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Double-layer hydrogel with nano-silver loaded on surface and preparation method of double-layer hydrogel

A surface-loaded, hydrogel technology, applied in medical science, bandages, etc., can solve unsatisfactory problems, achieve the effects of controlling water loss, keeping wounds moist, and excellent biocompatibility

Active Publication Date: 2020-08-11
NORTHWEST UNIV(CN)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The hydrogel dressings currently used clinically can only be used as moisturizing and isolation protection materials, which cannot meet the clinical requirements of absorbing exudate, maintaining moisture for a long time and preventing bacterial infection as wound dressings

Method used

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  • Double-layer hydrogel with nano-silver loaded on surface and preparation method of double-layer hydrogel
  • Double-layer hydrogel with nano-silver loaded on surface and preparation method of double-layer hydrogel
  • Double-layer hydrogel with nano-silver loaded on surface and preparation method of double-layer hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] A kind of preparation method of the double-layer hydrogel of surface loading nano-silver of the present embodiment, comprises the following steps:

[0041] Step 1, dissolving water-soluble chitosan in water to obtain an aqueous solution of chitosan, and dissolving polyvinyl alcohol in water at 70°C to obtain an aqueous solution of polyvinyl alcohol; the number-average molecular weight of the polyvinyl alcohol is 70,000 The mass percentage of chitosan in the chitosan aqueous solution is 14%; the mass percentage of polyvinyl alcohol in the polyvinyl alcohol aqueous solution is 28%;

[0042] Step 2, mixing the chitosan aqueous solution and the polyvinyl alcohol aqueous solution according to the volume ratio of 1:1 according to the step 1, and keeping the mixed solution at 70° C. to obtain the chitosan-polyvinyl alcohol mixed solution;

[0043]Step 3, dissolving powdery polyethylene glycol in the chitosan-polyvinyl alcohol mixed solution described in step 2 until clarificat...

Embodiment 2

[0053] A kind of preparation method of the double-layer hydrogel of surface loading nano-silver of the present embodiment, comprises the following steps:

[0054] Step 1, dissolving water-soluble chitosan in water to obtain an aqueous solution of chitosan, and dissolving polyvinyl alcohol in water at 90°C to obtain an aqueous solution of polyvinyl alcohol; the number-average molecular weight of the polyvinyl alcohol is 120,000 The mass percentage of chitosan in the chitosan aqueous solution is 10%; the mass percentage of polyvinyl alcohol in the polyvinyl alcohol aqueous solution is 26%;

[0055] Step 2, mixing the chitosan aqueous solution and the polyvinyl alcohol aqueous solution according to the volume ratio of 1:1 according to the step 1, and keeping the mixed solution at 90° C. to obtain the chitosan-polyvinyl alcohol mixed solution;

[0056] Step 3, dissolving powdery polyethylene glycol in the chitosan-polyvinyl alcohol mixed solution described in step 2 until clarific...

Embodiment 3

[0066] A kind of preparation method of the double-layer hydrogel of surface loading nano-silver of the present embodiment, comprises the following steps:

[0067] Step 1, dissolving water-soluble chitosan in water to obtain an aqueous solution of chitosan, and dissolving polyvinyl alcohol in water at 90°C to obtain an aqueous solution of polyvinyl alcohol; the number-average molecular weight of the polyvinyl alcohol is 950,000 The mass percentage of chitosan in the chitosan aqueous solution is 10%; the mass percentage of polyvinyl alcohol in the polyvinyl alcohol aqueous solution is 16%;

[0068] Step 2, mixing the chitosan aqueous solution and the polyvinyl alcohol aqueous solution according to the volume ratio of 1:1 according to the step 1, and keeping the mixed solution at 90° C. to obtain the chitosan-polyvinyl alcohol mixed solution;

[0069] Step 3, dissolving the powdery polyethylene glycol in the chitosan-polyvinyl alcohol mixed solution described in step 2 until clar...

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Abstract

The invention discloses double-layer hydrogel with nano-silver loaded on the surface and a preparation method of the double-layer hydrogel. The pore diameter of the upper surface of the double-layer hydrogel with nano-silver loaded on the surface is 2-10 micrometers, the pore diameter of the lower surface is 80-130 micrometers, and the size of the nano-silver is 5-110 nm. The preparation method comprises the following steps: step 1, soaking double-layer hydrogel in a dopamine solution, and performing stirring to obtain dopamine-coated double-layer hydrogel; and step 2, soaking the dopamine-coated double-layer hydrogel in a silver nitrate solution for 5-1200 minutes to obtain the double-layer hydrogel with the nano-silver loaded on the surface. According to the double-layer hydrogel with the nano-silver loaded on the surface, nano-silver particles are uniformly dispersed on the surface, the upper layer is small in pore diameter and compact in structure, the lower layer is large in porediameter and loose in structure, the two layers are tightly combined, and the double-layer hydrogel has excellent biocompatibility and has the functions of blocking bacteria, moisturizing, resisting bacteria, absorbing seepage, adhering to skin, preventing dressing from falling off, promoting wound healing and the like.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a double-layer hydrogel with nano silver loaded on the surface and a preparation method thereof. Background technique [0002] Hydrogel is a water-insoluble soft material with water-holding capacity. This material is soft, can maintain a certain shape, and absorb a large amount of water. The good water absorption of hydrogel makes it a potential application in wound dressings. For wound healing, wound exudate is an unavoidable problem. Wound exudate is the liquid leaking from the wound, and its main component is water. , followed by electrolytes, nutrients, proteins, inflammatory mediators, enzymes, growth factors, metabolic waste, and various cells, etc. Usually, the exudate is transparent and light amber, with uniform viscosity and no smell. For chronic wounds It is said that exudate will delay wound healing, damage the wound bed, degrade extracellular...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0052A61L26/0061A61L26/008A61L26/0085A61L2300/104A61L2300/404A61L2300/412C08L5/08C08L5/04C08L71/02C08L29/04
Inventor 范代娣李阳朱晨辉段志广傅容湛
Owner NORTHWEST UNIV(CN)
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