A long usnea derivative and its use in the preparation of drugs for the treatment of gallbladder cancer

A derivative, the technology of Usnea longiflora is applied in the application field of preparing a drug for treating gallbladder cancer, can solve problems such as kidney toxicity, and achieve the effects of less cytotoxicity, less side effects, and reduced side effects

Active Publication Date: 2020-11-20
山西白求恩医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, commonly used chemotherapeutic drugs for gallbladder cancer include mitomycin, fluorouracil, paclitaxel, and cisplatin. These drugs have their own advantages and disadvantages. Cisplatin has the advantages of broad anti-cancer spectrum and strong effect, but it is easy to cause nephrotoxicity

Method used

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  • A long usnea derivative and its use in the preparation of drugs for the treatment of gallbladder cancer
  • A long usnea derivative and its use in the preparation of drugs for the treatment of gallbladder cancer
  • A long usnea derivative and its use in the preparation of drugs for the treatment of gallbladder cancer

Examples

Experimental program
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Effect test

Embodiment 1

[0047] The preparation of embodiment 1 long usnelain injection

[0048] S1: liquid preparation, take 10 mg of the compound Usnea sinensis represented by formula II and dissolve it in 20 mL of sodium chloride injection to prepare a drug solution with a drug concentration of 0.5 mg / mL;

[0049] S2: Activated carbon treatment, adding 0.2% of the total amount of the solution to the medicinal solution and treating it with activated carbon for 0.5 hours;

[0050] S3: initial filtration, filter the liquid medicine with filter paper;

[0051] S4: Sterilize by filtration, use a microporous filter membrane with a pore size of 0.22 μm to sterilize the medicinal solution and remove the heat source;

[0052] S5: Subpackage the medicinal solution in units of 2 mL, fill and seal to obtain an injection solution.

Embodiment 2

[0053] Example 2 Preparation of Chang Usnequin-Cisplatin Compound Injection

[0054] S1: Prepare solution, take 10 mg of the compound Unemeline shown in formula II and 30 mg of cisplatin and dissolve it in 20 mL of sodium chloride injection, the concentration of prepared Unequin is 0.5 mg / mL, and the concentration of cisplatin is 1.5 mg / mL compound liquid medicine;

[0055] S2: Activated carbon treatment, adding 0.2% of the total amount of the solution to the medicinal solution and treating it with activated carbon for 0.5 hours;

[0056] S3: initial filtration, filter the liquid medicine with filter paper;

[0057] S4: Sterilize by filtration, use a microporous filter membrane with a pore size of 0.22 μm to sterilize the medicinal solution and remove the heat source;

[0058] S5: Subpackage the medicinal solution in units of 2 mL, fill and seal to obtain an injection solution.

[0059] Here the applicant needs to emphasize that the mass ratio of usnecelein and cisplatin c...

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Abstract

The invention provides an usnea longifolia derivative and application thereof in preparation of a medicine for treating gallbladder cancer. The usnea longifolia derivative has a chemical name of 3, 6-diacetyl-2, 7, 9-trihydroxy-8, 9b-dimethyl-1 (9bH)-dibenzofuranone, has an effect of inhibiting activity of human gallbladder cancer cells and has a small toxic effect on normal cells. The compound can be independently used in the treatment of gallbladder cancer and can also be used in combination with other drugs. The inventor of the invention unexpectedly finds that the compound can achieve a better effect of inhibiting cholecystoma cancer cells when being combined with cisplatin and can effectively slow down the side effects generated by cisplatin. The medicine for treating the gallbladdercancer has great application potential.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a Usnea longa derivative and its application, especially the application in preparing a medicine for treating gallbladder cancer. The Usnea longa derivative is extracted from a natural medicine Usnea longissima. Background technique [0002] Gallbladder cancer is a rare malignant tumor, which occupies the first place among gallbladder malignant tumors. Gallbladder cancer is the most common malignant tumor of the biliary system, of which adenocarcinoma is the main one, accounting for about 82%. The incidence of gallbladder cancer has risen rapidly in recent years, ranking fifth among digestive tract tumors. Gallbladder cancer is considered to be one of the most aggressive and lethal malignancies. The incidence of gallbladder cancer is relatively high in my country, and it has increasingly become a malignant disease that seriously threatens the lives of the broad mas...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C49/83C07C45/78A61K31/122A61K33/243A61K45/06A61P35/00
CPCA61K31/122A61K33/24A61K45/06A61P35/00C07C49/83A61K2300/00
Inventor 刘涛李燕军陈海云
Owner 山西白求恩医院
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