or module A, module B, module C, etc. are only used to distinguish similar objects, and do not represent a specific ordering of objects. It is understandable Obviously, where permitted, the specific order or sequence can be interchanged such that the embodiments of the application described herein can be practiced in other sequences than those illustrated or described herein.

[0043] In the following description, the involved reference numerals representing steps, such as S110, S120, etc., do not mean that this step must be executed, and the order of the previous and subsequent steps can be interchanged or executed s...

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Abstract

A method of facilitating biomolecular sensing includes: driving a resonator to generate a gigahertz (GHz) level acoustic fluid in a liquid; and driving biomolecules in a flow field to be transported to a sensing interface of a biosensor in the acoustic fluid action area through the GHz-level acoustic fluid. Also provided is a device for facilitating biomolecular sensing, comprising: an acoustic fluid system portion comprising a resonator for generating an acoustic fluid of GHz level; a cylindrical cavity, positioned in the acoustic fluid action area of the resonator and used for limiting the range of an acoustic fluid field and accommodating a sensing interface of the biomolecular sensor. Correspondingly, the invention also provides a biomolecular sensing system. By using the sensor, the biomolecular sensing function of the sensor can be promoted.

Description

technical field [0001] The present application relates to the technical field of biomolecular detection, in particular to a method and device for promoting biomolecular sensing and a biomolecular sensing system. Background technique [0002] Biomolecular detection, such as tumor markers, specific DNA sequence and other molecular detection, plays an important role in the research of cell function, early detection and clinical application of cancer and other diseases, molecular drug development and other fields. [0003] Although great development and progress have been made in the research field, the practical application of biosensors has been slow. Among them, the practical requirements of enhancing molecular adsorption and reducing non-specific adsorption make the applicability of sensors face great challenges. For example, in actual detection, the performance of the sensor is limited by the diffusion of biomolecules at the solid-liquid interface, so the sensor faces prac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N29/02
CPCG01N29/02G01N2291/02416G01N2291/02466
Inventor 段学欣潘书婷庞慰
Owner TIANJIN UNIV
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