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Application of medicines for promoting non-alcoholic fatty liver cell lipid metabolism

A non-alcoholic, hepatocellular technology, applied in the field of drug preparation, to achieve the effects of reducing lipid deposition and lipotoxicity, improving lipid metabolism, and clear chemical structure

Inactive Publication Date: 2020-07-28
GUANGXI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there is no specific drug for NAFLD clinically, and most of them choose the appropriate drug for treatment according to the symptoms

Method used

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  • Application of medicines for promoting non-alcoholic fatty liver cell lipid metabolism
  • Application of medicines for promoting non-alcoholic fatty liver cell lipid metabolism
  • Application of medicines for promoting non-alcoholic fatty liver cell lipid metabolism

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0012] 1. Preparation of Asiatic Acid

[0013] Extraction and separation method:

[0014] After 10 kg of dried Potentilla was crushed, it was extracted 3 times with 80L of 75% ethanol under reflux and reflux. The 3 ethanol extracts were combined to recover the ethanol to obtain the ethanol extract; the crude extract was mixed with sodium hydroxide solution, The pH of the mixed solution is 7.5-8.5; the crude extract is fed into the macroporous resin column, washed with water until it is colorless, and then washed with 20-25% ethanol solution and 50-75% ethanol solution respectively, and collect 50-75 % Ethanol eluent to obtain the alcohol extract, and then concentrate and dry to obtain the extract; dissolve the extract in 3-5 times the volume of water at 45-55°C, then add 630ml of ethyl acetate as the solvent for extraction 1- 3 times, combine the extracts and concentrate to 1.02-1.05g / ml; pass the extracts through a silica gel column, first wash the column with 30-35% ethanol solu...

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Abstract

The invention discloses an application of medicines for promoting non-alcoholic fatty liver cell lipid metabolism, and particularly relates to an application of an activated monomer component namely asiatic acid of a traditional Chinese medicine namely herba potentillae chinensis. The monomer compound namely the asiatic acid can be separated from the traditional Chinese medicine namely herba potentillae chinensis, so that the asiatic acid can be proved to effectively restrain activation and multiplication of non-alcoholic fatty liver cells, and lipidoses, oxidation stress and an inflammatory reaction in the non-alcoholic fatty liver cells can be alleviated. The non-alcoholic fatty liver cell lipid metabolism can be improved. The traditional Chinese medicine monomer can relieve the problemthat the non-alcoholic fatty liver is poor in treatment effects, and a novel compound being clear in chemical structure and efficient can be provided for treatment of non-alcoholic fatty liver.

Description

Technical field [0001] The invention relates to a preparation method and application of a medicine, in particular to a method for extracting and separating asiatic acid, an active monomer component of Chinese medicine Potentilla chinensis; asiatic acid promotes lipid metabolism of non-alcoholic fatty liver cells And application. Background technique [0002] Non-alcoholic Fatty Liver Disease (NAFLD) is a metabolic syndrome characterized by liver lipid deposition without a history of excessive drinking. NAFLD is divided into two categories: primary and secondary. Primary NAFLD is mainly closely related to obesity, insulin resistance (IR), diabetes and dyslipidemia, and secondary NAFLD is mainly related to factors such as drugs and viruses. After surveying the population of 21 countries, it was found that the incidence of NAFLD accounted for approximately 24.24%. In the past two decades, the prevalence of NAFLD has more than doubled, mostly in men and obese. According to reports...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/56A61P1/16
CPCA61K31/56A61P1/16
Inventor 韦锦斌林兴王丹丹劳玲玲庞小红乔倩何赟
Owner GUANGXI MEDICAL UNIVERSITY
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