A kind of preparation method of cyromazine

Abstract

The invention discloses a preparation method of cyromazine, which uses melamine as a starting material and undergoes acidic hydrolysis to obtain 4,6-diamino-2-hydroxyl-1,3,5-triazine, 4,6 ‑Diamino‑2‑hydroxy‑1,3,5‑triazine is chlorinated to obtain the toluene solution of 4,6‑diamino‑2‑chloro‑1,3,5‑triazine, 4,6‑diamino ‑2‑Chloro‑1,3,5‑triazine undergoes amination reaction with cypromine to form cyromazine. The present invention avoids the generation of toxic 2-cyclopropylamino-4,6-dichloro-S-triazine, avoids the use of ammoniation pressurized equipment, has milder reaction conditions, and uses cheaper materials to prepare cyclo Alamazine, high yield, good quality.

Description

technical field [0001] The invention belongs to the technical field of organic chemical synthesis, and in particular relates to a preparation method of cyromazine, a veterinary drug and a pharmaceutical raw material drug. Background technique [0002] Cyromazine, chemically called 2-cyclopropylamino-4,6-diamino-1,3,5-triazine, also known as cyromazine, was first developed by Ciba-Geigy Corporation, FDA (U.S. Food and Drug Administration) Drug Administration) and EPA (U.S. Environmental Protection Association) officially approved the production of new pesticides in 1974. In recent years, the drug has been widely used in animal husbandry, and the effect is remarkable. [0003] According to literature reports, the traditional synthesis process of cyromazine has many steps and takes a long time. It is generally divided into three steps, and the second and third step reaction times are relatively long, requiring a total of 36 to 48 hours, and the product yield is low. In the pat...

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Problems solved by technology

However, there is an intermediate in these preparation methods, i.e. 2-cyclopropylamino-4,6-dichloro-S-triazine, which has the disadvantages of high toxicity and easy sensitization, which is not conducive to safe production and environmental protection

There are also researchers who use xylene as the reaction solvent to isolate the reaction materials from the environment, and add ethanol in the ammoniation step to shorten the reaction time. Although the yield is increased to 88%, there are also 2-cyclopropylamino-4,6 -The safety hazard of dichloro-S-triazine, similarly, in the final product formation step, use autoclave and ammonia gas, carry out the ammoniation reaction under high temperature 105~135 ℃, pressurization 1.2~1.7Mpa, cause production process there is a certain risk in

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