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Polypyrrole/manganese dioxide-methylene blue nanocomposite particles and preparation method thereof

A nano-composite particle, manganese dioxide technology, applied in the direction of wave energy or particle radiation treatment materials, pharmaceutical formulations, drug combinations, etc., to achieve the effect of strong operability, improvement ability, and improvement of tumor hypoxic environment

Active Publication Date: 2021-09-28
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, a polypyrrole / manganese dioxide nanocomposite particle is obtained by in-situ oxidation-reduction reaction with potassium permanganate as the inner core and reducing agent for a few minutes at room temperature, and the photosensitizer methylene blue is loaded to obtain polypyrrole / manganese dioxide nanocomposite particles Pyrrole / manganese dioxide-methylene blue nanocomposite particles used as photothermal and photodynamic combined therapy materials have never been reported

Method used

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  • Polypyrrole/manganese dioxide-methylene blue nanocomposite particles and preparation method thereof
  • Polypyrrole/manganese dioxide-methylene blue nanocomposite particles and preparation method thereof
  • Polypyrrole/manganese dioxide-methylene blue nanocomposite particles and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0044] Preparation and characterization of polypyrrole / manganese dioxide-methylene blue nanocomposite particles:

[0045] (1) Dissolve 1.5g of polyvinyl alcohol 13000-23000 in 18mL of secondary water and stir at 80°C for 40 minutes; after the solution cools down to room temperature, add 1.25g of FeCl 3 ·6H 2 O, and stirred for 1 hour; then 135 μL of pyrrole monomer was added and stirred at 4°C for 4 hours; after the reaction, centrifuged and washed 5 times with hot secondary water to obtain polypyrrole nanoparticles, which were freeze-dried for later use.

[0046] figure 1 In order to use a transmission electron microscope to characterize the morphology of the obtained polypyrrole nanoparticles, the scale bar is 200 nm. The results show that the obtained polypyrrole nanomaterials are spherical, with good dispersion and an average size of 68.18nm.

[0047] figure 2 For the result of characterizing the obtained polypyrrole nanoparticles by X-ray photoelectron spectrometer, ...

Embodiment 2

[0057] Preparation and characterization of polypyrrole / manganese dioxide-methylene blue nanocomposite particles:

[0058] (1) Dissolve 1.6g of polyvinyl alcohol 13000-23000 in 20mL of secondary water, stir at 75°C for 50 minutes; after the solution cools down to room temperature, add 1.3g of FeCl 3 ·6H 2 O, and stirred for 1.5 hours; then added 140 μL of pyrrole monomer, and stirred for 4.5 hours at 3° C.; after the reaction, centrifuged and washed 4 times with hot secondary water to obtain polypyrrole nanoparticles, which were freeze-dried for later use;

[0059] (2) Disperse 20 mg of polypyrrole nanoparticles prepared in step (1) in 8 mL of secondary water by ultrasonic dispersion, and set aside; dissolve 12.5 mg of potassium permanganate in 12 mL of secondary water, and add dropwise to the dispersed Stirring in the polypyrrole nanoparticles, reacting for 15 minutes, washing with secondary water and absolute ethanol three times alternately, and drying to obtain polypyrrole / ...

Embodiment 3

[0063] Preparation and characterization of polypyrrole / manganese dioxide-methylene blue nanocomposite particles:

[0064] (1) Dissolve 1.55g of polyvinyl alcohol 13000-23000 in 19mL of secondary water and stir at 70°C for 45 minutes; after the solution has cooled to room temperature, add 1.2g of FeCl 3 ·6H 2 O, and stirred for 1 hour; then added 138 μL of pyrrole monomer, and stirred for 3.5 hours at 5° C.; after the reaction, centrifuged, and washed with hot secondary water for 3 times to obtain polypyrrole nanoparticles, freeze-dried for later use;

[0065] (2) Disperse 17 mg of polypyrrole nanoparticles prepared in step (1) in 8 mL of secondary water by ultrasonic dispersion and set aside; dissolve 5 mg of potassium permanganate in 12 mL of secondary water and add dropwise to the dispersed polypyrrole nanoparticles. Stirring in the pyrrole nanoparticles, reacting for 5 minutes, washing with secondary water and absolute ethanol four times alternately, and drying to obtain p...

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Abstract

The invention discloses a polypyrrole / manganese dioxide-methylene blue nanocomposite particle and a preparation method thereof, belonging to the technical field of nanocomposite materials. In the present invention, the polypyrrole / manganese dioxide nanocomposite particles are directly prepared by in-situ redox reaction between the polypyrrole inner core and potassium permanganate, and after the photosensitizer methylene blue is loaded, the polypyrrole / manganese dioxide-methylene blue nanocomposite is finally obtained. Particles with a particle size of 69‑72nm. The nanocomposite particles have good photothermal conversion ability and singlet oxygen generation performance, and have good killing ability to cancer cells under laser radiation, indicating that they can be used as effective photothermal and photodynamic combined therapy materials. The invention prepares the polypyrrole / manganese dioxide nano-composite particles by directly mixing the polypyrrole nano-particles with potassium permanganate, and rapidly reacts to prepare the polypyrrole / manganese dioxide nano-composite particles. The process does not require additional reducing agent, avoids the use of large-scale instruments, and is simple and easy to operate. Fast response, green and environmentally friendly.

Description

technical field [0001] The invention relates to a nanocomposite material, in particular to a polypyrrole / manganese dioxide-methylene blue nanocomposite particle and a preparation method and application thereof. Background technique [0002] Currently, cancer remains one of the deadliest diseases, killing millions of people every year. The development of nanomedicine can improve cancer treatment indicators and reduce side effects, opening up a new way for cancer treatment. Chemotherapy and radiation therapy are still the two most important clinical treatment methods at present, but both of them are prone to cause severe systemic toxicity and adverse reactions. In contrast, photothermal therapy and photodynamic therapy have attracted attention because of their specific spatiotemporal selectivity, less trauma, less side effects, negligible drug resistance, and faster healing. [0003] Various nanomaterials have been used in photothermal therapy, such as gold nanomaterials, co...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K9/14A61P35/00
CPCA61K9/14A61K41/0052A61K41/0057A61P35/00A61K2300/00
Inventor 李贝王琦沈腊珍董川双少敏
Owner SHANXI UNIV
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