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Pharmaceutical composition for treating traumatic brain injury and preparation thereof

A composition and traumatic technology, applied in the field of medicine, can solve problems such as the record of the treatment effect of traumatic brain injury TBI and the like

Active Publication Date: 2020-06-12
慈溪市人民医院医疗健康集团
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no record in the prior art about its therapeutic effect on traumatic brain injury TBI

Method used

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  • Pharmaceutical composition for treating traumatic brain injury and preparation thereof
  • Pharmaceutical composition for treating traumatic brain injury and preparation thereof
  • Pharmaceutical composition for treating traumatic brain injury and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0021] The following non-limiting examples are provided to further illustrate the invention.

[0022] Embodiment The effect of combined application of edaravone and isoxuling on TBI rats in vivo animal experiments

[0023] 1. Experimental materials and model preparation

[0024] 1. Materials

[0025] Adult male clean SD rats, weighing about 250g. TUNEL apoptosis detection kit; TNF-α, IL-6, IL-1α, IL-1β enzyme-linked immunosorbent assay (ELISA) kit; Edaravone (Edaravone injection: 5ml (10mg) / branch, Nanjing Simcere Dongyuan Pharmaceutical Co., Ltd.); Isoxalin (Isotalin hydrochloride, sigma company).

[0026] 2. Experimental animals and grouping

[0027] Healthy male SD rats, weighing about 250g, 50 were randomly divided into five groups, 10 in each group, grouped as follows:

[0028] The first group: sham operation group (Sham group)

[0029] The second group: TBI group (model control group)

[0030] The third group: Edaravone 3mg / kg

[0031] The fourth group: 1 mg / kg ...

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Abstract

The invention provides a pharmaceutical composition for treating traumatic brain injury and a preparation of the pharmaceutical composition. The pharmaceutical composition comprises edaravone, isoxsuprine and a pharmaceutically acceptable carrier. The pharmaceutical composition can improve the neurological function after cerebral trauma, reduce the encephaledema degree after cerebral trauma, inhibit nerve cell apoptosis and reduce microglial cell mediated central inflammatory response.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a medicine for treating brain injury, in particular to a pharmaceutical composition and preparation for treating traumatic brain injury. Background technique [0002] Traumatic brain injury (Traumatic brain injury, TBI), also known as intracranial injury, is a common disease in neurosurgery, and is recognized as one of the frequently-occurring and difficult-to-heal injuries. A large number of studies have confirmed that the brain dysfunction after TBI is not only caused by the primary injury such as the initial mechanical force, but also largely related to the complex neuron "second hit" after the injury, that is, the secondary The mechanism mainly includes calcium overload, excitatory amino acid toxicity, mitochondrial dysfunction, oxidative stress, apoptosis and inflammatory response. [0003] In the early stage after TBI, a large number of pro-inflammatory cytokines are release...

Claims

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Application Information

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IPC IPC(8): A61K31/4152A61K31/138A61P25/00A61P7/10
CPCA61K31/138A61K31/4152A61P7/10A61P25/00A61K2300/00
Inventor 魏晓捷许信龙陈再丰邬芬赞张宏宇
Owner 慈溪市人民医院医疗健康集团
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