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Eucommia ulmoides extract and application thereof in treatment of osteoporosis

An extract and Eucommia bark technology, applied in the field of traditional Chinese medicine extraction, can solve the problems such as difficult control of active ingredient content, complex medicinal effect ingredient content, etc., and achieve the effects of simple and easy extraction and separation method, easy operation, and simple extraction method.

Inactive Publication Date: 2020-09-22
JIANGXI POZIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The composition has a good effect on treating osteoporosis, but the content of the active ingredients in the mixed extract is relatively complicated, and it is not easy to control the contents of various active ingredients

Method used

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  • Eucommia ulmoides extract and application thereof in treatment of osteoporosis
  • Eucommia ulmoides extract and application thereof in treatment of osteoporosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-4

[0041] Embodiment 1-4 A kind of Eucommia extract

[0042] Example Eucommia Petroleum Ether Extract Eucommia Ethanol Extract Example 1 20 copies 10 copies Example 2 50 copies 30 copies Example 3 50 copies 10 copies Example 4 30 copies 30 copies

[0043] Preparation:

[0044] The preparation method of described eucommia petroleum ether extract is:

[0045] (1), firstly, the bark of Eucommia ulmoides, the leaves of Eucommia ulmoides or the whole plant of Eucommia ulmoides are cleaned, and after drying, they are ultrasonically soaked in 8 times the volume of 60% petroleum ether for 24 hours, filtered, and the filtrate A1 and filter residue a1 are collected;

[0046] (2) Add 5 times the volume of 60% petroleum ether to the filter residue a1 obtained in step (1) and carry out reflux extraction for 10 hours at 80° C.; filter, collect the filtrate A2, and discard the filter residue a2;

[0047] (3) The filtrate A1 in the step (1) ...

Embodiment 5-8

[0052] Example 5-8 A kind of Eucommia extract

[0053] Example Eucommia Petroleum Ether Extract Eucommia Ethanol Extract Example 5 30 copies 10 copies Example 6 39 copies 13 copies Example 7 45 copies 15 copies Example 8 48 copies 16 copies

[0054] Preparation:

[0055] The preparation method of described eucommia petroleum ether extract is:

[0056] (1), firstly wash the bark of Eucommia ulmoides, the leaves of Eucommia ulmoides or the whole plant of Eucommia ulmoides;

[0057] (2) Add 6 times the volume of 80% petroleum ether to the filter residue a1 obtained in step (1) and carry out reflux extraction for 10 hours at 75° C.; filter, collect the filtrate A2, and discard the filter residue a2;

[0058] (3) The filtrate A1 in the step (1) and the filtrate A2 in the step (2) are combined and subjected to vacuum distillation to obtain the Eucommia petroleum ether extract.

[0059] The preparation method of the Eucommia ethan...

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Abstract

The invention provides eucommia ulmoides extract and an application thereof in treatment of osteoporosis, and belongs to the technical field of traditional Chinese medicine extraction. The eucommia ulmoides extract comprises the following components in parts by weight: 20-50 parts of eucommia ulmoides petroleum ether extract and 10-30 parts of eucommia ulmoides ethanol extract; the eucommia ulmoides extract can be effectively used for treating the osteoporosis by controlling the weight part ratio of the eucommia ulmoides petroleum ether extract to the eucommia ulmoides ethanol extract to be (1-5): 1. The invention further provides an extraction method of the eucommia ulmoides petroleum ether extract and the eucommia ulmoides ethanol extract. Due to the fact that different effective components are different in solubility in different solvents, the content of the effective components can be effectively adjusted by adopting different solvents for extraction; the used extraction separationmethod is simple and easy to implement; and the osteoporosis treating effect is good.

Description

technical field [0001] The invention belongs to the technical field of extracting traditional Chinese medicines, and in particular relates to an extract of Eucommia ulmoides and its application in treating osteoporosis. Background technique [0002] Osteoporosis is a systemic and systemic skeletal disease characterized by decreased bone mass and microstructural destruction of bone tissue, leading to increased bone fragility and increased fracture risk. Its clinical symptoms are mostly bone pain and fractures. For chronic diseases caused by multiple factors, the treatment cycle is relatively long. Although currently clinically used drugs for the treatment of osteoporosis, such as calcitonin, bisphosphonates, parathyroid hormone, estrogen, selective estrogen receptor modulators, etc., have achieved good curative effect, However, long-term medication will have negative effects. It has been found that the existing drugs can only thicken the thinned bone trabeculae, but cannot r...

Claims

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Application Information

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IPC IPC(8): A61K36/46A61P19/10A23L33/105A61K129/00A61K127/00
CPCA23V2002/00A61K36/46A61K2236/333A61K2236/35A61K2236/39A23L33/105A61P19/10A23V2200/306A23V2200/30A23V2250/21
Inventor 陈梁李小锋夏淑英胡吉忠毛金娣张金良周朝忠
Owner JIANGXI POZIN PHARMA
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