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Preparation method of andrographolide enteric dry suspension

A technology of andrographolide and dry suspension, applied in the field of medicine, can solve problems such as easy degradation of andrographolide, and achieve the effects of improving bioavailability, protecting quality and increasing compliance

Active Publication Date: 2020-06-19
HUANGSHAN C KING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the deficiencies in the prior art, the present invention provides a preparation method of andrographolide enteric-coated dry suspension, which solves the problem that existing andrographolide is easily degraded in gastric juice

Method used

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  • Preparation method of andrographolide enteric dry suspension
  • Preparation method of andrographolide enteric dry suspension
  • Preparation method of andrographolide enteric dry suspension

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preparation example Construction

[0041] The invention discloses a preparation method of andrographolide enteric-coated dry suspension, comprising the following steps:

[0042] (1) Preparation of particulate matter

[0043] Dissolve hydroxypropyl cellulose with 20% to 95% ethanol aqueous solution and add sodium lauryl sulfate to prepare a solvent with a solid content of 3% to 5% as a binder;

[0044] After sieving andrographolide, lactose and microcrystalline cellulose, add them to a high-speed centrifugal granulation coating machine, and carry out spray granulation with the binder. The mesh number of andrographolide, lactose and microcrystalline cellulose sieved In practice, conventional settings are required; dry the granules after they are formed; the spray rate of the high-speed centrifugal granulator coating machine is 2-15mL / min, the speed is 100-300r / min, and the rotation is 10-30min; the drying temperature is 40°C, and the drying time is 8-12 hours, the dried particles pass through a 60-100 mesh sieve...

Embodiment

[0067] The above method was used to prepare andrographolide enteric-coated dry suspension, and the specific composition ratios are shown in Table 1 and Table 2 below.

[0068] Table 1 Raw material ratio (parts by weight)

[0069]

[0070] Table 2 Raw material ratio (parts by weight)

[0071]

[0072]

[0073] Andrographolide enteric-coated dry suspension was prepared according to the ratios in Table 1 and Table 2, and the process parameters for preparing granules by a high-speed centrifugal granulator coating machine are shown in Table 3 below.

[0074] Table 3 Process parameters for the preparation of particulate matter

[0075] group Speed / r·min -1

Rotation time / min Spray rate / mL2min -1

Drying time / h 1 160 20 8 10

[0076] After the preparation of the granules is completed, the granules are coated with an isolation layer and an enteric layer, and the process parameters of the coating machine during the process of coating the i...

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Abstract

The invention relates to the technical field of medicines and specifically relates to a preparation method of an andrographolide enteric dry suspension. A specific technical solution is that the preparation method of the andrographolide enteric dry suspension specifically includes: dissolving hydroxypropyl cellulose, and then, adding sodium dodecyl sulfate to prepare a solvent containing 3%-5% ofsolids as a binder; next, sieving andrographolide, lactose and microcrystalline cellulose, then, adding the sieved andrographolide, lactose and microcrystalline cellulose into a high-speed centrifugalpelletizing and coating machine, forming particles, and then, drying the particles; and coating the dried particles with isolating layers and enteric layers in the coating machine, and finally, mixing the particles with a suspending agent and a corrigent to finally prepare the andrographolide enteric dry suspension. By using the preparation method, the problem that an existing andrographolide dispersible tablet is extremely easy to degrade in gastric juice is solved.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a preparation method of andrographolide enteric-coated dry suspension. Background technique [0002] Andrographolide, molecular formula C 20 h 30 o 5 , the main active ingredient of the natural plant Andrographis paniculata, has the effects of dispelling heat and detoxification, reducing inflammation and relieving pain, and has special curative effects on bacterial and viral upper respiratory tract infections and dysentery. It is known as a natural antibiotic drug. [0003] Andrographolide preparations for clinical application mainly include andrographolide tablets, andrographolide soft capsules, andrographolide dripping pills, and andrographolide dispersible tablets, all of which are gastric-soluble preparations. The test results of Andrographolide Tablets, Andrographolide Soft Capsules, Andrographolide Dropping Pills, and Andrographolide Dispersible Tablets under weak acid ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K47/38A61K47/32A61K31/365A61P31/04A61P31/12A61P11/00A61P1/12A61J3/00
CPCA61K9/5073A61K9/5089A61K9/5047A61K9/5026A61K31/365A61P31/04A61P31/12A61P11/00A61P1/12A61J3/005A61J2200/42
Inventor 司鹏付杰周世文
Owner HUANGSHAN C KING PHARMA
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