Biological valve with anticoagulation and anti-calcification functions and preparation method thereof
A biological valve and anticoagulation technology, applied in the field of medical materials and medical device preparation, can solve problems such as coagulation of interventional pulmonary valve, improve long-term anticoagulation and anticalcification performance, eliminate immunogenicity, reduce coagulation and calcification Effect
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Embodiment 1
[0033] A method for preparing a biological valve with anticoagulant and anticalcification functions, the specific process is:
[0034] (1) After cleaning the porcine pericardial valve with deionized water, soak it in an aqueous solution of 0.5% glucosamine and 1% condensing agent at 4°C for 2 days;
[0035] (2) Soak in 1% glutaraldehyde solution at 4°C for 7 days;
[0036] (3) Soak in 3% taurine aqueous solution at 4° C. for 2 days to obtain the target biological valve material.
[0037] The tensile fracture stress of the anti-calcification biological heart valve prepared in this implementation is 36N under the uniaxial tensile test (1*5cm sample size).
[0038] The platelet adhesion experiment found that the biovalve prepared in this implementation has significantly improved anticoagulant performance compared with the traditional glutaraldehyde cross-linked valve.
[0039] The experiment of subcutaneous implantation in rats found that the anti-calcification effect of the bi...
Embodiment 2
[0041] A method for preparing a biological valve with anticoagulant and anticalcification functions, the specific process is:
[0042] (1) After the bovine pericardial valve is cleaned with deionized water, soak it in an ethanol aqueous solution of 1% perfluorooctanoic acid-2-aminoethyl ester and 3% condensing agent at 4°C for 2 days;
[0043] (2) Soak in 5% glutaraldehyde solution at 4°C for 7 days;
[0044] (3) Soak in 1% perfluorobutylamine ethanol aqueous solution at 4° C. for 2 days to obtain the target biological valve material.
[0045] The tensile fracture stress of the anti-calcification biological heart valve prepared in this implementation is greater than 30N under the uniaxial tensile test (1*5cm sample size).
[0046] The platelet adhesion experiment found that the biovalve prepared in this implementation has significantly improved anticoagulant performance compared with the traditional glutaraldehyde cross-linked valve.
[0047]The subcutaneous implantation exp...
Embodiment 3
[0049] A method for preparing a biological valve with anticoagulant and anticalcification functions, the specific process is:
[0050] (1) After cleaning the porcine pericardial valve with deionized water, soak it in a glutaraldehyde solution with a concentration of 3% for 7 days at 4°C;
[0051] (2) at 4°C, soak for 5 days in an aqueous ethanol solution with a concentration of 2% (2-aminoethyl)-perfluorooctylamide and a concentration of 5% condensing agent;
[0052] (3) Soak in 3% perfluorooctylamine ethanol aqueous solution at 4°C for 5 days to obtain the target biological valve material.
[0053] The tensile fracture stress of the anti-calcification biological heart valve prepared in this implementation is greater than 30N under the uniaxial tensile test (1*5cm sample size).
[0054] The platelet adhesion experiment found that the biovalve prepared in this implementation has significantly improved anticoagulant performance compared with the traditional glutaraldehyde cross...
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