Drug delivery device, preparation method thereof, and drug delivery system

Abstract

The invention provides a drug delivery device, a preparation method thereof and a drug delivery system, comprising a catheter body, a balloon arranged at the distal end of the catheter body, and a pressure monitoring and adjusting device connected to the filling cavity and the drug delivery cavity of the catheter body, the balloon The shape of the balloon after filling is attached to the inner wall of the target cavity, and at least one drug delivery port is provided at the far end of the drug delivery cavity, and the drug is directly delivered to the outer surface of the balloon through the drug delivery port, and the compliant balloon The outer surface of the drug delivery port directly acts on the inner wall of the target cavity, and the drug delivery efficiency and drug utilization rate are high, and the aperture and number of the drug delivery port match the viscosity of the drug, and are configured to inject the drug at a certain time. Under the pressure, the drug can be delivered at a certain volume flow rate, so that under the monitoring and / or adjustment of the pressure monitoring and adjusting device, the drug can be delivered at the rated pressure and flow rate, which is suitable for different natural orifices. Dosing needs, to help uniform dosing.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a drug delivery device, a preparation method thereof, and a drug delivery system. Background technique [0002] In clinical treatment, drugs can be delivered to multiple natural orifices of the animal body, especially the human body, such as reproductive natural orifices, respiratory tracts (nasal tubes, pharyngeal tubes, trachea and bronchi), digestive tracts (esophagus and rectum) or other natural orifices. In these treatments, the drug needs to be delivered to the inner wall of the target cavity uniformly and quickly, and in most cases, the drug is also required to be effectively used to minimize waste. The drug delivery carriers currently on the market have various defects, such as low drug delivery efficiency and drug utilization, inability to uniform drug delivery, and drug delivery carriers are likely to cause secondary damage to the target cavity, which cannot meet the nee...

AI Technical Summary

Problems solved by technology

[0004] Based on the above prior art, the inventors found that there are at least the following technical problems in the prior art: First, due to the limited interlayer space of the balloon, and the inflation of the balloon will cause the interlayer space to be further compressed, a large amount of drugs remain in the interlayer, causing drug Waste, low drug utilization, and poor operability; further led to prolonged operation time and increased unnecessary pain for patients

Secondly, the double-layer structure of the balloon also leads to a larger overall outer diameter of the drug delivery device, especially the balloon part, which is difficult to insert into the target cavity and may cause damage to the target cavity

In addition, in the prior art drug delivery device, after the balloon is inflated, the distal end of the catheter body exceeds the balloon more, which easily scratches the inner wall of the target cavity, causing secondary damage

[0005] At the same time, the catheter body of the existing drug delivery device is mostly made of soft materials such as silica gel, which has poor support and needs instrument assistance when entering the target cavity, which not only increases the difficulty of use, but may also bring some physiological pain to the patient

And because the curvature of the target cavity of different patients is different, there may be a large curvature, even with the aid of equipment, it is still impossible to insert into the target cavity

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