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Application of astilbin organic acid composition in treatment of psoriasis

A technology of astilbin and organic compounds, which is applied in the field of traditional Chinese medicine components and compositions for the treatment of psoriasis, which can solve problems such as intolerance, expensive biological preparations, and high drug toxicity, and achieve good results

Active Publication Date: 2020-07-28
GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Topical drugs are only suitable for mild patients, systemic drugs are highly toxic and difficult to tolerate, and biological agents are expensive and their safety needs long-term evaluation

Method used

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  • Application of astilbin organic acid composition in treatment of psoriasis
  • Application of astilbin organic acid composition in treatment of psoriasis
  • Application of astilbin organic acid composition in treatment of psoriasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Microemulsion preparation

[0036] prescription:

[0037]

[0038]

[0039] Preparation method:

[0040] According to the above prescription, weigh macrogol glyceride oleate (Labrafil M 1944Cs), polyoxyethylene 40 hydrogenated castor oil and diethylene glycol monoethyl ether (Transcutol HP), stir well, add astilbin and For gallic acid, continue to stir until the medicinal powder is completely dissolved, add distilled water, continue to stir at a constant speed to obtain colostrum, and ultrasonicate the colostrum to form a white and transparent O / W type microemulsion of traditional Chinese medicine components.

Embodiment 2

[0042] Preparation of emulsion

[0043] prescription

[0044]

[0045] Preparation method:

[0046] According to the above prescription, weigh polyethylene glycol glyceride oleate (Labrafil M 1944Cs), polyoxyethylene 40 hydrogenated castor oil (RH40) g, diethylene glycol monoethyl ether (Transcutol HP) g, stir and mix, Add taxifolin and citric acid, wait until the powder is completely dissolved, slowly add distilled water, continue stirring at a constant speed to obtain colostrum, and obtain an opaque emulsion after ultrasonication of the colostrum.

Embodiment 3

[0048] Preparation of cream:

[0049] prescription:

[0050]

[0051]

[0052] Preparation method:

[0053] According to the above prescription, weigh the oil phase, stearyl alcohol, white petrolatum, glyceryl monostearate, water phase, Tween 80, glycerin, ethylparaben, distilled water, put the oil phase and water phase in 80 In a water bath at ℃, after it is completely dissolved, slowly pour the water phase into the oil phase, stir while adding, until uniform, add neoastilbin and glycyrrhetinic acid, continue stirring until cooling, and obtain the product.

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Abstract

The invention discloses an application of an astilbin organic acid composition in treatment of psoriasis. The astilbin organic acid composition comprises astilbin or a structural analogue thereof andan organic acid in any ratio. The composition has the beneficial effects that astilbin and organic acid are combined, so that the effect of preventing or treating psoriasis is good, and the pharmaceutical composition is safe and non-toxic and does not have side effects caused by hormones.

Description

technical field [0001] The invention belongs to the technical field of treating psoriasis, in particular to a traditional Chinese medicine component composition for treating psoriasis. Background technique [0002] Psoriasis is an immune abnormal chronic proliferative skin disease determined by polygenic inheritance and stimulated by multiple environmental factors. Its histopathological features mainly include hyperplasia of keratinocytes, infiltration of inflammatory cells, and neovascularization. [0003] The etiology of psoriasis is complex and recurrent, difficult to cure. At present, the commonly used therapeutic drugs in clinical practice mainly include local topical drugs, systemic therapeutic drugs, biological agents and so on. Topical drugs are only suitable for mild patients, systemic drugs are highly toxic and difficult to tolerate, and biological agents are expensive and their safety needs long-term evaluation. Therefore, both international and domestic effort...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K45/06A61P17/06
CPCA61K31/7048A61K45/06A61P17/06A61K2300/00
Inventor 卢传坚赵瑞芝刘丽娟韩凌赵亚吴亚运
Owner GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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