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Compound whitening and spot-removing patch with quantitatively released functional components and preparation method thereof

A technology of functional ingredients and freckle patches, which is applied in the field of compound whitening and freckle-removing patches and its preparation, can solve the problems that the amount entering the skin cannot be controlled and measured, and the effect is slow and inaccurate. The method is simple, freckle-removing, The effect of promoting metabolism

Inactive Publication Date: 2020-08-07
无锡元旭生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Aiming at the deficiencies of the above-mentioned prior art, the present invention provides a compound whitening and freckle-removing patch with quantitative release of functional components, the purpose of which is to solve the slow and inaccurate effect of existing whitening and freckle-removing products, which are also prone to skin problems such as allergies, and due to keratin The barrier function of the skin layer, the whitening ingredients can not penetrate into the subcutaneous tissue to play a role, and the amount entering the skin is completely impossible to control and measure the technical problems

Method used

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  • Compound whitening and spot-removing patch with quantitatively released functional components and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The tranexamic acid powder and the nicotinamide powder were thoroughly mixed through a dry mixer at a ratio of 1:20, and the mixed powder was weighed by high pressure and pressed into the concave hole of the microneedle mold, and the excess part was removed and removed. Weighing and decrement method can get the amount that actually enters the concave hole of the microneedle mold, and can calculate the content of the functional ingredients (tranexamic acid and nicotinamide) actually in each concave hole. Then pour the dissolved sodium hyaluronate skeleton aqueous solution into the mold, and dry it to make a tranexamic acid / nicotinamide compound microneedle patch. The tranexamic acid and niacinamide are concentrated at the needle tip, and after piercing the skin, It can quickly dissolve and penetrate in the body, and the actual amount that enters the skin can be calculated according to the number of needles pierced.

Embodiment 2

[0020] The tranexamic acid powder and the nicotinamide powder were thoroughly mixed with a dry blender at a ratio of 20:1, and the mixed powder was weighed by high pressure and pressed into the concave hole of the microneedle mold, and the excess part was removed and removed. Weighing and decrement method can get the amount that actually enters the concave hole of the microneedle mold, and can calculate the content of the functional ingredients (tranexamic acid and nicotinamide) actually in each concave hole. Then pour the dissolved sodium hyaluronate skeleton aqueous solution into the mold, and dry it to make a tranexamic acid / nicotinamide compound microneedle patch. The tranexamic acid and niacinamide are concentrated at the needle tip, and after piercing the skin, It can quickly dissolve and penetrate in the body, and the actual amount that enters the skin can be calculated according to the number of needles pierced.

Embodiment 3

[0022] The tranexamic acid powder and the nicotinamide powder were thoroughly mixed with a dry blender at a ratio of 1:10, and the mixed powder was weighed by high pressure and pressed into the concave hole of the microneedle mold, and the excess part was removed and removed. Weighing and decrement method can get the amount that actually enters the concave hole of the microneedle mold, and can calculate the content of the functional ingredients (tranexamic acid and nicotinamide) actually in each concave hole. Then pour the dissolved sodium hyaluronate skeleton aqueous solution into the mold, and dry it to make a tranexamic acid / nicotinamide compound microneedle patch. The tranexamic acid and niacinamide are concentrated at the needle tip, and after piercing the skin, It can quickly dissolve and penetrate in the body, and the actual amount that enters the skin can be calculated according to the number of needles pierced.

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Abstract

The invention belongs to the field of skin care products, the invention particularly relates to a preparation method of a compound whitening and spot-removing patch with quantitatively released functional components. A microneedle patch is prepared from tranexamic acid and nicotinamide through a special mixing and adding method, the method is simple, effective components can permeate into subcutaneous tissues through microchannels formed after the soluble microneedle pierces into the skin, the amount of the effective components actually entering the skin can be accurately controlled and metered, and then the spot removing effect is achieved to the maximum extent. The invention further provides the compound whitening and spot-removing patch with quantitatively released functional components. The compound whitening and spot-removing patch is high in biological safety and excellent in effect.

Description

technical field [0001] The invention belongs to the field of skin care products, and in particular relates to a compound whitening and freckle-removing patch with quantitative release of functional ingredients and a preparation method thereof. Background technique [0002] Pigmentation is a general term for all dark spots on the skin due to the stimulation of various internal and external factors. Most of them belong to brown or black pigmentation plaques formed by the increase or slow elimination of melanin synthesis on the surface of the skin. The whitening products currently available in the market have slow and inaccurate effects, and are likely to cause skin problems such as allergies, and because of the barrier function of the stratum corneum, the whitening ingredients cannot penetrate into the subcutaneous tissue to play a role, and the amount of entering the skin is completely small. methods of control and measurement. Contents of the invention [0003] Aiming at ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/67A61K8/44A61K8/02A61Q19/02A61M37/00
CPCA61K8/675A61K8/44A61K8/0208A61Q19/02A61M37/0015A61K2800/782A61K2800/592A61K2800/805A61M2037/0046A61M2037/0053A61M2037/0061
Inventor 杨淑艳赵科研郭文平
Owner 无锡元旭生物技术有限公司
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