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A kind of salvia safflower extract and its preparation method and application

A technology of safflower extract and salvia, applied in the field of salvia safflower extract and its preparation, can solve problems such as no research report on drug effect, achieve improvement of hemodynamic parameters, reduce side effects, and inhibit lipid permeation. The effect of oxidation

Active Publication Date: 2022-01-14
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Studies in recent years have shown that Danhong Fang contains a large number of plant primary chemical components, but the medicinal effects of such components have not yet been reported.

Method used

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  • A kind of salvia safflower extract and its preparation method and application
  • A kind of salvia safflower extract and its preparation method and application
  • A kind of salvia safflower extract and its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0036] Preparation of Salvia miltiorrhiza and safflower extract: mix salvia miltiorrhiza and safflower medicinal materials at a mass ratio of 3:1, soak twice in 10 times the volume of water at 65°C for 1 hour each time, filter, combine the filtrates, and concentrate to 1 times the volume , to obtain concentrated water extract of Salvia miltiorrhiza-safflower.

[0037] 1. Preparation and detection of primary components of traditional Chinese medicine

[0038] Pass 3 mL of Danshen-safflower concentrated water extract through an open ODS column, and the chromatographic column is filled with 300 g of octadecylsilane-bonded silica gel. Use 0.1% formic acid water, 0.1% formic acid-water methanol (90:10), 0.1% formic acid water-methanol (5:95) for elution, and wash each gradient for 27, 14 and For 1 column volume, the fractions of the first 33 column volumes were collected as D1 and concentrated and dried under reduced pressure; the fractions of the 34th and 35th column volumes were...

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Abstract

The invention provides a salvia safflower extract and a preparation method and application thereof. Through further extraction, the core functional components are effectively screened and retained, the side effects of the drug are reduced, and the functions of inhibiting glucose metabolism and stimulating fatty acid metabolism can improve ischemia and regeneration. Energy metabolism disorders of perfused heart; improve hemodynamic parameters by inhibiting platelet degranulation and aggregation, and prevent the occurrence of thrombosis; up-regulate the level of endogenous metabolic marker taurine against oxidative stress, inhibit lipid peroxidation, It can protect myocardium against oxidative stress injury; it can also inhibit myocardial inflammation caused by ischemia-reperfusion injury through the complement system; it has a significant effect on reducing myocardial ischemia-reperfusion injury in patients with coronary heart disease.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to an extract of salvia miltiorrhiza safflower and its preparation method and application. Background technique [0002] Coronary heart disease (CHD) is a common cardiovascular disease, and its morbidity and mortality are increasing year by year, seriously endangering human life and health. In recent years, percutaneous coronary intervention (PCI) has played an increasingly important role in the treatment of coronary heart disease, but it is easy to cause myocardial ischemia-reperfusion injury (MI / RI). The mechanism of MI / RI includes oxidative stress injury, lipid peroxidation, calcium ion overload, inflammatory response, energy metabolism disorder, cell apoptosis, etc. [0003] Danhong Fang is composed of Danshen and safflower. It has the functions of promoting blood circulation and removing blood stasis, dredging the meridian and soothing the collaterals, el...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61P9/10
CPCA61K36/537A61K36/286A61P9/10A61K2236/331A61K2236/39A61K2236/55A61K2236/51A61K2300/00
Inventor 姜苗苗雷鹏樊官伟曹远林
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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