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Application of specific lectin in identification of pancreatic cancer based on saliva glycoprotein sugar chain structure and related product

A related product, lectin technology, is applied in the direction of analysis of two-dimensional or three-dimensional molecular structure, material inspection products, general structure detailed detection of gas analyzers, etc. It can solve the problems of inability to use early diagnosis and achieve accurate identification Effect

Pending Publication Date: 2020-08-18
深圳格道糖生物技术有限公司
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

Some studies have also suggested that plasma miRNA changes in patients with pancreatic cancer when they are diagnosed, but this change often occurs in the late stage of the disease and cannot be used for early diagnosis

Method used

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  • Application of specific lectin in identification of pancreatic cancer based on saliva glycoprotein sugar chain structure and related product
  • Application of specific lectin in identification of pancreatic cancer based on saliva glycoprotein sugar chain structure and related product
  • Application of specific lectin in identification of pancreatic cancer based on saliva glycoprotein sugar chain structure and related product

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Embodiment Construction

[0026] The relevant experiments and conclusions of the application are introduced below to reveal the scientificity and feasibility of the technical solution of the application. It should be understood that the experiments carried out by the applicant and the manpower and material resources paid for this are not limited to this.

[0027] 1. Experimental part

[0028] 1.1 Reagents and materials

[0029] Epoxy silane reagent (GPTS), Bradford reagent, protease inhibitors, DMSO, Tween-20, and hydroxylamine hydrochloride were all purchased from Sigma Company of the United States, Cy3 and Cy5 fluorescent dyes were constructed from Amerhsam Company of the United States, and Sephadex G-25 columns were purchased from the United States GE Healthcare, the 384-well plate was constructed from Genetix, UK, bovine serum albumin (BSA) was purchased from Calbiochem, Germany, the glass substrate was purchased from Gold Seal, the 0.2 μm filter membrane, and the 0.45 μm filter membrane were purc...

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Abstract

The invention discloses application of specific lectin in identification of pancreatic cancer based on a saliva glycoprotein sugar chain structure and a related product. The specific lectin is dividedinto an up-regulation group and a down-regulation group; the upper regulation group is any one or any combination of lectin ECA, PHA-E, GSL-I, LCA, RCA120, ACA, MAL-I and PHA-E + L, and the lower regulation group is any one or any combination of lectin Jacalin, MAL-II, SJA, MPL, PTL-II, DSA, PWM and SNA; the identification basis is as follows: for a detected saliva sample, if the expression of the glycoprotein carbohydrate chain structure identified by the up-regulation group is significantly up-regulated and the expression of the glycoprotein carbohydrate chain structure identified by the down-regulation group is significantly down-regulated, the corresponding subject is indicated to be a pancreatic cancer patient.

Description

technical field [0001] The invention relates to a related product for identifying pancreatic cancer based on the sugar chain structure of sialoglycoprotein. Background technique [0002] Pancreatic cancer (PC) is a malignant tumor with insidious onset, rapid progression, poor curative effect, short median survival time, and extremely poor prognosis. It is known as the "king of cancers". With the improvement of residents' living standards and the increase of clinical detection rate, the incidence of pancreatic cancer has shown an increasing trend year by year in recent years, becoming an important factor threatening the health of residents. In 2018, there were about 459,000 new cases of pancreatic cancer in the world, and about 432,000 deaths. It is the seventh leading cause of cancer death, and it is predicted that it will even surpass breast cancer and become the third leading cause of death among malignant tumors. Due to the lack of effective screening indicators and almo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574G01N33/68G16H50/20G16B15/00
CPCG01N33/57438G01N33/68G16H50/20G16B15/00G01N2440/38
Inventor 李铮舒健于汉杰唐振张宸
Owner 深圳格道糖生物技术有限公司
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