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Composition containing quinolone compound and edetate compound

A technology of quinolones and compounds, applied in the field of medicine, can solve the problems of unsatisfactory, undesired antibacterial effect of adverse reactions, unsatisfactory antibacterial effect of injection and the like

Active Publication Date: 2021-03-23
ZHONGSHAN WANHAN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the relevant injections in the above two patents are not ideal in terms of antibacterial effect
[0004] In view of the problems of adverse reactions to the human body and unsatisfactory antibacterial effects of related drugs in the prior art, it is urgent to find a composition that has synergistic antibacterial effects on various pathogenic bacteria and can achieve ideal antibacterial effects. antibacterial effect

Method used

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  • Composition containing quinolone compound and edetate compound
  • Composition containing quinolone compound and edetate compound
  • Composition containing quinolone compound and edetate compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0096] Embodiment 1 contains the preparation of the liquid preparation of quinolone compound and edetic acid compound

[0097] The prescription of liquid formulations containing quinolones and edetates is shown in Table 28:

[0098] Table 28. Prescription for Liquid Formulations

[0099]

[0100] Preparation method of injection: take active ingredient, sodium chloride and benzalkonium chloride, add to 600mL water for injection to dissolve under stirring, add water for injection to nearly the total amount, adjust pH to 6.2-6.9 with hydrochloric acid, add water for injection to The whole amount is filtered until clarified, filled into 2mL ampoules, and sterilized by circulating steam at 100°C for 30 minutes.

[0101] Preparation method of eye drops: take the active ingredient, sodium chloride and benzalkonium chloride, add to 600mL water for injection to dissolve under stirring, add water for injection to nearly the total amount, adjust the pH to 6.2-6.9 with hydrochloric ac...

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Abstract

The invention provides a composition containing quinolone compounds and edetic acid compounds, which relates to the field of medical technology, the composition obtained through the reasonable composition and ratio of different quinolone compounds and edetic acid compounds and its The prepared medicine has a synergistic antibacterial effect, and can be used to treat various bacterial infectious diseases including Staphylococcus aureus, Micrococcus lyticus, Streptococcus pneumoniae, Enterococcus faecalis, Escherichia coli and Citrobacter freundii .

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a composition containing quinolone compounds and edetate compounds. Background technique [0002] Disodium edetate, the full name of disodium edetate, is a metal chelating agent commonly used in liquid preparations. However, its antibacterial activity, especially its synergistic antibacterial effect with other antibacterial drugs, has attracted more and more attention. Hui et al. (Niu Hui, He Xinyu, Wang Rui, et al. In vitro antibacterial activity of chelating agents combined with meropenem against carbapenem-resistant Pseudomonas aeruginosa and Klebsiella pneumoniae[J]. Chinese Clinical Pharmacology Journal, 2019, 35(10):971-974.), Li Xuemei (Li Xuemei. Indocyanine green combined with EDTA-mediated photodynamic antibacterial therapy and antibacterial drugs enhance the in vitro antibacterial effect on drug-resistant bacteria in diabetic foot infection[D]. Chongqing ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/198A61K31/4704A61K31/496A61K31/538A61K31/5377A61K31/5383A61P31/04A61K9/08A61K47/02A61K47/18
CPCA61K9/0019A61K9/0048A61K9/08A61K31/198A61K31/4704A61K31/496A61K31/5377A61K31/538A61K31/5383A61K47/02A61K47/186A61P31/04A61K2300/00Y02A50/30
Inventor 冯艺虹杨衍秋谭春霞吕春阳杜志博向飞彭韪
Owner ZHONGSHAN WANHAN PHARM CO LTD
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