Surface enhanced Raman scattering optical flow chip and cleaning method thereof

Abstract

The invention discloses a surface enhanced Raman scattering optical flow chip and a cleaning method thereof. The optical flow chip includes a substrate, a microfluidic channel which is arranged in thesubstrate and is used for accommodating a to-be-detected solution, an optical fiber which comprises an optical signal input end used for accessing an optical signal and an excitation end arranged inthe microfluidic channel, and a metal nano island substrate which is formed on the end surface of the excitation end and is used for generating surface plasma resonance under the excitation of external laser so as to adsorb substance molecules in the to-be-detected solution. The cleaning method comprises the following steps: introducing deionized water into the microfluidic channel, and enabling the deionized water to submerge the metal nano island substrate; and accessing an optical signal into the optical signal input end, closing the optical signal after a preset duration, and removing thedeionized water in the microfluidic channel. The chip is simple in structure, small in size, easy and convenient to manufacture, can detect low-concentration substances to be detected, can be rapidlycleaned and has improved reusability.

Description

technical field [0001] The invention belongs to the technical field of optofluidic detection, and in particular relates to an optofluidic chip with surface-enhanced Raman scattering and a cleaning method thereof. Background technique [0002] Surface-Enhanced Raman Scattering (SERS), as a common and advanced material detection method, plays a vital role in the fields of chemistry, biomedicine and environmental protection. Since the SERS intensity is related to the surface plasmon resonance of the metal nanostructures, and strongly depends on the geometry of the metal nanostructures. Therefore, common SERS substrates are mainly prepared by chemical adsorption, laser-induced deposition, in-situ reduction, and photolithography to prepare metal nanoparticles / structures. Although these SERS substrates have become relatively mature and common tools for enhancing Raman signals, their high fabrication costs and complex processes require specialized equipment and specialized operati...

AI Technical Summary

Problems solved by technology

Although these SERS substrates have become relatively mature and are common tools for enhancing Raman signals, their high preparation costs and complicated processes require specialized equipment and specialized operations.

Moreover, the relatively large substrate area limits their miniaturization and integration, which greatly limits the further application of SERS detection in trace liquid detection and real-time detection.

Optical fiber sensing has the advantages of simple preparation, small size, and flexible operation, but it can only detect SERS signals in high-concentration solutions and is difficult to self-clean, which limits the sensitivity and repeatability of optical fiber substrates.

Images