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Parthenocissus tricuspidata-imitated adhesion microcarrier and preparation method thereof

A microcarrier and creeper technology, applied in the field of drug microcarrier research, can solve the problems of less use of colloidal crystals, and achieve the effects of low cost, enhanced adhesion effect and high versatility

Inactive Publication Date: 2020-08-04
NANJING DRUM TOWER HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, to the best of our knowledge, the assembly of colloidal crystals is rarely used for complex drug carrier design

Method used

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  • Parthenocissus tricuspidata-imitated adhesion microcarrier and preparation method thereof
  • Parthenocissus tricuspidata-imitated adhesion microcarrier and preparation method thereof
  • Parthenocissus tricuspidata-imitated adhesion microcarrier and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0029] A creeper-imitating adhesive microcarrier and its preparation method, specific implementation steps:

[0030] (1) Preparation of droplet template:

[0031] Based on the capillary assembly microfluidic chip, the silicon dioxide aqueous solution with a mass fraction of 20% was used as the discrete phase, the flow rate was 0.15ml / h, and the propylene carbonate was used as the continuous phase, and the flow rate was 15ml / h. Single emulsion with controllable diameter and uniform size.

[0032] (2) Deformation and solidification of the droplet template:

[0033] The single-emulsion template prepared in step (1) is placed in a vertical channel filled with propylene carbonate, and the droplets fall freely in this environment, and are deformed into micron particles with a creeper-like antennae structure due to rapid solvent extraction.

[0034] (3) Obtaining of hydrogel microcarriers:

[0035] First, place the dried template particles in a high-temperature gelatin liquid, sti...

Embodiment 2

[0039] A creeper-imitating adhesive microcarrier and its preparation method, specific implementation steps:

[0040] (1) Preparation of droplet template:

[0041] Based on the capillary assembly microfluidic chip, the silicon dioxide aqueous solution with a mass fraction of 20% is used as the discrete phase, the flow rate is 0.15ml / h, and the ethyl acetate is used as the continuous phase, the flow rate is 15ml / h, and the particle size can be controlled. , single emulsion of uniform size.

[0042] (2) Deformation and solidification of the droplet template:

[0043] The single-emulsion template prepared in step (1) was placed in a vertical channel filled with ethyl acetate, and the droplets fell freely in this environment, and deformed into micron particles with a creeper-like antennae structure due to rapid solvent extraction.

[0044] (3) Obtaining of hydrogel microcarriers:

[0045] First, place the dried template particles in a high-temperature gelatin liquid, stir the ge...

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Abstract

The invention relates to a parthenocissus tricuspidata-imitated adhesion microcarrier and a preparation method thereof. Monodisperse droplets prepared by a microfluidic device are self-assembled in arapid solution extractant to form micron particles with parthenocissus tricuspidata morphology, the micron particles are used as a template, functional hydrogel with good biocompatibility is used forcopying the structure of the micron particles, and the template is removed to obtain the parthenocissus tricuspidata-imitated adhesion microcarrier. The microcarrier has a bionic macroscopic morphology, the contact area is increased, the adhesion effect is enhanced, the porous microstructure provides a large area for drug fixation, and a good carrier is provided for prolonging the drug release time through long-time retention of the drug in a complex environment through adhesion. The preparation method provided by the invention is simple and easy to implement, low in cost and convenient for large-scale production, and the prepared microcarrier is non-toxic and has excellent biocompatibility, biological functionality and biodegradability. And a new carrier is provided for safe and efficientdrug delivery.

Description

technical field [0001] The invention relates to the technical field of drug microcarrier research, in particular to a creeper-like adhesive microcarrier and a preparation method thereof. Background technique [0002] Drug therapy is an important means of treatment of many diseases. Drugs are delivered to their specific action sites in the body through different administration methods to achieve therapeutic effects. A drug carrier is a carrier used to load drugs for delivery. By wrapping drug molecules in the carrier matrix or attaching to the surface of the carrier, not only can the effective transmission and delivery of drugs be achieved, but also the degradation or response of functional materials can be used. Sexual behavior realizes functions such as sustained release and controlled release of drugs. In recent years, great progress has been made in particulate drug carriers for safer and more efficient drug delivery. Among them, microparticles are considered to be one...

Claims

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Application Information

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IPC IPC(8): A61K47/69A61K47/42A61K47/02A61K47/32B01L3/00A61M31/00
CPCA61K47/02A61K47/32A61K47/42A61K47/6903A61M31/00A61M2206/00A61M2210/1042A61M2210/105A61M2210/1053B01L3/502746B01L2300/0819A61M2210/005
Inventor 赵远锦蔡丽均王月桐
Owner NANJING DRUM TOWER HOSPITAL
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