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Semi-solid Anti-histamine compositions and methods of making and using thereof

A composition, semi-solid technology, applied in the direction of active ingredients of iodine compounds, active ingredients of phosphorus compounds, active ingredients of carbohydrates, etc., can solve problems such as the delivery of active pharmaceutical ingredients that have not yet been used

Pending Publication Date: 2020-08-25
SEATTLE GUMMY CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] While sticky confectionery has been widely used for the delivery of vitamins, it has not been used for the delivery of active pharmaceutical ingredients (APIs)

Method used

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  • Semi-solid Anti-histamine compositions and methods of making and using thereof
  • Semi-solid Anti-histamine compositions and methods of making and using thereof
  • Semi-solid Anti-histamine compositions and methods of making and using thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0110] Example 1. Cetirizine Gelatin Stickies

[0111] Ingredients: Sucrose, Glucose Syrup, Cetirizine Hydrochloride 1.3g, Water, Potassium Sorbate, Sodium Benzoate, Gelatin, Mannitol, Taurine

[0112] Transfer gelatin, mannitol, cetirizine, and taurine together. The dry ingredient mixture was added to water to provide a rubbery mass. Heat the rubbery mass at 160°F until free of foam and clear yellow. Mix water with potassium sorbate, sodium benzoate, dextrose, and sucrose. The solution was heated to 248°F. The solution is then cooled to 200°F and the gelatin solution is added. Stir the mixture until smooth. The solution was then added to the silicone mold and the mold was placed in the refrigerator for 90 minutes. The adhesive sheets were removed from the molds to produce a product containing approximately 11 mg of cetirizine per tablet.

Embodiment 2

[0113] Example 2. Cetirizine stickies

[0114] Carry out as in Example 1, but replace sucrose with palatinose.

Embodiment 3

[0115] Example 3. Cetirizine stickies with low glycemic index sticky base

[0116] Proceed as in Example 1, but replace sucrose with palatinose and replace glucose syrup with allulone syrup.

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PUM

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Abstract

The disclosure provides a semi-solid composition, comprising a gelling component in a sufficient amount to provide a cohesive gelled product, an anti-histamine composition, comprising an antihistamine, and a complexing agent, wherein the complexing agent is capable of interacting with the antihistamine and forming an antihistamine complex. In one embodiment, the antihistamine comprises diphenhydramine, cetirizine, levocetirizine, loratadine, desloratadine, fexofenadine, azelastine, bilastine, rupatadine, or a derivative, salt or a combination thereof.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of U.S. Provisional Application No. 62 / 617,303, filed January 15, 2018, and U.S. Provisional Application No. 62 / 683,523, filed June 11, 2018. Its entire contents are hereby incorporated by reference. technical field [0003] The present invention relates to semi-solid edible or chewable compositions containing one or more biologically active substances therein. Background technique [0004] Unless otherwise indicated herein, the materials described in this section are not prior art to the claims in this invention and are not admitted to be prior art by inclusion in this section. [0005] Sugar is an excellent delivery material for nutrients such as vitamins and minerals. One form of confectionary that is popular for delivering the nutritional section is stickies. Gummy is a chewing confection made primarily of gelling agents, mono- and di-saccharides, and water. Commonly used gel...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/724A61K9/06A61K31/70
CPCA61K9/0056A61K47/26A61K47/36A61K47/40A61K47/42A61K31/495A61K31/135A61K31/4545A61K31/445A61K45/06A61K33/30A61K9/006A61K2300/00A61K47/6951A61K9/06A61K31/015A61K31/047A61K31/05A61K31/07A61K31/122A61K31/355A61K31/375A61K31/40A61K31/405A61K31/4172A61K31/4458A61K31/451A61K31/522A61K31/5415A61K31/55A61K31/554A61K31/593A61K33/04A61K33/06A61K33/14A61K33/18A61K33/24A61K33/26A61K33/32A61K33/34A61K33/42A61K35/748A61K36/064A61K36/16A61K36/185A61K36/258A61K36/28A61K36/484A61K36/53A61K36/534A61K36/537A61K36/752A61K36/87A61K36/88
Inventor 万峰威廉·卡尔森
Owner SEATTLE GUMMY CO
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