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Application of ozone in treatment of sepsis complications caused by noval coronavirus 2019 infection

A 2019-ncov, coronavirus technology, applied in the field of biomedicine, can solve problems such as not having a good treatment method

Inactive Publication Date: 2020-08-25
连云港市东方医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, ALI and ARDS do not have a good treatment so far

Method used

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  • Application of ozone in treatment of sepsis complications caused by noval coronavirus 2019 infection
  • Application of ozone in treatment of sepsis complications caused by noval coronavirus 2019 infection
  • Application of ozone in treatment of sepsis complications caused by noval coronavirus 2019 infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1 The protective effect of ozone autohemotherapy on lung injury in ALI mice

[0044] 1) Establishment of sepsis lung injury (ALI) model

[0045]C57 mice 4-6 weeks old, male, were fed with standard diet for 3 days, weighed the mouse balance, anesthetized by intraperitoneal injection of 5% chloral hydrate (1mg / mL), and injected LPS 5mg / kg through the tail vein to establish the machine. model of lung injury. The control group was injected with the same volume of normal saline. The arterial partial pressure of oxygen (PaO 2 ), lung index (LI), lung permeability index (LPI), and observed the mRNA levels of inflammatory factors IL-β, TNF-α and IL-6 in the lung tissue of mice, which had significant statistical significance, P<0.05 . At the same time, pathological light microscopy was performed on the lung tissue by HE staining to confirm that the ALI modeling was successful.

[0046] 2) The protective effect of AMPK activation on ALI lung injury

[0047] AMPK ago...

Embodiment 2

[0081] Embodiment 2 ozone treatment COVID-19 sepsis lung injury

[0082] 1) Experimental design

[0083] The present embodiment adopts the randomized and controlled research method to compare the effectiveness and safety of the test ozone autohemotherapy on the viral pneumonia caused by the COVID-19 virus. Before conducting this trial, the trial protocol, the proposed informed consent form, and other information provided to the patients were submitted to the Institutional Ethics Committee (IEC) for review.

[0084] According to the relevant provisions of Guoyaojianzhu [2002] No. 437 and the "Measures for the Administration of Drug Registration" (Trial Implementation), a total of 20 pairs of clinical research should be completed (20 cases in the test group and 20 cases in the control group).

[0085] 2) Subject population

[0086] 2.1 Inclusion criteria

[0087] (1) COVID-19 confirmed patients infected with 2019-new coronavirus;

[0088] (2) Age 18-65 years old, gender is not...

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Abstract

The invention discloses an application of medical ozone in preparation of a medicine or preparation for inhibiting or treating sepsis complications caused by human infectious coronavirus, particularlynoval coronavirus 2019, and belongs to the field of biomedicines. According to the invention, medical ozone is used for actively inducing an endogenous anti-inflammatory mechanism to relieve sepsis lung injury, namely, ALI is treated without being limited by a certain single target point on a regulation and control membrane and a related single mechanism of the target, but the ALI is relieved from immunoregulation by actively inducing SOCS3 expression through AMPK to inhibit TLR4-p38-TF / MMP-9. The invention provides a brand-new thought and an excellent target for researching and developing anew anti-ALI drug.

Description

technical field [0001] The invention belongs to the field of biomedicine, in particular, it relates to the application of medical ozone in the preparation of medicines or preparations for the suppression or treatment of sepsis complications caused by human infection with coronavirus, more specifically, it relates to the application of medical ozone in the preparation of Application in drugs or preparations for inhibiting or treating sepsis complications caused by human infection with 2019-novel coronavirus. Background technique [0002] The 2019 novel coronavirus was named 2019-nCoV by the World Health Organization on January 12, 2020. The pneumonia caused by infection with 2019-nCoV is named as Corona Virus Disease 2019 (COVID-19), referred to as "New Coronary Pneumonia". [0003] The lung-based multi-organ damage caused by the inflammatory cytokine storm caused by the virus is the core pathological mechanism of critically ill patients with COVID-19. Severe hypoxia is wide...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/00A61P31/14A61P11/00A61P31/04A61P29/00
CPCA61K33/00A61P11/00A61P29/00A61P31/04A61P31/14
Inventor 何学明朱霞刘文涛
Owner 连云港市东方医院
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