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Self-pushing hemostatic gauze/dressing

A technology of hemostatic gauze and weak acid and strong base salt, which is applied in the fields of medical science, absorbent pads, pharmaceutical formulations, etc., can solve the problems of difficult and irregular surface sealing of wounds, expensive solid tissue sealants, etc., achieves good hemostatic effect, is easy to prepare and Effects of use, flexibility preparation and use

Inactive Publication Date: 2020-07-17
浙江西安交通大学研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, solid tissue sealants are more expensive and difficult to seal wounds on irregular surfaces

Method used

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  • Self-pushing hemostatic gauze/dressing
  • Self-pushing hemostatic gauze/dressing
  • Self-pushing hemostatic gauze/dressing

Examples

Experimental program
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Effect test

preparation example Construction

[0085] CaCO 3 The preparation method of the particles is as follows: 0.33M Na 2 CO 3 Add to an equal volume of 0.33M CaCl 2 Medium and rapid mixing at 400 or 800 rpm, the precipitated CaCO 3 The particles can be purified by centrifugation (3,000 g, 10 min), and after washing three times with deionized water, the CaCO 3 Granules, freeze, dry in vacuum (-70°C, 30 Pascal) to constant weight; get CaCO 3 Microparticles (approximately 100 or 50 μm in size)

[0086] C-CaCO 3 Particles can be produced by Alfa Aesar, ACS grade, CaCO with a particle size of about 150 μm 3 particle.

[0087] The fibrinogen concentrate (containing coagulation factor XIII) can be RiaSTAP produced by CSL Behring.

[0088] Thrombin can be selected from the thrombin produced by Haematologic Technologies (specific activity = 3,650 U / mg.

[0089] TXA-NH 3 + The preparation method is:

[0090] Add 6M HCl to 0.5M tranexamic acid (TXA-NH 2 ) in aqueous solution up to pH 4.3. The acidified solution wa...

Embodiment 1-1

[0094] Example 1-1, CaCO loaded with fibrinogen 3 The preparation method of granular gauze, carries out following steps successively:

[0095] 1) Add the fibrinogen concentrate to the 10mM HEPES (4-hydroxyethylpiperazineethanesulfonic acid) aqueous solution according to the feed concentration of 20mg / ml to obtain a mixed solution;

[0096] 2), 329.5mg commercial or self-made CaCO 3 Particles (1-200 μm) are mixed with 3.295 ml of the mixture obtained in step 1) to obtain a mixture;

[0097] Pour the mixture over a 5 x 5cm 2 Gauze, frozen at -70 °C, and vacuum-dried at 30 Pa to constant weight; CaCO loaded with fibrinogen 3 Granular gauze.

[0098] Description: HEPES has a protective effect on the activity of fibrinogen.

Embodiment 1-2

[0099] Embodiment 1-2, the preparation method of gauze containing protonated tranexamic acid, the following steps are carried out successively:

[0100] Add 6M HCl to 0.5M tranexamic acid (TXA-NH2 ) in aqueous solution up to pH 4.3. The acidified solution was frozen at -70 °C at 30 Pa and vacuum dried to constant weight to obtain solid TXA-NH 3 + .

[0101] The TXA-NH 3 + with CaCO 3 The reaction produces bubbles of carbon dioxide, which it uses to propel itself.

[0102] 329.5mg TXA-NH 3 + Dissolve in 3.4ml water, then pour on 5×5cm 2 On 4 layers of gauze, freeze at -70°C and vacuum-dry at 30 Pascals to constant weight to obtain gauze containing protonated tranexamic acid.

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Abstract

The invention discloses a self-pushing hemostatic gauze / dressing. The self-pushing hemostatic gauze / dressing comprises a component A and a component B which have good biocompatibility; the component Aand the component B generate gas when meeting liquid, and the gas generates conveying capacity opposite to the moving direction of the flowing liquid. The component A is a weak acid strong base saltcontaining a bioactive substance, and the component B is a protonated solid acid, wherein the bioactive substance has functions of accelerating coagulation and reducing hemolysis. The invention changes the defects that existing tissue sealants and hemostatic gauze are only limited to accessible bleeding parts and the like, so that the self-pushing hemostatic gauze / dressing has a wider applicationrange and a better hemostatic effect.

Description

technical field [0001] The present invention relates to self-propelling hemostatic gauzes / dressings. Background technique [0002] Major bleeding occurs in many critical care situations, including accidental trauma, battlefield trauma, cardiac surgery, liver transplantation, postpartum hemorrhage, dental surgery, and hemorrhage in patients with hemophilia. Severe bleeding, which occurs in up to 40% of trauma patients and 10% of cardiac surgery patients, is an important cause of morbidity and mortality. Highway motor vehicle crashes are the leading cause of death for adults under the age of 40. Furthermore, blood loss is one of the major causes of morbidity after liver transplantation and one of the most common causes of death in women during childbirth. [0003] Although control of secondary bleeding, infection, and tissue repair are also important, the first-line treatment during severe bleeding is rapid control of blood loss. Delivery of appropriate therapeutic agents s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/44A61L15/32A61L15/18A61L15/20A61L15/42
CPCA61L15/18A61L15/20A61L15/32A61L15/42A61L15/425A61L15/44A61L2300/252A61L2300/254A61L2300/418A61L2400/04C08L89/00
Inventor 彭涛
Owner 浙江西安交通大学研究院
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