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A high-strength autonomous self-healing hydrogel based on dopamine and its preparation method

A hydrogel and dopamine technology, applied in the field of biomaterials, can solve problems such as reducing or even reducing acidity, gelation failure, and hindering acrylamide polymerization

Active Publication Date: 2021-08-20
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But, the content of polydopamine in the polydopamine-polyacrylamide self-healing hydrogel reported in existing literature is low (the mass ratio of dopamine and acrylamide is less than 0.8%, is equivalent to dopamine content and is 0.15wt%) (citing literature: Suneetha M.et al.ACS Omega,2019,vol.4,no.7,pp. 12647–12656.Zhao Z.et al.SciRep,2017,vol.7,no.1,pp.1–10.), This is because dopamine cannot be polymerized simply by increasing the oxidant content in the current research, and H will be generated during the oxidative polymerization of dopamine + , the pH of the solution environment is reduced or even acidic, and the polymerization reaction of dopamine will be inhibited even if the oxidizing agent is used. The polydopamine-polyacrylamide hydrogel of dopamine is difficult to achieve high self-healing efficiency and cannot meet the application requirements

Method used

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  • A high-strength autonomous self-healing hydrogel based on dopamine and its preparation method
  • A high-strength autonomous self-healing hydrogel based on dopamine and its preparation method
  • A high-strength autonomous self-healing hydrogel based on dopamine and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030]In the first step, 0.04 g of dopamine powder was dissolved in 22 mL of sodium hydroxide solution (pH=11) at room temperature, and stirred at pH 8-12 for 2 h to form a polydopamine solution.

[0031] In the second step, at room temperature, mix 5g acrylamide, 8mg N,N'-methylenebisacrylamide and 0.4g ammonium persulfate in polydopamine solution, stir for 10 minutes, then add 60μL tetramethylethylenediamine , acrylamide polymerized within 1 min to form polydopamine-polyacrylamide hydrogel.

[0032] The static self-healing efficiency of the polydopamine-polyacrylamide (dopamine / acrylamide=0.8%) hydrogel obtained in Example 1 was quantitatively evaluated by stretch-repair-stretch test. The pristine gel showed tensile stresses as high as 9.4 kPa ( figure 1 ). In the absence of external stimuli, the repair balance can be reached within 2 hours. The tensile strength recovered to 67% of the intact hydrogel, and the final tensile elongation at break recovered to 70%.

Embodiment 2

[0034] Further, in order to prepare polydopamine-polyacrylamide hydrogel with high dopamine content (dopamine / acrylamide=1.6%), adjust the first step polydopamine preparation process in Example 1: adjust the solution pH and ammonium persulfate content to stimulate dopamine polymerization.

[0035] In the first step, 0.08 dopamine powder was dissolved in 22 mL of sodium hydroxide solution (pH=11) at room temperature, stirred for 1 h, then 0.2 g of ammonium persulfate was added to the solution, and stirred at pH 8-12 for 2 h, A polydopamine solution is formed.

[0036] In the second step, 5g of acrylamide, 3.5mg of N,N'-methylenebisacrylamide and 0.2g of ammonium persulfate were mixed in the polydopamine solution at room temperature. After stirring for 10 minutes, 40 μL of tetramethylethylenediamine was added, and acrylamide polymerized within 1 min to form a polydopamine-polyacrylamide hydrogel.

Embodiment 3

[0038] Further, in order to prepare polydopamine-polyacrylamide hydrogel with high dopamine content (dopamine / acrylamide=5%), adjust the first step polydopamine preparation process in Example 1: adjust the solution pH and ammonium persulfate content to stimulate dopamine polymerization.

[0039] In the first step, 0.25 g of dopamine powder was dissolved in 22 mL of sodium hydroxide solution (pH=11) at room temperature, stirred for 1 h, then 1 g of ammonium persulfate was added to the solution, and stirred at pH 8-12 for 2 h, A polydopamine solution is formed.

[0040] In the second step, 5g of acrylamide, 2.5mg of N,N'-methylenebisacrylamide and 0.2g of ammonium persulfate were mixed in the polydopamine solution at room temperature. After stirring for 10 minutes, 20 μL of tetramethylethylenediamine was added, and acrylamide polymerized within 1 min to form a polydopamine-polyacrylamide hydrogel.

[0041] The synthesis method of Example 3 successfully prepared polydopamine-po...

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Abstract

A dopamine-based high-strength autonomous self-healing hydrogel and a preparation method thereof belong to the field of biomaterials. The mass of the high-strength autonomous self-healing hydrogel is based on 100wt%, and the components and their mass percentages are: the content of polydopamine is 0.15wt% to 0.88wt%, the content of acrylamide is 17.56wt% to 18.18wt%, and the rest is Deionized water. The dopamine is dissolved in the alkaline aqueous solution, the pH is adjusted to 8-14, and the mixture is fully stirred to prepolymerize the dopamine to form polydopamine, thereby obtaining a polydopamine solution. At room temperature, mix acrylamide, N,N'-methylenebisacrylamide and ammonium persulfate with polydopamine solution, stir and mix well, then add auxiliary agent tetramethylethylenediamine to polymerize acrylamide to form Polydopamine-polyacrylamide hydrogel. The present invention adopts a simple two-step method to successfully prepare the polydopamine-polyacrylamide hydrogel. The high-strength hydrogel has good self-healing performance, and the hydrogel can be recovered without external stimuli after being damaged and broken. Quickly restore its mechanical properties.

Description

technical field [0001] The invention belongs to the field of biomaterials, and relates to a dopamine-based hydrogel with high mechanical strength and autonomous self-healing properties and a preparation method thereof. Background technique [0002] Dopamine-based functional hydrogels have good biocompatibility, strong cell adhesion, good self-healing properties, and strong tissue adhesion properties, making dopamine-based functional hydrogels widely used in biomaterials, tissue engineering and many other fields. The field has broad applications and has become one of the research hotspots in the field of hydrogel functional materials. [0003] Dopamine-based self-healing hydrogels usually require external stimulation (light irradiation) or metal chelation to achieve the self-healing process. However, for hydrogels implanted in organisms, it is difficult to apply external stimuli, and the potential biological toxicity of metal ions limits their applications in the biomedical ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L33/26C08L79/04C08J3/075C08F220/56C08F222/38C08G73/06
CPCC08F220/56C08G73/0672C08J3/075C08J2333/26C08J2479/04C08F222/385
Inventor 张伟黄金鑫吴承伟
Owner DALIAN UNIV OF TECH
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