Pyrolytic diterpenoid alkaloid compound as well as preparation method and application thereof

Abstract

The invention provides a pyrolytic diterpenoid alkaloid compound shown as a formula I shown in the specification, or a salt, a stereoisomer or a solvate thereof, and a preparation method of the pyrolytic diterpenoid alkaloid compound. The invention also provides application of the compound or the salt thereof, the stereoisomer thereof or the solvate thereof in preparing medicines for preventing and / or treating ventricular premature beat, ventricular tachycardia and antiarrhythmia, and the clinical prospect is excellent.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to a pyrolysis type diterpene alkaloid compound and its preparation method and application. Background technique [0002] Arrhythmia is a clinically common and very dangerous cardiovascular disease. For a long time, people have been devoting themselves to the research of antiarrhythmic drugs, but there has been no obvious breakthrough in more than 20 years. [0003] Clinical treatment of arrhythmias can use antiarrhythmic drugs, or choose radiofrequency ablation and implantable automatic cardioverter defibrillator (ICD). [0004] Antiarrhythmic drugs still play an important role in the treatment of arrhythmias for the following reasons: (1) Most tachyarrhythmias require drugs to terminate the attack during acute attacks; (2) Some supraventricular premature beats and premature ventricular beats that cause symptoms need to be controlled with drugs and prevention of recurrence; ③Patients with...

AI Technical Summary

Problems solved by technology

However, the processing principle of the sand-frying method has not been fully elucidated. How does the structure of the toxic alkaloid transform during the sand-frying process? Is the toxicity of the transformed product reduced compared with the original alkaloid? And because the processing principle of the sand-frying method has not been clarified, the quality evaluation of the sand-stir-fried processed products is still judged by subjective experience such as: the medicinal materials are fried until "the outer skin is burnt yellow, and the cross-section is yellow", and there is a lack of quantitative quality control indicators.

In addition, studies have shown that although some diterpene alkaloids have similar structures, they have opposite effects. For example, some can cause arrhythmia and have cardiotoxicity, while others have the effect of treating arrhythmia.

Images