Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Rosuvastatin calcium pharmaceutical composition

A technology of rosuvastatin calcium and composition, applied in the directions of drug combination, metabolic diseases, inorganic inactive ingredients, etc., can solve the problems of accelerated degradation reaction, product quality impact, etc. Enhanced control and cost savings

Inactive Publication Date: 2013-04-03
YAOPHARMA CO LTD
View PDF0 Cites 20 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The presence of moisture will accelerate the degradation reaction and have a great impact on the quality of the product

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Prescription 1

[0028]

[0029] Preparation Process

[0030] 1. Mix the internally added materials except magnesium stearate evenly (if necessary, use the method of equal volume addition), then add magnesium stearate and mix evenly.

[0031] 2. Add it to the granulator for dry granulation.

[0032] 3. Add microcrystalline cellulose and crospovidone to the granules, and mix well; then add magnesium stearate and mix well.

[0033] 4. Tablet pressing to obtain the desired product.

Embodiment 2

[0035] Prescription 2

[0036]

[0037] Preparation Process

[0038] 1. Mix the internally added materials evenly (if necessary, use the method of equal volume addition).

[0039] 2. Add it to the granulator for dry granulation.

[0040] 3. The particles are added to the external materials and mixed evenly.

[0041] 4. Tablet pressing to obtain the desired product.

Embodiment 3

[0043] Prescription 3

[0044]

[0045] Preparation Process

[0046] 1. Mix the internally added materials except magnesium stearate evenly (if necessary, use the method of equal volume addition), then add sodium stearyl fumarate and mix evenly.

[0047] 2. Add it to the granulator for dry granulation.

[0048] 3. The granules are added to the external materials and mixed evenly.

[0049] 4. Tablet pressing to obtain the desired product.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a rosuvastatin calcium pharmaceutical composition. The rosuvastatin calcium pharmaceutical composition comprises 1.0 to 10.0% of rosuvastatin calcium, 75 to 97.5% of a low-moisture filler, 0 to 5.0% of a dry binder, 1.0 to 5.0% of a disintegrating agent and 0.5 to 5.0% of a lubricant. Through utilization of the low-moisture filler as an auxiliary material in production, rosuvastatin calcium and other auxiliary materials can be mixed uniformly and the mixture is directly compressed into tablets or is subjected to dry granulation tabletting so that introduction of water in wet granulation is avoided; production energy consumption is reduced; product stability is guaranteed; and a cost is reduced.

Description

technical field [0001] The invention belongs to the field of medicines, and relates to a pharmaceutical composition of rosuvastatin calcium, in particular to a pharmaceutical composition of rosuvastatin calcium containing low-moisture excipients and prepared by dry granulation or direct compression technology substances and their preparation methods. Background technique [0002] Rosuvastatin is a selective HMG-CoA reductase inhibitor. HMG-CoA reductase inhibitors are the rate-limiting enzymes that convert 3-hydroxy-3-methylglutaryl-CoA to mevalonate, the precursor of cholesterol. Rosuvastatin's primary site of action is the liver—the target organ for lowering cholesterol. Rosuvastatin increases the number of hepatic LDL cell surface receptors, promotes the absorption and catabolism of LDL, and inhibits the hepatic synthesis of VLDL, thereby reducing the total number of VLDL and LDL particles. [0003] The small size of rosuvastatin calcium tablet is 5 mg (calculated as r...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/505A61K47/38A61K47/26A61K47/10A61K47/02A61P3/06
Inventor 江月
Owner YAOPHARMA CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com