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Detection method and kit for polymorphism of 7q36.3 region related to occurrence of noise induced hearing loss and application thereof

A kit and noise technology, applied in biochemical equipment and methods, microbial determination/examination, DNA/RNA fragments, etc., can solve problems such as insufficient interpretation of NIHL total heritability, limited GWAS sample size, etc.

Active Publication Date: 2020-08-28
THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these findings are insufficient to explain the total heritability of NIHL
[0003] In addition, the existing NIHL GWAS sample size is limited, and a genome-wide association study of NIHL has never been conducted in the Chinese population

Method used

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  • Detection method and kit for polymorphism of 7q36.3 region related to occurrence of noise induced hearing loss and application thereof
  • Detection method and kit for polymorphism of 7q36.3 region related to occurrence of noise induced hearing loss and application thereof
  • Detection method and kit for polymorphism of 7q36.3 region related to occurrence of noise induced hearing loss and application thereof

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Experimental program
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Embodiment

[0048] 1. Materials and methods

[0049] 1.1 Genome-wide association study samples

[0050]In this study, the inventors carried out a genome-wide association study (Genome-wide association study, GWAS) in two Chinese populations. The study included two phases, with a total of 711 Chinese men. Specifically, the discovery phase included 298 subjects, and the validation phase included 413 subjects (see Table 1). Pure tone audiometry was performed on each subject to detect the smallest sound heard by the subject's ear at high frequency and speech frequency respectively. According to the classification of the World Health Organization, if the minimum hearing threshold of either side of the subject's ears is greater than 25 decibels, the subject can be regarded as a case of noise-induced hearing loss. According to this criterion, the excavation phase included 89 cases and 209 controls. While the validation phase contained 53 cases and 360 controls (see Table 1). In addition, the...

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Abstract

The invention relates to a method and kit for detecting an SNP (Single Nucleotide Polymorphism) site rs10081191 of a susceptible gene region 7q36.3 related to a disease risk of NIHL (Noise Induced Hearing Loss), and application. The method is Sequenom typing. The invention further relates to the kit for detecting the susceptible site and application of the kit. In addition, the SNP site rs10081191of the region 7q36.3 is associated with the disease risk of the NIHL, and the invention discloses the SNP and application thereof. The SNP is located in a human genome region 7q36.3, the 7q36.3 is determined to be a new susceptible gene region of the NIHL, and the SNP can be effectively used for screening susceptible groups of the noise induced hearing loss diseases and determining susceptible individuals of the noise induced hearing loss diseases.

Description

technical field [0001] The present invention relates to the field of biotechnology. Specifically, the present invention relates to the polymorphism detection method, kit and application of the 7q36.3 region associated with the occurrence of noise-induced hearing loss, and more specifically, the present invention relates to SNP markers related to noise-induced hearing loss. The primer set and kit for detecting the aforementioned SNP markers, the use of the aforementioned SNP markers, primer sets, and kits in determining susceptible individuals for noise-induced hearing loss diseases, and the method for determining susceptible individuals for noise-induced hearing loss diseases. Background technique [0002] Noise is one of the most common environmental pollution in the living environment. Regular exposure to noise can lead to noise-induced hearing loss (NIHL). With millions of people exposed to harmful levels of noise every day, approximately 5% of the world's population su...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883C12N15/11
CPCC12Q1/6883C12Q2600/156
Inventor 牛玉光周钢桥李佳楠于慧颖李元丰谢成勇
Owner THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL
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